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Construction of Next Generation Type Drugs Delivery System and Development to Order-made Medicine

Research Project

Project/Area Number 20590155
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical pharmacy
Research InstitutionOhu University

Principal Investigator

KASHIWAGI Yoshitomo  Ohu University, 薬学部, 教授 (50204384)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords薬物送達システム / マイクロチップ / 個別化療法 / 電気信号 / バイオセンサ
Research Abstract

The drug delivery control release microchip by controlled potential or current was able to produce a possible controlled release or delay release, respectively. Of covering the surface and electrode of a microchip with each gold membrane and silicon dioxy film corrosiveness was investigated. Without receiving an influence at all during the solution of the component similar to body inside as a result, body inside a drugs delivery see the wisdom which is possible with a long time cycle as for, without being corroded, and obtained.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (33 results)

All 2011 2010 2009 2008 Other

All Journal Article (8 results) (of which Peer Reviewed: 5 results) Presentation (25 results)

  • [Journal Article] Voltammetric Behavior of Mediator-Modified Electrode by Electrochemical Polymerization of Nitroxyl Radical Precursor Containing Pyrrole Side Chain2010

    • Author(s)
      Tetsuya Ono, Makiko Tsunoda, Shigehiro Takahashi, Toshio Obata, Takanori Sone, Yoshitomo Kashiwagi
    • Journal Title

      Heterocycles 81

      Pages: 2771-2780

    • Related Report
      2010 Final Research Report
  • [Journal Article] Voltammetric Behavior of Mediator-Modified Electrode by Electrochemical Polymerization of Nitroxyl Radical Precursor Containing Pyrrole Side Chain2010

    • Author(s)
      Yoshitomo Kashiwagi, et al.
    • Journal Title

      Heterocycles

      Volume: 81 Pages: 2771-2780

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design and Preparation of Chemically Modified Electrodes for Selective Organic Electro-Preparative Synthesis2010

    • Author(s)
      Yoshitomo Kashiwagi, et al.
    • Journal Title

      Jorn. of the society of Materials Engineering for Resources of Japan 23(印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electrochemically Controlled Potential Release of Drug Using Poly (N-Bipyridinyl Salt Substituted Pyrrole) Film Electrode2010

    • Author(s)
      Yoshitomo Kashiwagi, et al.
    • Journal Title

      Drug Delivery System 25(印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electrochemically Controlled Potential Release of Drug Using Poly (N-Bipyridinyl Salt Substituted Pyrrole) Film Electrode2009

    • Author(s)
      Yoshitomo Kashiwagi, et al.
    • Journal Title

      Drug Delivery System (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protective effect of captopril and enaraprilat, angiotensin-converting enzyme inhibitors, on para-nonylphenol-induced・OH generation and dopamine efflux in rat striatum2008

    • Author(s)
      Toshio Obata, et al.
    • Journal Title

      Toxicology 250

      Pages: 96-99

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Voltammetric Behavior of Mediator Modified Electrode by Electrochemical Copolymerization of Nitroxyl Radical Precursor Containing Pyrrole Side Chain and Thiophenes

    • Author(s)
      Yoshitomo Kashiwagi, Makiko Tsunoda, Takanori Sone, Tetsuya Ono
    • Journal Title

      New J.Chem in press

    • NAID

      40019041516

    • Related Report
      2010 Final Research Report
  • [Journal Article] Electrocatalytic Oxidation of Amine on a Mediator Modified Electrode by Electrochemical Copolymerization of Nitroxyl Radical Precursor Containing Pyrrole Side Chain and Bithiophene Heterocycles

    • Author(s)
      Yoshitomo Kashiwagi, Yumiko Takamori, Tetsuya Ono
    • Journal Title

      in press

    • Related Report
      2010 Final Research Report
  • [Presentation] 各種ニトロキシルラジカル類の電極反応挙動とアルコール類の電解触媒酸化能に関する評価2011

    • Author(s)
      柏木良友、柴崎有理慧、小野哲也
    • Organizer
      日本薬学会第131回年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] PQQ-酵素複合修飾電極の作製とカルボン酸類の電解触媒還元反応への応用2011

    • Author(s)
      柏木良友、田中恵梨、小野哲也
    • Organizer
      日本薬学会第131回年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 電解重合法により作製したニトロキシルラジカル置換ピロール固定化電極を用いたアミン類の電解触媒酸化反応2011

    • Author(s)
      柏木良友、高森由美子、小野哲也
    • Organizer
      日本薬学会第131回年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 電気刺激応答型高分子の作製とその応用2010

    • Author(s)
      柏木良友
    • Organizer
      平成22年度第2回機能性材料・製造プロセス研究会
    • Place of Presentation
      郡山
    • Year and Date
      2010-11-05
    • Related Report
      2010 Final Research Report
  • [Presentation] 各種ニトロキシルラジカル類の電極反応挙動とアルコール類の電解触媒酸化能に関する評価2010

    • Author(s)
      柏木良友、柴崎有理慧、小野哲也
    • Organizer
      第49回日本薬学会東北支部大会
    • Place of Presentation
      郡山
    • Year and Date
      2010-10-24
    • Related Report
      2010 Final Research Report
  • [Presentation] PQQ-酵素複合修飾電極の作製とカルボン酸類の電解触媒還元反応への応用2010

    • Author(s)
      柏木良友、田中恵梨、小野哲也
    • Organizer
      第49回日本薬学会東北支部大会
    • Place of Presentation
      郡山
    • Year and Date
      2010-10-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 電解重合法により作製したニトロキシルラジカル置換ピロール固定化電極を用いたアミン類の電解触媒酸化反応2010

