Influence of CYP2D6, CYP3A4/5 & Sulfotransferase 1A1 polymorphism on the pharmacokinetics of Tamoxifen.

• Project/Area Number: 20590156
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Chiba Institute of Science
• Principal Investigator: KUBOTA Takahiro Chiba Institute of Science, 薬学部, 准教授 (50323580)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: オーダーメード医療 / 臨床薬学 / tamoxifen / CYP2D6 / CYP3A4/5 / SULT1A1 / genetic polymorphism / Japanese / CYP3A4 / 5

Research Abstract

We have studied the analysis of the mutant alleles CYP2D6, CYP3A4/5, and SULT1A1 enzymes, which are known to be present in Japanese individuals, on themetabolic activity of tamoxifen. In addition, we are comparing the relationship between p-nitrophenol metabolic activity and SULT1A1 genetic polymorphism using an ex vivo evaluation method in 101 healthy Japanese adults.

Research Products

• [Journal Article] Copy Number Variation in Sulfotransferase isoform 1A1 (SULT1A1) is significantly associated with enzymatic activity in Japanese subjects (2013)
  • Author(s): Xinfeng Yu, Takahiro Kubota lshwori Dhakal, Setsuo Hasegawa, Suzanne Williams, Shogo Ozawa and Susan Kadlubar
  • Journal Title: Pharmacogenomics and Personalized Medicine Volume: 6 Pages: 19-24
  • DOI: 10.2147/pgpm.s36579
  • Peer Reviewed
• [Journal Article] 要介護者の薬を取り扱う介護職が抱える問題 (2011)
  • Author(s): 久保田隆廣
  • Journal Title: 千葉科学大学紀要 Volume: 4 Pages: 81-88
  • Peer Reviewed
• [Journal Article] Novel CYP2C19 629c>a mutant gene detection in Japanese subjects and estimation of its effect on conformation. (2010)
  • Author(s): Kimura S, Hasegawa S, Kobayashi A, Yamaguchi H, Yohda M, Kubota T.
  • Journal Title: Drug Discoveries & Therapeutics 4 Pages: 412-417
  • Peer Reviewed
• [Journal Article] Thiopurine maintenance therapy for ulcerative colitis-the clinical significance of monitoring 6-thioguanine nucleotide. (2010)
  • Author(s): Hanai H, Iida T, Takeuchi K, Arai O, Watanabe F, Abe J, Maruyama Y, Oohata A, Ikeya K, Kageoka M, Miwa I, Satou Y, Hosoda Y, Kubota T.
  • Journal Title: Inflamm Bowel Dis 16 Pages: 1376-1381
  • Peer Reviewed
• [Journal Article] 新規サプリメントと医薬品の相互作用を予見する (2010)
  • Author(s): 久保田隆廣、吉岡慎一、川越信秀、豊田剛史、石橋範人、鈴木信孝
  • Journal Title: 日本補完代替医療学会誌 7 Pages: 67-74
  • NAID: 130000422871
  • Peer Reviewed
• [Journal Article] Novel CYP2C19 629c>a mutant gene detection in Japanese subjects and estimation of its effect on conformation. (2010)
  • Author(s): Kimura S, Hasegawa S, Kobayashi A, Yamaguchi H, Yohda M, Kubota T.
  • Journal Title: Drug Discoveries & Therapeutics Volume: 4 Pages: 412-417
  • Peer Reviewed
• [Journal Article] 新規サプリメントと医薬品の相互作用を予見する (2010)
  • Author(s): 久保田隆廣、吉岡慎一、川越信秀、豊田剛史、石橋範人、鈴木信孝
  • Journal Title: 日本補完代替医療学会誌 Volume: 7 Pages: 67-74
  • NAID: 130000422871
  • Peer Reviewed
• [Journal Article] Thiopurine maintenance therapy for ulcerative colitis-the clinical significance of monitoring 6-thioguanine nucleotide. (2010)
  • Author(s): Hanai H, Iida T, Takeuchi K, Arai O, Watanabe F, Abe J, Maruyama Y, Oohata A, Ikeya K, Kakeoka M, Miwa K, Satou Y, Hosoda Y, Kubota T.
  • Journal Title: Inflammatory bowel diseases (印刷中)
  • Peer Reviewed
• [Journal Article] Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercaptopurine treatment. (2009)
  • Author(s): Uchiyama K, Nakamura M, Kubota T., Yamane T, Fujise K, Tajiri H.
  • Journal Title: J Gastroenterology 44 Pages: 197-203
  • NAID: 10025173737
  • Peer Reviewed
• [Journal Article] Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohy drolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercapto purine treatment. (2009)
  • Author(s): Uchiyama K, Nakamura M, Kubota T, Yamane T, Fuiise K, Tajiri H.
  • Journal Title: Journal of Gastroenterology 44 Pages: 197-230
  • Peer Reviewed
• [Presentation] Adverse reactions of azathioprine/6-mercaptopurine treatment, thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease. (2009)
  • Author(s): 内山幹, et al.
  • Organizer: DDW (AGA)
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-05-31
• [Presentation] チオプリン製剤不耐の日本人炎症性腸疾患患者におけるThiopurine S-methyltransferaseおよびInosine triphosphate pyrophosphohydrolase遺伝子の検討 (2009)
  • Author(s): 内山幹, ら
  • Organizer: 第95回日本消化器病学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2009-05-08
• [Presentation] チオプリン製剤不耐の日本人炎症性腸疾患患者におけるThiopurine S-methyl transferaseおよびInosine triphosphate pyrophosphohydrolase遺伝子の検討 (2009)
  • Author(s): 内山幹、小田原俊一、久保田隆廣、小井戸薫雄、山根建樹、大草敏史、田尻久雄
  • Organizer: 日本消化器病学会
  • Place of Presentation: 札幌
  • Year and Date: 2009-05-08
• [Presentation] Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohy drolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercapto purine treatment. (2008)
  • Author(s): Kubota T, Uchiyama K
  • Organizer: EHRLICH II, 2nd World Conference.
  • Place of Presentation: Nurnberg@Germany
  • Year and Date: 2008-10-04
• [Presentation] Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercaptopurine treatment. (2008)
  • Author(s): T. Kubota, et al.
  • Organizer: EHRLICH II, 2nd World Conference.
  • Place of Presentation: Nurnberg, Germany
• [Book] 確認テストと症例解析で身につける薬物速度論入門 (2010)
  • Author(s): 久保田隆廣, 菅谷誠, 坂本新子
  • Total Pages: 71
  • Publisher: 医薬ジャーナル社
• [Book] 確認テストと症例解析で身につける薬物速度論入門 (2010)
  • Author(s): 久保田隆廣、菅谷誠、坂本新子
  • Total Pages: 71
  • Publisher: 医薬ジャーナル社