Analysis for molecular mechanism of contactin associated protein on intractable epilepsy

• Project/Area Number: 20590149
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Kagoshima University
• Principal Investigator: TAKEDA Yasuo Kagoshima University, 医学部・歯学部附属病院, 准教授 (60245462)
• Co-Investigator(Kenkyū-buntansha): YAMADA Katushi 鹿児島大学, 医学部・歯学部附属病院, 教授 (00037491)
• Research Collaborator: XIAO Zhi-cheng Monash大学, 医学部, 教授,オーストラリア ; FUTAGAWA Toshitaka 鹿児島大学, 医学部・歯学部附属病院, 薬剤師 ; OISO Shigeru 鹿児島大学, 医学部・歯学部附属病院, 薬剤師 ; MASUDA Shogo 鹿児島大学, 医学部・歯学部附属病院, 薬剤師
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 臨床薬学 / 難治性てんかん / コンタクチン関連蛋白質 / トランスゴルジ輸送系 / 神経接着分子 / カリウムチャネル / 跳躍伝導 / トランスゴルジ輸送 / てんかん / Caspr2 / 跳耀伝導 / トランスゴルジネットワーク / コンタクチン / Carboxypeptidase E / PDZドメイン

Research Abstract

To investigate the molecular mechanism for trafficking of Contactin-associated protein (Caspr) 2 to the cem membrane, we identified carboxypeptidase E (CPE) as a binding partner of Caspr2. Both Caspr2- and CPE-like immunoreactivities (IR) were found to co-localize in the apical dendrites and cell bodies of rat cortical neurons. In subcellular localization analysis, Caspr2- and CPE-like IRs were comigrated in the fractions of Golgi/ER. When Caspr2 cDNA was transfected into COS-7 cells with or without CPE cDNA, Caspr2 localized only in Golgi/ER without CPE, but localized in both Golgi/ER and plasma membrane with CPE. Our data suggest that CPE may be a key molecule to regulate Caspr2 trafficking to the cell membrane.

Research Products

• [Journal Article] Higher linezolid exposure and higher frequency of thrombocytopenia in patients with renal dysfunction. (2010)
  • Author(s): Matsumoto K., Takeshita, A., Ikawa, K., Shigemi, A., Yaji, K., Shimodozono Y., Morikawa N., Takeda Y., Yamada K.
  • Journal Title: Int.J.Antimicrob.Agents 36 Pages: 179-181
  • Peer Reviewed
• [Journal Article] Synaptic formation in subsets of glutamatergic terminals in the mouse hippocampal formation is affected by a deficiency in the neural cell recognition molecule NB-3. (2010)
  • Author(s): Sakurai, K., Toyoshima, M., Takeda Y., Shimoda, Y., Watanabe K.
  • Journal Title: Neurosci.Lett. 473 Pages: 102-106
  • Peer Reviewed
• [Journal Article] Major vault protein forms complexes with hypoxia-inducible factor (HIF)-1α and reduces HIF-1α level in ACHN human renal adenocarcinoma cells. (2010)
  • Author(s): Iwashita, K., Ikeda, R., Takeda Y., Sumizawa, T., Furukawa, T., Yamaguchi, T., Akiyama, S., Yamada K.
  • Journal Title: Cancer Sci. 101 Pages: 920-926
  • NAID: 10026590870
  • Peer Reviewed
• [Journal Article] Determination of teicoplanin through concentration target and appropriate total dose during the first 3 days : a retrospective study in patients with MRSA infections. (2010)
  • Author(s): Matsumoto K., Kanazawa, N., Ikawa, K., Fukamizu T., Shigemi, A., Yaji, K., Shimodozono Y., Morikawa N., Takeda Y., Yamada K.
  • Journal Title: J.Infect.Chemother. 16 Pages: 193-199
  • Peer Reviewed
• [Journal Article] Safety evaluation of Black Rice Vinegar (Kurosu) from a Jar on food-drug interaction : 30-day ingestion study on expressions of drug metabolism enzyme and transporters in rats. (2010)
  • Author(s): Shibayama, Y., Nagano, M., Fujii, A., Takeda Y., Yamada K.
  • Journal Title: J.Health Sci. 56 Pages: 712-716
  • NAID: 130000425110
  • Peer Reviewed
• [Journal Article] Adverse events of superselective intra-arterial infusion chemotherapy in patients with oral cancer. (2010)
  • Author(s): Ushiyama, M., Ikeda, R., Yamaguchi H., Miyawaki, A., Nitta, T., Yamaguchi T., Tajitsu, Y., Nishizawa, Y., Shimodozono, Y, Hijioka, H., Furukawa, T., Akiyama, S., Nakamura, N., Takeda, Y., Yamada, K.
  • Journal Title: Journal of Applied Therapeutic Research Volume: 7 Pages: 58-64
  • Peer Reviewed
• [Journal Article] Major vault protein forms complexes with hypoxia-inducible factor (HIF)-1α and reduces HIF-1α level in ACHN human renal adenocarcinoma cells. (2010)
  • Author(s): Iwashita, K., Ikeda, R., Takeda, Y., Sumizawa, T., Furukawa, T., Yamaguchi, T., Akiyama, S., Yamada, K.
