Th1/Th2 balance as a determinant of drug-induced liver injury
| Project/Area Number |
20590157
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Medical pharmacy
|
|---|
| Research Institution | Chiba Institute of Science |
|---|
Principal Investigator |
MASUBUCHI Yasuhiro Chiba Institute of Science, 薬学部, 教授 (10209455)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 副作用 / 薬剤性肝障害 / Th1 / Th2 / アセトアミノフェン / マウス / N-アセチルシステイン / インターロイキン-6 / グルタチオン / Th1/Th2 / N-フセチルシステイン / 炎症性サイトカイン / TNF-< / TNF-α |
|---|
| Research Abstract |
Studies on susceptible and resistant mouse strains demonstrated that acetaminophen-induced liver injury was associated with Th1-dominant response in Th1/Th2 cytokine balance and increase in TNF-α/IL-6 ratio. It was confirmed by another hepatotoxicity model, which was developed by furosemide. N-Acetylcysteine and glutathione were found to exert their hepatoprotective effects via mechanisms that are independent of increasing hepatic glutathione, but probably act through improvement of Th1/Th2 balance.
|
Report
(4 results)
Research Products
(22 results)
