Development of brain specific drug delivery system with microglia
| Project/Area Number |
20590153
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Iwate Medical University |
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Principal Investigator |
MAEDA Tomoji Iwate Medical University, 薬学部, 准教授 (60303294)
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| Co-Investigator(Renkei-kenkyūsha) |
KOMANO Hiroto 岩手医科大学, 薬学部, 教授 (40170378)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ミクログリア / ドラッグデリバリーシステム / トランスポーター / DDS / 血液脳関門 / 接着因子 / 血液脳関 / ATP / 走化性因子 / 脳毛細血管内皮細胞 |
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| Research Abstract |
In this study, we investigated the possibility whether microglia can be used for brain-targeting drug delivery system, since it was reported that microglia is able to enter the brain from blood flow. At first, we studied the effect of nucleotides on the migration of microglia in our assay system. We found that adenosine triphosphate (ATP), thymidine triphosphate (TTP) and cytidine triphosphate (CTP) induced the migration of microglia.
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Report
(4 results)
Research Products
(4 results)
