Regulatory role of ezrin on transportsome at the blood placenta barrier

• Project/Area Number: 20590158
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Keio University
• Principal Investigator: SAI Yoshimichi Keio University, 附属病院, 准教授 (40262589)
• Co-Investigator(Kenkyū-buntansha): NISHIMURA Tomohiro 慶應義塾大学, 薬学部, 助教 (40453518)
• Co-Investigator(Renkei-kenkyūsha): WAKAYAMA Tomohiko 金沢大学, 医学系, 准教授 (70305100)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: トランスポーター / 生体膜輸送 / 胎盤関門 / 妊娠時薬物療法 / トロホブラスト / 異物認識 / タンパク質間相互作用 / 薬物間相互作用 / 薬物相互作用

Research Abstract

This study was aimed to clarify the regulatory role of ezrin on transporter complex (transportsome) at the placenta barrier. Our study using syncytiotrophoblast cell line TR-TBTs, pregnant rats as well as knockout mice lacking ezrin, scaffold protein that links membrane proteins to the cortical actin, have suggested that ezrin is located at the apical membrane of syncytiotrophoblasts during the course of pregnancy and works as a functional regulator in the transportsome containing a hypotaurin transporter Slc6a13.

Research Products

• [Journal Article] 6-Mercaptopurine transport by equilibrative nucleoside transporters in conditionally immortalized rat syncytiotrophoblast cell lines TR-TBTs. (2011)
  • Author(s): Lee NY, Sai Y, Nakashima E, Ohtsuki S, Terasaki T, Kang YS.
  • Journal Title: Pharm Sci 100(9)(in press)
  • Peer Reviewed
• [Journal Article] Roles of TauT and system A in cytoprotection of rat syncytiotrophoblast cell line exposed to hypertonic stress. (2010)
  • Author(s): Nishimura T, Sai Y, Fujii, Muta M, Iizasa H, Tomi M, Kose N, Nakashima E.
  • Journal Title: Placenta 31(11) Pages: 1003-1009
  • Peer Reviewed
• [Journal Article] Proton-coupled erythromycin antiport at rat blood-placenta barrier. (2010)
  • Author(s): Sai Y, Nishimura T, Ochi K, Tanaka N, Takagi A, Tomi M, Kose N, Kobayashi Y, Miyakoshi N, Kitagaki S, Mukai C, Nakashima E.
  • Journal Title: Drug Metab Dispos 38(9) Pages: 1576-1581
  • Peer Reviewed
• [Journal Article] Differential expression of Ezrin and CLP-36 in two layers of syncytiotrophoblast in rats. (2010)
  • Author(s): Higuchi K, Iizasa H, Sai Y, Horieya S, Lee K-E, Wada M, Nishimura T, Wakayama T, Tamura A, Tsukita S, Kose N, Kang Y-S, Nakashima E.
  • Journal Title: Biol Pharm Bull 33(8) Pages: 1400-1406
  • NAID: 130000300367
  • Peer Reviewed
• [Journal Article] Differential expression of Ezrin and CLP-36 in two layers of syncytiotro phoblast in rats. (2010)
  • Author(s): Higuchi K, Iizasa H, Sai Y, Horieya S, Lee K-E, Wada M, Nishimura T, Wakayama T, Tamura A, Tsukita S, Kose N, Kang Y-S, Nakashima E.
  • Journal Title: Biol Pharm Bull Volume: 33 Pages: 1400-1406
  • NAID: 130000300367
  • Peer Reviewed
• [Journal Article] Proton-coupled erythromycin antiport at rat blood-placenta barrier (2010)
