Appropriate use of the oral fluoropyrimidine anticancer drugs in patients with colorectal cancer
| Project/Area Number |
20590144
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Medical pharmacy
|
|---|
| Research Institution | Kyoto Pharmaceutical University |
|---|
Principal Investigator |
NISHIGUCHI Kohshi Kyoto Pharmaceutical University, 薬学部, 教授 (80379437)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SAKAEDA Toshiyuki 京都大学, 薬学部, 教授 (00304098)
HIRAI Midori 神戸大学, 医学部附属病院, 教授 (70228766)
MINAMI Hironobu 神戸大学, 医学部附属病院, 教授 (60450574)
TAMURA Takao 近畿大学, 医学部附属病院, 准教授 (80324929)
YAMAMORI Motohiro 武庫川女子大学, 薬学部, 講師 (10444613)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 大腸癌 / がん化学療法 / フッ化ピリミジン系 / 代謝拮抗剤 / 適正使用 |
|---|
| Research Abstract |
In the patients with advanced colorectal cancer, pharmacokinetic evaluation was performed to assess whether constant exposure to 5-FU in FOLFIRI regimen was achieved by repetitive oral UFT, and clinical outcome was evaluated. In this study, the incidence of dose-limiting toxicity was almost the same as for FOLFIRI regimen. Pharmacokinetic evaluation suggested continuous exposure to 5-FU by means of repetitive oral UFT administration. However, the bolus injection of 5-FU was thought to be necessary to ensure the efficacy in the chemotherapeutic regimen with repetitive oral UFT.
|
Report
(4 results)
Research Products
(17 results)
-
[Journal Article] Effect of dose-escalation of 5-fluorouracil on circadian variability of its pharmacokinetics in Japanese patients with Stage III/IVa esophageal squamous cell carcinoma.2010
Author(s)
Akiko Kuwahara, Motohiro Yamamori, Kohshi Nishiguchi, Tatsuya Okuno, Naoko Chayahara, Ikuya Miki, Takao Tamura, Kaori Kadoyama, Tsubasa Inokuma, Yoshiji Takemoto, Tsutomu Nakamura, Kazusaburo Kataoka, Toshiyuki Sakaeda
-
Journal Title
Int.J.Med.Sci. 7
Pages: 48-54
Related Report
Peer Reviewed
-
-
-
[Journal Article] Replacement of cisplatin with nedaplatin in a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma.2009
Author(s)
Akiko Kuwahara, Motohiro Yamamori, Kohshi Nishiguchi, Tatsuya Okuno, Naoko Chayahara, Ikuya Miki, Takao Tamura, Tsubasa Inokuma, Yoshiji Takemoto, Tsutomu Nakamura, Kazusaburo Kataoka, Toshiyuki Sakaeda
-
Journal Title
Int.J.Med.Sci. 6
Pages: 305-311
NAID
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Three-dimensional, but not two-dimensional, culture results in tumor growth enhancement after exposure to anticancer drugs.2008
Author(s)
Chiho Komoto, Tsutomu Nakamura, Nobuko Ohmoto, Hironao Kobayashi, Tatsurou Yagami, Kohshi Nishiguchi, Koichi Iwaki, Akiko Kuwahara, Motohiro Yamamori, Noboru Okamura, Katsuhiko Okumura, Toshiyuki Sakaeda
-
Journal Title
Kobe J.Med.Sci. 53
Pages: 335-343
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