  • Journal Title: Cancer Sciences Volume: 101 Pages: 920-926
  • NAID: 10026590870
  • Peer Reviewed
• [Journal Article] The role of thymidine phosphorylase in the induction of early growth response protein-1 and thrombospondine-1 by 5-fluorouracil in human cancer carcinoma cells. (2010)
  • Author(s): Matsushita, S., Ikeda, R., Nishizawa, Y., Che, X-F., Furukawa, T., Miyadera, K., Ushiyama, M., Tajitsu, Y., Yamamoto, M., Takeda, Y., Minami, K., Mataki, H., Kanzaki, T., Yamada, K., Kanekura, T., Akiyama, S.
  • Journal Title: International Journal of Oncology Volume: 36 Pages: 1193-1200
  • Peer Reviewed
• [Journal Article] Determination of teicoplanin through concentration target and appropriate total dose during the first 3 days : a retrospective study in patients with MRSA infections. (2010)
  • Author(s): Matsumoto, K., Kanazawa, N., Ikawa, K., Fukamizu, T., Shigemi, A., Yaji, K., Shimodozono, Y., Morikawa, N.Takeda, Y., Yamada, K.
  • Journal Title: Journal of Infection Chemotherapy Volume: 16 Pages: 193-199
  • Peer Reviewed
• [Journal Article] Synaptic formation in subsets of glutamatergic terminals in the mouse hippocampal formation is affected by a deficiency in the neural cell recognition molecule NB-3. (2010)
  • Author(s): Sakurai, K., Toyoshima, M., Takeda, Y., Shimoda, Y., Watanabe K.
  • Journal Title: Neuroscience Letter Volume: 473 Pages: 102-106
  • Peer Reviewed
• [Journal Article] Higher linezolid exposure and higher frequency of thrombocytopenia in patients with renal dysfunction. (2010)
  • Author(s): Matsumoto, K., Takeshita, A., Ikawa, K., Shigemi, A., Yaji, K., Shimodozono, Y., Morikawa, N., Takeda, Y., Yamada, K.
  • Journal Title: International Journal of Antimicrobial Agents Volume: 36 Pages: 179-181
  • Peer Reviewed
• [Journal Article] Safety evaluation of Black Rice Vinegar (Kurosu) from a Jar on food-drug interaction : 30-day ingestion study on expressions of drug metabolism enzyme and transporters in rats. (2010)
  • Author(s): Shibayama, Y., Nagano, M., Fujii, A., Takeda, Y., Yamada, K.
  • Journal Title: Journal of Health Sciences Volume: 56 Pages: 712-716
  • NAID: 130000425110
  • Peer Reviewed
• [Journal Article] An initial dosing method for teicoplanin based on the area under the serum concentration time curve requires for MRSA eradication. (2010)
  • Author(s): Kanazawa, N., Matsumoto, K., Ikawa, K., Fukamizu, T., Shigemi, A., Yaji, K., Shimodozono, Y., Morikawa, N., Takeda, Y., Yamada, K.
  • Journal Title: Journal of Infection Chemotherapy Volume: 17 Pages: 297-300
  • NAID: 10028171743
  • Peer Reviewed
• [Journal Article] Multidrug resistance protein 2 implicates anticancer drug-resistance to sorafenib. (2010)
  • Author(s): Shibayama, Y, Nakano, K., Maeda, H., Taguchi, M., Ikeda, R., Sugawara, M., Iseki, K., Takeda, Y., Yamada, K.
  • Journal Title: Biological Pharmacological Bulletin Volume: 34 Pages: 433-435
  • NAID: 130000657826
  • Peer Reviewed
• [Journal Article] 腎機能障害を有する術後MRSA感染症患者2例におけるリネゾリドの体内動態 (2010)
  • Author(s): 竹下鮎美、松元一明、茂見茜里、猪川和朗、森川則文、武田泰生、山田勝士
  • Journal Title: 日本外科感染症学会雑誌 Volume: 7 Pages: 373-376
  • Peer Reviewed
• [Journal Article] Major vault protein forms complexes with hypoxia-inducible factor(HIF)-1α and reduces HIF-1α level in ACHN human renal adenocarcinoma cells (2010)
  • Author(s): Iwashita, K., Ikeda, R., Takeda, Y., Sumizawa, T., Furukawa, T., Yamaguchi, T., Akiyama, S., Yamada, K.
  • Journal Title: Cancer Sciences January(In press)
  • NAID: 10026590870
  • Peer Reviewed
• [Journal Article] Determination of teicoplanin through concentration target and appropriate total dose during the first 3 days : a retrospective study in patients with MRSA infections (2010)
  • Author(s): Matsumoto, K., Kanazawa, N., Ikawa, K., Fukamizu, T., Shigemi, A., Yaji, K., Shimodozono, Y., Morikawa, N., Takeda, Y., Yamada, K.
  • Journal Title: Journal of Infection Chemotherapy March(In press)
  • Peer Reviewed
• [Journal Article] Contactin-associated protein (Caspr) 2 interacts with carboxypeptidase E in the central nervous system. (2009)
  • Author(s): Oiso, S., Takeda Y, Futagawa, T., Miura, T., Kuchiiwa, S., Nishida, K., Ikeda, R., Kariyazono, H., Watanabe, K., Yamada K.