  • Author(s): Sai Y, Nishimura T, Ochi K, Tanaka N, Takagi A, Tomi M, Kose N, Kobayashi Y, Miyakoshi N, Kitagaki S, Mukai C, Nakashima E
  • Journal Title: Drug Metab Diepae Volume: 38 Pages: 1576-1581
  • Peer Reviewed
• [Journal Article] Roles of TauT and system A in cytoprotection of rat syncytiotrophoblast cell line exposed to hypertonic stress (2010)
  • Author(s): Nishimura T, Sai Y, Fujii, MutaM, Iizasa H, Tomi M, Kose N, Nakashima E
  • Journal Title: Placenta Volume: 31 Pages: 1003-1009
  • Peer Reviewed
• [Journal Article] (2010)
  • Author(s): 玉井郁巳, 崔吉道
  • Journal Title: 生物薬科学実験講座5、細胞の構造とオルガネラ(廣川書店) Pages: 104-116
• [Journal Article] Expression, localization and binding activity of the ezrin/radixin/moesin proteins in the mouse testis. (2009)
  • Author(s): Wakayama T, Nakata H, Kurobo M, Sai Y, Iseki S.
  • Journal Title: Histochem Cytochem 57(4) Pages: 351-362
  • Peer Reviewed
• [Journal Article] Influx mechanism of 2', 3'-dideoxyinosine(ddI)and uridine at the blood-placenta barrier. (2009)
  • Author(s): Sato K, Sai Y, Nishimura T, Chishu T, Kose N, Nakashima E.
  • Journal Title: Placenta 30(3) Pages: 263-269
  • Peer Reviewed
• [Journal Article] Expression, localization and binding activity of the ezrin/radixin/moesin proteins in the mouse testis (2009)
  • Author(s): Wakayama T, Nakata H, Kurobo M, Sai Y, Iseki S
  • Journal Title: J Histochem Cytochem 57 Pages: 351-362
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 崔吉道
  • Journal Title: スタンダード薬学シリーズ6、薬と疾病、IB. 薬の効くプロセス (2) 薬剤 (第2版)(東京化学同人) Pages: 57-59
• [Journal Article] Influx mechanism of 2', 3'-dideoxyinosine (ddI) and uridine at the blood-placenta barrier (2009)
  • Author(s): Sato K, Sai Y, Nishimura T, Chishu T, Kose N, Nakashima E
  • Journal Title: Placenta 30 Pages: 263-269
  • Peer Reviewed
• [Journal Article] Enhancement of zidovudine uptake by dehydroepiandrosterone sulfate in rat syncytiotrophoblast cell line TR-TBT 18d-1. (2008)
  • Author(s): Nishimura T, Seki Y, Sato K, Chishu T, Kose N, Terasaki T, Kang YS, Sai Y, Nakashima E.
  • Journal Title: Drug Metab Dispos 36(10) Pages: 2080-2085
  • Peer Reviewed
• [Journal Article] Characterization of the mechanism of Zidovudine uptake by rat conditionally immortalized syncytiotrophoblast cell line TR-TBT. (2008)
  • Author(s): Sai Y, Nishimura T, Shimpo S, Chishu T, Sato K, Kose N, Terasaki T, Mukai C, Miyakoshi N, Kang YS, Nakashima E.
  • Journal Title: Pharm Res 25(7) Pages: 1647-1653
  • Peer Reviewed
• [Journal Article] Potential of various drugs to? inhibit nucleoside uptake in rat syncytiotrophoblast cell line, TR-TBT 18d-1. (2008)
  • Author(s): Chishu T, Sai Y, Nishimura T, Sato K, Kose N, Nakashima E.
  • Journal Title: Placenta. 29(5) Pages: 461-467
  • Peer Reviewed
• [Journal Article] Potential of various drugs to inhibit nucleoside uptake in rat syncytiotrophoblast cell line, TR-TBT 18d-1 (2008)
