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Influence of CYP2D6, CYP3A4/5 & Sulfotransferase 1A1 polymorphism on the pharmacokinetics of Tamoxifen.

Research Project

Project/Area Number 20590156
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical pharmacy
Research InstitutionChiba Institute of Science

Principal Investigator

KUBOTA Takahiro  Chiba Institute of Science, 薬学部, 准教授 (50323580)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsオーダーメード医療 / 臨床薬学 / tamoxifen / CYP2D6 / CYP3A4/5 / SULT1A1 / genetic polymorphism / Japanese / CYP3A4 / 5
Research Abstract

We have studied the analysis of the mutant alleles CYP2D6, CYP3A4/5, and SULT1A1 enzymes, which are known to be present in Japanese individuals, on themetabolic activity of tamoxifen. In addition, we are comparing the relationship between p-nitrophenol metabolic activity and SULT1A1 genetic polymorphism using an ex vivo evaluation method in 101 healthy Japanese adults.

Report

(5 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Products Report
  • Research Products

    (17 results)

All 2013 2011 2010 2009 2008

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (5 results) Book (2 results)

  • [Journal Article] Copy Number Variation in Sulfotransferase isoform 1A1 (SULT1A1) is significantly associated with enzymatic activity in Japanese subjects2013

    • Author(s)
      Xinfeng Yu, Takahiro Kubota lshwori Dhakal, Setsuo Hasegawa, Suzanne Williams, Shogo Ozawa and Susan Kadlubar
    • Journal Title

      Pharmacogenomics and Personalized Medicine

      Volume: 6 Pages: 19-24

    • DOI

      10.2147/pgpm.s36579

    • Related Report
      Products Report
    • Peer Reviewed
  • [Journal Article] 要介護者の薬を取り扱う介護職が抱える問題2011

    • Author(s)
      久保田隆廣
    • Journal Title

      千葉科学大学紀要

      Volume: 4 Pages: 81-88

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel CYP2C19 629c>a mutant gene detection in Japanese subjects and estimation of its effect on conformation.2010

    • Author(s)
      Kimura S, Hasegawa S, Kobayashi A, Yamaguchi H, Yohda M, Kubota T.
    • Journal Title

      Drug Discoveries & Therapeutics 4

      Pages: 412-417

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thiopurine maintenance therapy for ulcerative colitis-the clinical significance of monitoring 6-thioguanine nucleotide.2010

    • Author(s)
      Hanai H, Iida T, Takeuchi K, Arai O, Watanabe F, Abe J, Maruyama Y, Oohata A, Ikeya K, Kageoka M, Miwa I, Satou Y, Hosoda Y, Kubota T.
    • Journal Title

      Inflamm Bowel Dis 16

      Pages: 1376-1381

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 新規サプリメントと医薬品の相互作用を予見する2010

    • Author(s)
      久保田隆廣、吉岡慎一、川越信秀、豊田剛史、石橋範人、鈴木信孝
    • Journal Title

      日本補完代替医療学会誌 7

      Pages: 67-74

    • NAID

      130000422871

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel CYP2C19 629c>a mutant gene detection in Japanese subjects and estimation of its effect on conformation.2010

    • Author(s)
      Kimura S, Hasegawa S, Kobayashi A, Yamaguchi H, Yohda M, Kubota T.
    • Journal Title

      Drug Discoveries & Therapeutics

      Volume: 4 Pages: 412-417

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新規サプリメントと医薬品の相互作用を予見する2010

    • Author(s)
      久保田隆廣、吉岡慎一、川越信秀、豊田剛史、石橋範人、鈴木信孝
    • Journal Title

      日本補完代替医療学会誌

      Volume: 7 Pages: 67-74

    • NAID

      130000422871

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thiopurine maintenance therapy for ulcerative colitis-the clinical significance of monitoring 6-thioguanine nucleotide.2010

    • Author(s)
      Hanai H, Iida T, Takeuchi K, Arai O, Watanabe F, Abe J, Maruyama Y, Oohata A, Ikeya K, Kakeoka M, Miwa K, Satou Y, Hosoda Y, Kubota T.
    • Journal Title

      Inflammatory bowel diseases (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercaptopurine treatment.2009

    • Author(s)
      Uchiyama K, Nakamura M, Kubota T., Yamane T, Fujise K, Tajiri H.
    • Journal Title

      J Gastroenterology 44

      Pages: 197-203

    • NAID

      10025173737

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohy drolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercapto purine treatment.2009

    • Author(s)
      Uchiyama K, Nakamura M, Kubota T, Yamane T, Fuiise K, Tajiri H.
    • Journal Title

      Journal of Gastroenterology 44

      Pages: 197-230

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Adverse reactions of azathioprine/6-mercaptopurine treatment, thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease.2009

    • Author(s)
      内山幹, et al.
    • Organizer
      DDW (AGA)
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2009-05-31
    • Related Report
      2010 Final Research Report
  • [Presentation] チオプリン製剤不耐の日本人炎症性腸疾患患者におけるThiopurine S-methyltransferaseおよびInosine triphosphate pyrophosphohydrolase遺伝子の検討2009

    • Author(s)
      内山幹, ら
    • Organizer
      第95回日本消化器病学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2009-05-08
    • Related Report
      2010 Final Research Report
  • [Presentation] チオプリン製剤不耐の日本人炎症性腸疾患患者におけるThiopurine S-methyl transferaseおよびInosine triphosphate pyrophosphohydrolase遺伝子の検討2009

    • Author(s)
      内山幹、小田原俊一、久保田隆廣、小井戸薫雄、山根建樹、大草敏史、田尻久雄
    • Organizer
      日本消化器病学会
    • Place of Presentation
      札幌
    • Year and Date
      2009-05-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohy drolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercapto purine treatment.2008

    • Author(s)
      Kubota T, Uchiyama K
    • Organizer
      EHRLICH II, 2nd World Conference.
    • Place of Presentation
      Nurnberg@Germany
    • Year and Date
      2008-10-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercaptopurine treatment.2008

    • Author(s)
      T. Kubota, et al.
    • Organizer
      EHRLICH II, 2nd World Conference.
    • Place of Presentation
      Nurnberg, Germany
    • Related Report
      2010 Final Research Report
  • [Book] 確認テストと症例解析で身につける薬物速度論入門2010

    • Author(s)
      久保田隆廣, 菅谷誠, 坂本新子
    • Total Pages
      71
    • Publisher
      医薬ジャーナル社
    • Related Report
      2010 Final Research Report
  • [Book] 確認テストと症例解析で身につける薬物速度論入門2010

    • Author(s)
      久保田隆廣、菅谷誠、坂本新子
    • Total Pages
      71
    • Publisher
      医薬ジャーナル社
    • Related Report
      2010 Annual Research Report

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Published: 2008-04-01   Modified: 2016-09-09  

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