  • Journal Title: J.Noeurochem. 109 Pages: 158-167
  • Peer Reviewed
• [Journal Article] Deficiency of Neural recognition molecule NB-2 affects the development of glutamatergic auditory pathways from the ventral cochlear nucleus to superior olivary complex in mouse. (2009)
  • Author(s): Toyoshima, M., Sakurai, K., Shimazaki, K., Takeda Y., Shimoda, Y., Watanabe, K.
  • Journal Title: Developmental Biol. 336 Pages: 192-220
  • Peer Reviewed
• [Journal Article] Contribution of the neural cell recognition molecule NB-3 to synapse formation between parallel fibers and Purkinje cells in mouse. (2009)
  • Author(s): Sakurai, K., Ueda, H., Matsubara, K., Takeda Y., Karagogeos, D., Shimoda, Y., Watanabe, K.
  • Journal Title: Developmental Neurobiol. 69 Pages: 811-824
  • Peer Reviewed
• [Journal Article] Correlation between voriconazole trough plasma concentration and hepatotoxicity in patients with different CYP2C19 genotypes. (2009)
  • Author(s): Matsumoto K., Ikawa, K., Abematsu, K., Fukunaga N., Nishida, K., Fukamizu T., Shimodozono Y., Morikawa N., Takeda Y., Yamada K.
  • Journal Title: Int.J.Antimicrob.Angents, 34 Pages: 91-94
  • Peer Reviewed
• [Journal Article] Preferential localization of neural cell recognition molecule NB-2 in developing glutamatergic neurons in the rat auditory brainstem. (2009)
  • Author(s): Toyoshima, M., Sakurai, K., Shimazaki, K., Takeda Y, Nakamoto, M., Serizawa, S., Shimoda, Y., Watanabe, K.
  • Journal Title: J.Comp.Neurol. 531 Pages: 349-362
  • Peer Reviewed
• [Journal Article] Effect of methotrexate treatment on expression levels of organic anion transporter polypeptide 2, P-glycoprotein and bile salt export pump in rats. (2009)
  • Author(s): Shibayama, Y., Takeda Y., Yamada K.
  • Journal Title: Biol.Pharm.Bull. 32 Pages: 493-496
  • NAID: 110007122693
  • Peer Reviewed
• [Journal Article] シクロスポリンおよびタクロリムスのTDM研究支援ソフトウェアの開発 (2009)
  • Author(s): 金子生、猪川和朗、福原慶、森川則文、福永直子、深水知英、松元一明、下堂薗権洋、武田泰生、山田勝士
  • Journal Title: TDM研究 26巻 Pages: 52-58
  • Peer Reviewed
• [Journal Article] Preferential localization of neural cell recognition molecule NB-2 in developing glutamatergic neurons in the rat auditory brainstem (2009)
  • Author(s): Toyoshima, M., Sakurai, K., Shimazaki, K., Takeda, Y., Nakamoto, M., Serizawa, S., Shimoda, Y., Watanabe, K.
  • Journal Title: Journal of Comparative Neurology 531 Pages: 349-362
  • Peer Reviewed
• [Journal Article] Contactin-associated Protein(Caspr)2 interacts with carboxypeptidase E in the central nervous system (2009)
  • Author(s): Oiso, S., Takeda, Y., Futagawa, T., Miura, T., Kuchiiwa, S., Nishida, K., Ikeda, R, Kariyazono, H., Watanabe, K, Yamada, K.
  • Journal Title: Journal of Neurochemistry 109 Pages: 158-167
  • Peer Reviewed
• [Journal Article] Correlation between voriconazole trough plasma concentration and hepatotoxicity in patients with different CYP2C19 genotypes (2009)
  • Author(s): Matsumoto, K., Ikawa, K., Abematsu, K., Fukunaga, N., Nishida, K., Fukamizu, T., Shimodozono, Y., Morikawa, N., Takeda, Y., Yamada, K.
  • Journal Title: International Journal of Antimicrobial Agents 34 Pages: 91-94
  • Peer Reviewed
• [Journal Article] Contribution of the neural cell recognition molecule NB-3 to synapse formation between parallel fibers and Purkinje cells in mouse. Developmental Neurobiol., Aug, 69(12) : 811-824 (2009)
  • Author(s): Sakurai, K., Ueda, H., Matsubara, K., Takeda, Y., Karagogeos, D., Shimoda, Y., Watanabe, K.
  • Journal Title: Developmental Neurobiology 69 Pages: 811-824
  • Peer Reviewed
• [Journal Article] Correlation between meropenem and doripenem use density and the incidence of carbapenem-resistant Pseudomonas aeruginosa (2009)
  • Author(s): Shigemi, A., Matsumoto, K., Yaji, K., Shimodozono, Y., Takeda, Y., Miyanohara, H., Kawamura, H., Orita, M., Nishi, J., Yamada, K.
