| Project/Area Number |
20590143
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Mie University |
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Principal Investigator |
OKUDA Masahiro Mie University, 医学部附属病院, 教授 (70252426)
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| Co-Investigator(Kenkyū-buntansha) |
IWAMOTO Takuya 三重大学, 医学附属病院, 准教授 (30447867)
HIRAKU Yusuke 三重大学, 大学院・医学系研究科, 講師 (30324510)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | LLC-PK_1 / テトラエチルアンモニウム / 高グルコース / Trolox / 2011 / 10 / 02 / 虚血再灌流障害 / シメチジン / 腎分泌クリアランス / 肝虚血再灌流 / 酸化ストレス / rOCT2 / rMATE1 / 腎クリアランス / シクロスポリン / CYP3A / P-糖タンパク質 / OCT2 / LLC-PK1 / tetraethylammonium / L-buthionine sulfoximine / 多孔性フィルター / 脂質過酸化 |
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| Research Abstract |
Effect of oxidative stress on the expression and function of organiccation transporter swere studied using cultured renal epithelial cell 1ine, LLC-PK_1, which retains organic cation transporters, and rats subjected to liver ischemia-reperfusion. Influx of cationic drugs across basolateral membranes into renal epithelial cells were decreased by oxidative stress by direct or indirect effect, and the involvement of decreased expression of organic cation transporter, OCT2, was suggested. These results provideuseful information for analysisof renal clearance of cationicdrugs in occasions of organdysfunction accompanying oxidative stress.
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