Study on the relationship between dermal structure and disposition of tacrolimus in skin after the topical application
| Project/Area Number |
20590152
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Josai University |
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Principal Investigator |
SEKI Toshinobu Josai University, 薬学部, 教授 (60196946)
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| Co-Investigator(Renkei-kenkyūsha) |
EGAWA Yuya 城西大学, 薬学部・薬学科, 助教 (90400267)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | タクロリムス / 経皮吸収 / 動物実験代替法 / 皮膚内動態 / マイクロダイアリシス / 皮膚代替物 / 人工皮膚モデル / 皮膚内薬物動態 |
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| Research Abstract |
In vitro permeation experiments using excised rat skin and new established skin models consisted of laminated artificial membranes were used to examine disposition of tacrolimus after the topical application. Tacrolimus permeated through the skin via aqueous channel in the damaged skin and the channel was controlled by tight junction structures. Skin components and leaching serum proteins influenced the transfer rate of tacrolimus in skin.
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Report
(4 results)
Research Products
(18 results)