  • Journal Title: International Journal of Antimicrobial Agents 34 Pages: 589-591
  • Peer Reviewed
• [Journal Article] Deficiency of Neural recognition molecule NB-2 affects the development of glutamatergic auditory pathways from the ventral cochlear nucleus to superior olivary complex in mouse (2009)
  • Author(s): Toyoshima, M., Sakurai, K., Shimazaki, K., Takeda, Y., Shimoda, Y., Watanabe, K.
  • Journal Title: Developmental Biology 336 Pages: 192-220
  • Peer Reviewed
• [Journal Article] A TAG1-APP signaling pathway through Fe65 negatively modulates neurogenesis. (2008)
  • Author(s): Ma, Q.-H., Futagawa, T., Yang, W.-L., Jiang, X.-D., Zeng L., Takeda Y., Xu, R.-X., Bagnard, D., Schachner, M., Furley, A.J., Karagogeos, D., Watanabe, K., Dawe, G.S., Xiao, Z.-C.
  • Journal Title: Nature Cell Biol. 10 Pages: 283-294
  • Peer Reviewed
• [Journal Article] Neural recognition molecules CHL1 and NB-3 regulate apical dendrite orientation in the neocortex via PTPα. (2008)
  • Author(s): Ye, H., Tan, Y. L.J., Ponniah, S., Takeda Y., Wang, S.-Q., Schachner, M., Watanabe, K., Pallen, C.J., Xiao, Z.-C.
  • Journal Title: EMBO J. 27 Pages: 188-200
  • Peer Reviewed
• [Journal Article] Up-regulation of matrix metalloproteinase-3 in the dorsal root ganglion of rats with paclitaxel-induced neuropathy. (2008)
  • Author(s): Nishida, K., Kuchiiwa, S., Oiso, S., Futagawa, T., Masuda, S., Takeda Y., Yamada K.
  • Journal Title: Cancer Sci. 99 Pages: 1618-1625
  • NAID: 10024009944
  • Peer Reviewed
• [Journal Article] Stability of high-dose methylcobalamin injection. (2008)
  • Author(s): Kusadome, C., Shibayama, Y., Nishi, Y., Takeda Y., Yamada K.
  • Journal Title: J.Applied Ther.Res. 6 Pages: 15-18
  • Peer Reviewed
• [Journal Article] Thymidine phosphorylase inhibits the expression of proapoptotic protein BNIP3. (2008)
  • Author(s): Ikeda, R., Tajitsu, Y., Iwashita, K., Che, X.F., Yoshida, K., Ushiyama, M., Furukawa, T., Komatsu, M., Yamaguchi, T., Shibayama, Y., Yamamoto, M., Zhao, H.Y., Arima, J., Takeda Y., Akiyama, S., Yamada K.
  • Journal Title: Biochem.Biophys.Res.Commun. 370 Pages: 220-224
  • Peer Reviewed
• [Journal Article] Neural recognition molecule CHLl and NB-3 regulate apical dendrite orientation in the neocortex via PTPα (2008)
  • Author(s): Ye, H., Takeda, Y., Xiao, Z. -C., et al.
  • Journal Title: EMBO Journal 27 Pages: 188-200
  • Peer Reviewed
• [Journal Article] A TAG1-APP signaling pathway through Fe65 negatively modulates neurogenesis. (2008)
  • Author(s): Ma, QH., Futagawa, T., Takeda, Y., et al.
  • Journal Title: Nature Cell Biology 10 Pages: 283-294
  • Peer Reviewed
• [Journal Article] Up-regulation of matrix metalloproteinase-3 in the dorsal root ganglion of rats with paclitaxel-induced neuropathy (2008)
  • Author(s): Nishida, K., Takeda, Y., Yamada, K., et al.
  • Journal Title: Cancer Science 99 Pages: 1618-1625
  • NAID: 10024009944
  • Peer Reviewed
• [Journal Article] Stability of high-dose methylcobalamin injection (2008)
  • Author(s): Kusadome, C., Takeda, Y., Yamada, K., et al.
  • Journal Title: Journal of Applied Therapeutic Research 6 Pages: 15-18
  • Peer Reviewed
• [Journal Article] Relationship between methotrexate concentration in serum and half-life of methotrexate in high-dose methotrexate therapy : a retrospective study (2008)
  • Author(s): Shibayama, Y., Takeda, Y., Yamada, K., et al.
  • Journal Title: Journal of Applied Therapeutic Research 6 Pages: 25-28
  • Peer Reviewed
• [Journal Article] Thymidine phosphorylase inhibits the expression of proapoptotic protein BNIP3 (2008)
  • Author(s): Ikeda, R., Takeda, Y., Yamada, K., et al.
  • Journal Title: Biochemical and Biophysical Research Communications 370 Pages: 220-224
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• [Journal Article] Subcellular Distribution and Potential Detoxication Mechanisms of Mercury in the Liver of the Javan Mongoose (Herpestes Javanicus)in Amamioshima Island, Japan (2008)
  • Author(s): Horai, S., Takeda, Y., Yamada, K., et al.
  • Journal Title: Environmental Toxicology and Chemistry 6 Pages: 1354-1360
  • Peer Reviewed
• [Journal Article] Hyperosmotic stress up-regulates the expression of major vault protein in SW620 human colon cancer cells (2008)
  • Author(s): Ikeda, R., Takeda, Y., Yamada, K., et al.