    • Author(s)
      柏木良友、高森由美子、小野哲也、曽根孝範
    • Organizer
      第49回日本薬学会東北支部大会
    • Place of Presentation
      郡山
    • Year and Date
      2010-10-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 電解重合法により作製したニトロキシルラジカル置換ピロール固定化電極を用いたアミン類の電解触媒酸化反応2010

    • Author(s)
      柏木良友
    • Organizer
      第49回日本薬学会東北支部大会
    • Place of Presentation
      奥羽大学 (郡山)
    • Year and Date
      2010-10-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] PQQ-酵素複合修飾電極の作製とカルボン酸類の電解触媒還元反応への応用2010

    • Author(s)
      柏木良友
    • Organizer
      第49回日本薬学会東北支部大会
    • Place of Presentation
      奥羽大学 (郡山)
    • Year and Date
      2010-10-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 各種ニトロキシルラジカル類の電極反応挙動とアルコール類に対する電解触媒還元能に関する評価2010

    • Author(s)
      柏木良友
    • Organizer
      第49回日本薬学会東北支部大会
    • Place of Presentation
      奥羽大学 (郡山)
    • Year and Date
      2010-10-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 電解重合法により作製したニトロキシルラジカル置換ピロール固定化電極を用いたアミン類の電解触媒酸化反応2010

    • Author(s)
      柏木良友、高森由美子、小野哲也、曽根孝範
    • Organizer
      第40回複素環化学討論会
    • Place of Presentation
      仙台
    • Year and Date
      2010-10-14
    • Related Report
      2010 Final Research Report
  • [Presentation] 電解重合法により作製したニトロキシルラジカル置換ピロール固定化電極の電極反応挙動2010

    • Author(s)
      柏木良友、高橋成周、小野哲也
    • Organizer
      日本薬学会130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] TEMPO 修飾ポリアクリル酸を用いた交互累積膜の電気応答による崩壊制御2010

    • Author(s)
      柏木良友、高橋成周、小野哲也
    • Organizer
      日本薬学会130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 電解重合により作製したニトロキシルラジカル置換ピロール固定化電極の電極反応挙動2010

    • Author(s)
      柏木良友
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山大学(岡山)
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] TEMPO修飾ポリアクリル酸を用いた交互累積膜の電気応答崩壊制御2010

    • Author(s)
      柏木良友
    • Organizer
      日本薬学会第1130年会
    • Place of Presentation
      岡山大学(岡山)
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] Design and Preparation of Chemically Modified Electrodes for Selective Organic Electro-Preparative Synthesis2009

    • Author(s)
      Yoshitomo Kashiwagi, Tetsuo Osa, Uichi Akiba
    • Organizer
      The sixth International Conference on Materials Engineering for Resources (ICMR2009 AKITA)
    • Place of Presentation
      秋田
    • Year and Date
      2009-10-21
    • Related Report
      2010 Final Research Report
  • [Presentation] Design and Preparation of Chemically Modified Electrodes for Selective Organic Electro-Preparative Synthesis2009

    • Author(s)
      Yoshitomo Kashiwagi
    • Organizer
      The sixth International Conference on Materials Engineering for Resources (ICMR2009 AKITA)
    • Place of Presentation
      秋田ビューホテル(秋田)
    • Year and Date
      2009-10-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] ニトロキシルラジカル置換ピロールとチオフェン類の電解共重合膜の作製とその評価2009

    • Author(s)
      柏木良友、小野哲也、角田麻希子、高橋成周、小畑俊男
    • Organizer
      第48回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Year and Date
      2009-10-18
    • Related Report
      2010 Final Research Report
  • [Presentation] ニトロキシルラジカル置換ピロールとチオフェン類の電解共重合膜の作製とその評価2009

    • Author(s)
      柏木良友
    • Organizer
      第48回日本楽学会東北支部大会
    • Place of Presentation
      東北薬科大学(仙台)
    • Year and Date
      2009-10-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] TEMOPO 修飾高分子交互累積膜を用いたインスリン放出制御2009

    • Author(s)
      柏木良友、高橋成周、小野哲也
    • Organizer
      みちのく分析科学シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2009-07-25
    • Related Report
      2010 Final Research Report
  • [Presentation] TEMPO修飾高分子交互累積膜を用いたインスリン放出制御2009

    • Author(s)
      柏木良友
    • Organizer
      みちのく分析科学シンポジウム2009
    • Place of Presentation
      東北大学青葉記念会館(仙台)
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 電気応答によるTEMPO 含有交互累積膜の崩壊制御2009

    • Author(s)
      柏木良友、高橋成周、小畑俊男、安斉順一
    • Organizer
      日本薬学会129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-27
    • Related Report
      2010 Final Research Report
  • [Presentation] イミダゾール型ニトロキシルラジカルの電極反応挙動とアルコール電解触媒酸化反応への応用2009

    • Author(s)
      柏木良友、小野哲也
    • Organizer
      日本薬学会129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-27
    • Related Report
      2010 Final Research Report
  • [Presentation] イミダゾリン型ニトロキシルラジカルの電極反応挙動とアルコール電解触媒酸化反応への応用2009

    • Author(s)
      小野哲也, 柏木良友
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-03-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] 電気応答によるTEMPO含有交互累積膜の崩壊制御2009

    • Author(s)
      高橋成周, 柏木良友, 小畑俊男, 安斉順一
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-03-27
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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