Influence of CYP2D6, CYP3A4/5 & Sulfotransferase 1A1 polymorphism on the pharmacokinetics of Tamoxifen.
Project/Area Number |
20590156
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Medical pharmacy
|
Research Institution | Chiba Institute of Science |
Principal Investigator |
KUBOTA Takahiro Chiba Institute of Science, 薬学部, 准教授 (50323580)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | オーダーメード医療 / 臨床薬学 / tamoxifen / CYP2D6 / CYP3A4/5 / SULT1A1 / genetic polymorphism / Japanese / CYP3A4 / 5 |
Research Abstract |
We have studied the analysis of the mutant alleles CYP2D6, CYP3A4/5, and SULT1A1 enzymes, which are known to be present in Japanese individuals, on themetabolic activity of tamoxifen. In addition, we are comparing the relationship between p-nitrophenol metabolic activity and SULT1A1 genetic polymorphism using an ex vivo evaluation method in 101 healthy Japanese adults.
|
Report
(5 results)
Research Products
(17 results)
-
-
-
-
[Journal Article] Thiopurine maintenance therapy for ulcerative colitis-the clinical significance of monitoring 6-thioguanine nucleotide.2010
Author(s)
Hanai H, Iida T, Takeuchi K, Arai O, Watanabe F, Abe J, Maruyama Y, Oohata A, Ikeya K, Kageoka M, Miwa I, Satou Y, Hosoda Y, Kubota T.
-
Journal Title
Inflamm Bowel Dis 16
Pages: 1376-1381
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Thiopurine maintenance therapy for ulcerative colitis-the clinical significance of monitoring 6-thioguanine nucleotide.2010
Author(s)
Hanai H, Iida T, Takeuchi K, Arai O, Watanabe F, Abe J, Maruyama Y, Oohata A, Ikeya K, Kakeoka M, Miwa K, Satou Y, Hosoda Y, Kubota T.
-
Journal Title
Inflammatory bowel diseases (印刷中)
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-