  • Journal Title: Experimental Cell Research 314 Pages: 3017-3020
  • Peer Reviewed
• [Journal Article] Renal function as a predictor linezorid-induced thrombocytopenla (2008)
  • Author(s): Matsumoto, K., Takeda, Y. Yamada, K., et al.
  • Journal Title: International Journal of Antimicrobial Agents 33 Pages: 98-99
  • Peer Reviewed
• [Journal Article] Effect of methotrexate treatment on expression levels of organic anion transporter polypeptide 2, P-glycoprotein and bile salt export pump in rats (2008)
  • Author(s): Shibayama, Y., Takeda, Y., Yamada, K.
  • Journal Title: Biological & Pharmaceutical Bulletin 32 Pages: 493-496
  • NAID: 110007122693
  • Peer Reviewed
• [Presentation] (2010)
  • Author(s): 山口沙織、益田将吾、二川俊隆、鬼丸貴裕、末廣淑子、武田泰生、山田勝士
  • Organizer: 第27回日本薬学会九州支部大会
  • Place of Presentation: 長崎
  • Year and Date: 2010-12-11
• [Presentation] (2010)
  • Author(s): Futagawa T., Onimaru T., Chen, Z. C., Masuda S., Suehiro Y., Yamaguchi S., Xiao, Z. C., Takeda Y., Yamada K.
  • Organizer: The 20^<th> Japan-Korea Joint Seminar on Pharmacology
  • Place of Presentation: Kagoshima
  • Year and Date: 2010-11-26
• [Presentation] (2010)
  • Author(s): 末廣淑子、二川俊隆、益田将吾、鬼丸貴裕、山口沙織、武田泰生、山田勝士
  • Organizer: 第63回日本薬理学会西南部会
  • Place of Presentation: 鹿児島
  • Year and Date: 2010-11-26
• [Presentation] The interaction of contactin associated protein (Caspr) 4 with ligand of Numb protein X (LNX) 2 promotes neurogenesis in the developmental brain. (2010)
  • Author(s): Futagawa, T., Onimaru, T., Chen, Z.C., Masuda, S., Suehiro, Y., Yamaguchi, S., Xiao, Z.C., Takeda, Y., Yamada, K.
  • Organizer: The 20^<th> Japan-Korea Joint Seminar on Pharmacology
  • Place of Presentation: 鹿児島
  • Year and Date: 2010-11-26
• [Presentation] Isolation and characterization of gemcitabine-resistant in human non-small cell lung cancer A549 cells. (2010)
  • Author(s): Ikeda, R., Vermeulen, L.C., Kolesar, J.M., Takeda, Y., Yamada, K.
  • Organizer: The 20^<th> Japan-Korea Joint Seminar on Pharmacology
  • Place of Presentation: 鹿児島
  • Year and Date: 2010-11-26
• [Presentation] (2010)
  • Author(s): 武田泰生
  • Organizer: 第20 回日本医療薬学会
  • Place of Presentation: 千葉
  • Year and Date: 2010-11-13
• [Presentation] Molecular mechanism for neuropathic pain induced by anti-cancer drug paclitaxel. (2010)
  • Author(s): Takeda, Y.
  • Organizer: 第20回日本医薬学会年会
  • Place of Presentation: 千葉
  • Year and Date: 2010-11-13
• [Presentation] がん化学療法レジメンオーダリングシステム導入の問題点 (2010)
  • Author(s): 有馬純子、有馬由佳、下堂薗権洋、武田泰生、山田勝士
  • Organizer: 第20回日本医療薬学会年会
  • Place of Presentation: 千葉
  • Year and Date: 2010-11-13
• [Presentation] Analysis for the effect of pharmaceutical education about diabetes mellitus by pharmacists to medical staff. (2010)
  • Author(s): Kondo, T., Matsumoto, K., Yamaguchi, T., Ushinohama, K., Takeda, Y., Yamada, K.
  • Organizer: 第20回日本医療薬学会年会
  • Place of Presentation: 千葉
  • Year and Date: 2010-11-13
• [Presentation] Pharmacokinetic analysis for linezolid-induced thrombocytopenia. (2010)
  • Author(s): Takeda, Y., Matsumoto, K., Takeshita, A., Ikawa, K., Morikawa, N., Yamada, K.
  • Organizer: 日本薬物動態学会 第25回年回
  • Place of Presentation: 埼玉
  • Year and Date: 2010-11-08
• [Presentation] (2010)
  • Author(s): Saito, S., Arima, J., Shimodozono Y., Takeda Y., Yamada K.
  • Organizer: The 23^<rd> Federation of Asian Pharmaceutical Associations Congress
  • Place of Presentation: Taiwan
  • Year and Date: 2010-11-06
• [Presentation] Evaluation of antiemetics prescribed during cisplatin-based highly emetogenic chemotherapy in patients with advanced urothelial cancer. (2010)
  • Author(s): Fujisaki, Y., Sugawara, H., Shimodozono, Y., Yamaguchi, T., Takeda, Y., Yamada, K.
