| Project/Area Number |
20590144
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Medical pharmacy
|
|---|
| Research Institution | Kyoto Pharmaceutical University |
|---|
Principal Investigator |
NISHIGUCHI Kohshi Kyoto Pharmaceutical University, 薬学部, 教授 (80379437)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SAKAEDA Toshiyuki 京都大学, 薬学部, 教授 (00304098)
HIRAI Midori 神戸大学, 医学部附属病院, 教授 (70228766)
MINAMI Hironobu 神戸大学, 医学部附属病院, 教授 (60450574)
TAMURA Takao 近畿大学, 医学部附属病院, 准教授 (80324929)
YAMAMORI Motohiro 武庫川女子大学, 薬学部, 講師 (10444613)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 大腸癌 / がん化学療法 / フッ化ピリミジン系 / 代謝拮抗剤 / 適正使用 |
|---|
| Research Abstract |
In the patients with advanced colorectal cancer, pharmacokinetic evaluation was performed to assess whether constant exposure to 5-FU in FOLFIRI regimen was achieved by repetitive oral UFT, and clinical outcome was evaluated. In this study, the incidence of dose-limiting toxicity was almost the same as for FOLFIRI regimen. Pharmacokinetic evaluation suggested continuous exposure to 5-FU by means of repetitive oral UFT administration. However, the bolus injection of 5-FU was thought to be necessary to ensure the efficacy in the chemotherapeutic regimen with repetitive oral UFT.
|