  • Organizer: The 23^<rd> Federation of Asian Pharmaceutical Associations Congress
  • Place of Presentation: 台北、台湾
  • Year and Date: 2010-11-05
• [Presentation] Role of the pharmacist in the operating room. (2010)
  • Author(s): Saito, S., Arima, J., Shimodozono, Y., Takeda, Y., Yamada, K.
  • Organizer: The 23^<rd> Federation of Asian Pharmaceutical Associations Congress
  • Place of Presentation: 台北、台湾
  • Year and Date: 2010-11-05
• [Presentation] Further attempts at preventing dispensing errors. (2010)
  • Author(s): Takeda, E., Shigenaga, A., Ushiyama, M., Yaji, K., Shimodozono, Y., Takeda, Y., Yamada, K.
  • Organizer: The 23^<rd> Federation of Asian Pharmaceutical Associations Congress
  • Place of Presentation: 台北、台湾
  • Year and Date: 2010-11-05
• [Presentation] (2010)
  • Author(s): Takeda Y., Matsumoto, K., Takeshita, A., Ikawa, K., Morikawa, N., Yamada K.
  • Organizer: 日本薬物動態学会第25回年会
  • Place of Presentation: 東京
  • Year and Date: 2010-10-08
• [Presentation] (2010)
  • Author(s): Ushiyama, M., Ikeda R., Miyawaki, A., Yamaguchi, T., Tazitsu Y., Nishizawa, Y., Mataki, H., Nakamura, N., Takeda Y., Yamada K.
  • Organizer: 70^<th> International Congress of FIP
  • Place of Presentation: Lisbon, Portugal
  • Year and Date: 2010-08-30
• [Presentation] Clinical evaluation and comparison of the two in vitro chemosensitivity test for patients with oral cancer. (2010)
  • Author(s): Ushiyama, M., Ikeda, R., Miyawaki, A., Yamaguchi, T., Tazitsu, Y., Nishizawa, Y., Mataki, H., Nakamura, N., Takeda, Y., Yamada, K.
  • Organizer: 70^<th> International Congress of FIP
  • Place of Presentation: リスボン、ポルトガル
  • Year and Date: 2010-08-30
• [Presentation] リネゾリドによって血小板減少が惹起される要因分析 (2010)
  • Author(s): 松元一明、竹下鮎美、猪川和朗、茂見茜里、屋地慶子、下堂薗権洋、森川則文、武田泰生、山田勝士
  • Organizer: 第27回日本TDM学会
  • Place of Presentation: 北海道
  • Year and Date: 2010-06-26
• [Presentation] 抗がん薬耐性細胞におけるマイクロRNAの発現変動 (2010)
  • Author(s): 柴山良彦、田口深雪、池田龍二、古川龍彦、武田泰生、山田勝士
  • Organizer: 第37回日本トキシコロジー学会年会
  • Place of Presentation: 沖縄
  • Year and Date: 2010-06-16
• [Presentation] ヒトグリオーマにおけるWntシグナルの作用解析(細胞運動を中心とする) (2010)
  • Author(s): 神野真幸、岐部俊郎、中村葉子、生駒今日子, 武田泰生、山田勝士、岸田想子、飯島幹雄、平野宏文、岸田昭世
  • Organizer: 日本生化学会九州支部例会
  • Place of Presentation: 鹿児島
  • Year and Date: 2010-05-22
• [Presentation] 癌浸潤・転移におけるコンタクチンの役割 (2010)
  • Author(s): 益田将吾, 二川俊隆, 西田健太朗, 田畑祥, 藤井寛樹, 武田泰生, 山田勝士
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪国際会議場
• [Presentation] (2009)
  • Author(s): 藤井寛樹、二川俊隆、益田将吾、石原義久、鬼丸貴裕、末廣淑子、山口沙織、武田泰生、山田勝士
  • Organizer: 第26回日本薬学会九州支部大会
  • Place of Presentation: 福岡
  • Year and Date: 2009-12-13
• [Presentation] 神経接着関連分子 Contactin associated protein(Caspr)4の機能解析 (2009)
  • Author(s): 二川俊隆, 益田将吾, 藤井寛樹, 鬼丸貴裕, 末廣淑子, 山口沙織, Zhong-can Chen, 武田泰生, 山田勝士
  • Organizer: 第62回日本薬理学会西南部会
  • Place of Presentation: リジェール松山
  • Year and Date: 2009-11-27
• [Presentation] 神経接着分子コンタクチンを介した癌浸潤・転移のメカニズム (2009)
  • Author(s): 益田将吾, 二川俊隆, 西田健太朗, 田畑祥, 藤井寛樹, 武田泰生, 山田勝士
  • Organizer: 第62回日本薬理学会西南部会
  • Place of Presentation: リジェール松山
  • Year and Date: 2009-11-27
• [Presentation] (2009)
  • Author(s): 武田泰生
  • Organizer: 2009 China-Japan Pharmacists' International Forum
  • Place of Presentation: Beijing, China
  • Year and Date: 2009-11-14
• [Presentation] (2009)
  • Author(s): 武田泰生, 西田健太朗, 山田勝士
  • Organizer: Asian Federation for Pharmaceutical Sciences
  • Place of Presentation: Fukuoka
  • Year and Date: 2009-10-16
• [Presentation] (2009)
  • Author(s): Kondo, T., Matsumoto, K., Tanaka, S., Yamaguchi, T., Nishi, S., Ueno K., Ogura, T., Takeda Y., Yamada K.
  • Organizer: 69^<th> International Congress of FIP
  • Place of Presentation: Istanbul, Turkey
  • Year and Date: 2009-09-05
• [Presentation] (2009)
  • Author(s): 武田泰生、益田将吾、二川俊隆、西田健太朗、田畑祥、藤井寛樹、山田勝士
  • Organizer: 医療薬学フォーラム2009
  • Place of Presentation: 京都
  • Year and Date: 2009-07-11
• [Presentation] 咽頭がん細胞KCP-4のシスプラチン耐性機序の解明 (2009)
  • Author(s): 大磯茂, 武田泰生, 山田勝士, 他
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2009-03-28
• [Presentation] 肺腺がん細胞における神経細胞接着分子コンタクチンのシグナル伝達機構の解析 (2009)
  • Author(s): 益田将吾, 武田泰生, 山田勝士, 他
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2009-03-27
• [Presentation] バンコマイシン初回投与設計における種々の腎機能 (2009)
  • Author(s): 武田泰生, 山田勝士, 他
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2009-03-26
• [Presentation] 新規行動評価を用いた向精神薬の評価法 (2009)
  • Author(s): 武田泰生, 山田勝土, 他
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: パシフイコ横浜(横浜市)
  • Year and Date: 2009-03-18
• [Presentation] (2009)
  • Author(s): 田實裕介、池田龍二、岩下建一、武田泰生、山田勝士
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-03-17
• [Presentation] 高浸透圧ストレスによるMajor Vault Protein (MVP)の発現亢進機構 (2009)
  • Author(s): 田實裕介, 武田泰生, 山田勝士, 他
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: パシフイコ横浜(横浜市)
  • Year and Date: 2009-03-17
• [Presentation] 神経接着分子コンタクチンを介した癌浸潤・転移機構の解析 (2009)
  • Author(s): 武田泰生, 益田将吾, 二川俊隆, 西田健太朗, 田畑祥, 藤井寛樹, 山田勝士
  • Organizer: 医療薬学フォーラム2009/第17回クリニカルファーマシーシンポジウム
  • Place of Presentation: 国立京都国際会館
• [Presentation] Molecular mechanism for anti-cancer drug paclitaxel-induced neuropathic pain. -behavior and microaray analyses- (2009)
  • Author(s): 武田泰生, 西田健太朗, 山田勝士
  • Organizer: Asian Federation for Pharmaceutical Sciences 2009
  • Place of Presentation: 九州大学百年記念会堂
• [Presentation] 咽頭がん細胞KCP-4のシスプラチン耐性への細胞内シグナル伝達系の関与 (2009)
  • Author(s): 大磯茂, 池田龍二, 中村和男, 武田泰生, 秋山伸一, 山田勝士, 仮谷薗博子
  • Organizer: 第19回日本医療薬学会年会
  • Place of Presentation: 長崎ブリックホール
• [Presentation] Contactin associated protein 1(Caspr1)の機能解析 (2009)
  • Author(s): 藤井寛樹, 二川俊隆, 益田将吾, 石原義久, 鬼丸貴裕, 末廣淑子, 山口沙織, 武田泰生, 山田勝士
  • Organizer: 第26回日本薬学会九州支部大会
  • Place of Presentation: 九州大学薬学部(福岡)
• [Presentation] フルオロウラシルがSN38の回腸における吸収に及ぼす影響 (2008)
  • Author(s): 柴山良彦, 武田泰生, 山田勝士, 他
  • Organizer: 第25回日本薬学会九州支部大会
  • Place of Presentation: 九州保健福祉大学(延岡市)
  • Year and Date: 2008-12-06
• [Presentation] シスプラチン耐性咽頭がん細胞KCP-4におけるABCトランスポーターの発現解析 (2008)
  • Author(s): 大磯茂, 武田泰生, 山田勝士, 他
  • Organizer: 第25回日本薬学会九州支部大会
  • Place of Presentation: 九州保健福祉大学(延岡市)
  • Year and Date: 2008-12-06
• [Presentation] がん細胞における神経細胞接着分子コンタクチンのシグナル伝達機構の解析 (2008)
  • Author(s): 益田将吾, 武田泰生, 山田勝士, 他
  • Organizer: 第25回日本薬学会九州支部大会
  • Place of Presentation: 九州保健福祉大学(延岡市)
  • Year and Date: 2008-12-06
• [Presentation] 高浸透圧によって誘導されるアポトーシスのMajor Vault Protein (MVP)による抑制機構 (2008)
  • Author(s): 田實裕介, 武田泰生, 山田勝士, 他
  • Organizer: 第25回日本薬学会九州支部大会
  • Place of Presentation: 九州保健福祉大学(延岡市)
  • Year and Date: 2008-12-06
• [Presentation] (2008)
  • Author(s): Ikeda R., Takeda Y., Akiyama, S., Yamada K.
  • Organizer: 22^<nd> Federation of Asian Pharmaceutical Association Congress
  • Place of Presentation: Singapore
  • Year and Date: 2008-11-08
• [Presentation] (2008)
  • Author(s): 武田泰生,西田健太朗, 山田勝士
  • Organizer: The 19^<th> Korea-Japan Joint Seminar on Pharmacology
  • Place of Presentation: Busan
  • Year and Date: 2008-11-07
• [Presentation] Microarray analysis on gene expressions regarding to neuropathic pain induced by anti-cancer drug paclitaxel (2008)
  • Author(s): Takeda, Y., Nishida, K., Yamada, R., et al.
  • Organizer: The 19th Korea-Japan Joint Seminar of Pharmacology
  • Place of Presentation: BEXCO Convention Hall, 釜山(韓国)
  • Year and Date: 2008-11-07
• [Presentation] A TAG-l/APP signalling pathway through Fe65 negatively modulates neurogenesis (2008)
  • Author(s): Futagawa, T., Takeda, Y. Yamada, K., et al.
  • Organizer: The 19th Korea-Japan Joint Seminar of Pharmacology
  • Place of Presentation: BEXCO Convention Hall, 釜山(韓国)
  • Year and Date: 2008-11-07
• [Presentation] Major vault protein negatively regulates hypoxia-inducible factor-lα protein levels in ACHN human renal adenocarcinoma cells under hypoxic conditions (2008)
  • Author(s): Iwashita, K., Takeda, Y. Yamada, K, et al.
  • Organizer: The 19th Korea-Japan Joint Seminar of Pharmacology
  • Place of Presentation: BEXCO Convention Hall, 釜山(韓国)
  • Year and Date: 2008-11-07
• [Presentation] The role of NF-κB on the enhanced expression of interleukin-8in thymidine phosphorylase-expressing tumor cells (2008)
  • Author(s): Tabata, S., Takeda, Y. Yamada, K, et al.
  • Organizer: The 19th Korea-Japan Joint Seminar of Pharmacology
  • Place of Presentation: BEXCO Conbention Hall, 釜山(韓国)
  • Year and Date: 2008-11-07
• [Presentation] MRSA感染者患者に対するティコプラニンの初期投与設計 (2008)
  • Author(s): 松元一明, 武田泰生, 山田勝士, 他
  • Organizer: 第32回日本薬物動態学会年会
  • Place of Presentation: 熊本市民会館(熊本市)
  • Year and Date: 2008-10-31
• [Presentation] Microarray analysis in the dorsal root ganglion of rats with ppaditaxel-induced neuropathy (2008)
  • Author(s): Takeda, Y., Nishida, K., Yamada, K., et al.
  • Organizer: 第51回日本神経化学大会
  • Place of Presentation: 富山国際会議場(富山市)
  • Year and Date: 2008-09-12
• [Presentation] (2008)
  • Author(s): 武田泰生
  • Organizer: 68^<th> International Congress of FIP
  • Place of Presentation: Basel, Switzerland
  • Year and Date: 2008-09-03
• [Presentation] シクロスポリンおよびタクロリムスのTherapeutic PK-PD Monitoringソフトウェアの構築による投与支援の試み (2008)
  • Author(s): 金子 生, 武田泰生, 山田勝士, 他
  • Organizer: 第25回日本TDM学会・学術大会
  • Place of Presentation: タワーホール船堀(東京)
  • Year and Date: 2008-06-21
• [Presentation] TDM介入によるティコプラニンの効果的投与法について (2008)
  • Author(s): 福永直子, 武田泰生, 山田勝士, 他
  • Organizer: 第25回日本TDM学会・学術大会
  • Place of Presentation: タワーホール船堀(東京)
  • Year and Date: 2008-06-21
• [Presentation] CYP2C19の遺伝子多型解析に基づくボリコナソールのpharmacodynamic S (2008)
  • Author(s): 松元一明, 武田泰生, 山田勝士, 他
  • Organizer: 第25回日本TDM学会・学術大会
  • Place of Presentation: タワーホール船堀(東京)
  • Year and Date: 2008-06-21
• [Presentation] (2008)
  • Author(s): 重永明恵、屋地慶子、上野恵、下堂薗権洋、武田泰生、山田勝士
  • Organizer: 医療薬学フォーラム2008年7月12日
  • Place of Presentation: 東京
• [Book] カッツング薬理学【原著10版】 (2009)
  • Author(s): 武田泰生、他
  • Publisher: 丸善出版
• [Book] カッツング薬理学原書「第10版」(1)向精神病薬とリチウム、(2)抗うつ薬、(3)薬物動態学と薬力学、(4)薬物の生体内変換(変化)の4項目について翻訳執筆 (2009)
  • Author(s): 武田泰生, 山田勝士, 他(分担執筆)
  • Total Pages: 64
  • Publisher: 丸善
• [Book] パートナー形態機能学 (2008)
  • Author(s): 武田泰生、他
  • Publisher: 南山堂出版
• [Book] 病気と薬パーフェクトBOOK 2008 (2008)
  • Author(s): 武田泰生、他
  • Publisher: 南山堂出版