  • Author(s): Chishu T, Sai Y, Nishimura T, Sato K, Kose N, Nakashima E
  • Journal Title: Placenta 29 Pages: 461-467
  • Peer Reviewed
• [Journal Article] Involvement of multidrug resistance-associated protein 2 (Abcc2) in molecular weight-dependent biliary excretion of (beta)-lactam antibiotics (2008)
  • Author(s): Kato Y, Takahara S, Kato S, Kubo Y, Sai Y, Tamai I, Yabuuchi H, Tsuji A
  • Journal Title: Drug Metab Dispos 36 Pages: 1088-1096
  • Peer Reviewed
• [Journal Article] Characterization of the mechanism of Zidovudine uptake by rat conditionally immortalized syncytiotrophoblast cell line TR-TBT (2008)
  • Author(s): Sai Y, Nishimura T, Shimpo S, Chishu T, Sato K, Kose N, Terasaki T, Mukai C, Miyakoshi N, Kang YS, Nakashima E.
  • Journal Title: Pharm Res 25 Pages: 1647-1653
  • Peer Reviewed
• [Journal Article] Enhancement of zidovudine uptake by dehydroepiandrosterone sulfate in rat syncytiotrophoblast cell line TR-TBT 18d-1 (2008)
  • Author(s): Nishimura T, Seki Y, Sato K, Chishu T, Kose N, Terasaki T, Kane YS, Sai Y, Nakashima E
  • Journal Title: Drug Metab Dispos 36 Pages: 2080-2085
  • Peer Reviewed
• [Journal Article] 生体膜分子を基盤とする薬剤開発・治療に向けた新展開 (2008)
  • Author(s): 大槻純男, 崔 吉道
  • Journal Title: 薬学雑誌 128 Pages: 495-496
  • NAID: 110006656187
• [Presentation] 胎盤におけるezrinの発現とSlc6a13機能調節因子としての役割 (2010)
  • Author(s): 登美斉俊、樋口慧、西村友宏、若山友彦、田村淳、月田早智子、曽我朋義、崔吉道、中島恵美
  • Organizer: 第32回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 富山国際会議場(富山県)
  • Year and Date: 2010-11-30
• [Presentation] 胎盤におけるezrinの発現とS1c6a13機能調節因子としての役割 (2010)
  • Author(s): 登美斉俊、樋口慧、西村友宏、若山友彦、田村淳、月田早智子、曽我朋義、崔吉道、中島恵美
  • Organizer: 第32回生体膜と薬物の相互作用シンポジウム
  • Place of Presentation: 富山国際会議場(富山県)
  • Year and Date: 2010-11-29
• [Presentation] Decreased hypotaurine concentration in fetal plasma and placenta of ezrin knockout mice and Slc6a13/GAT-2-mediated hypotaurine transport in the placenta. (2010)
  • Author(s): 樋口慧, 西村友宏, 登美斉俊, 田村淳, 月田早智子, 曽我朋義, 崔吉道, 中島恵美
  • Organizer: FIP Pharmaceutical Sciences 2010 World Congress
  • Place of Presentation: Morial Convention Center(USA)
  • Year and Date: 2010-11-14
• [Presentation] ラット胎盤関門におけるエリスロマイシンのプロトン共役排出輸送 (2010)
  • Author(s): 崔吉道、西村友宏、越智香織、田中紀章、高木彰紀、登美斉俊、巨勢典子、中島恵美
  • Organizer: 第5回トランスポーター研究会
  • Place of Presentation: 東京医科大学(東京都)
  • Year and Date: 2010-07-10
• [Presentation] 胎盤hypotaurine取り込みにおけるGABAトランスーポーター(Slc6a13)の関与 (2010)
  • Author(s): 樋口慧、西村友宏、登美斉俊、巨勢典子、崔吉道、中島恵美
  • Organizer: 第5回トランスポーター研究会
  • Place of Presentation: 東京医科大学(東京都)
  • Year and Date: 2010-07-10
• [Presentation] Ezrin欠損マウス胎盤・胎児で減少するhypotaurineの胎盤におけるトランスポーター同定 (2010)
  • Author(s): 樋口慧、西村友宏、登美斉俊、若山友彦、田村淳、月田早智子、曽我朋義、崔吉道、中島恵美
  • Organizer: 日本薬剤学会第25年会
  • Place of Presentation: 徳島県郷土文化会館(徳島県)
  • Year and Date: 2010-05-12
• [Presentation] Ezrin欠損マウス胎盤・胎児で減少するhypotaurineの胎盤におけるトランスポーター同定 (2010)
  • Author(s): 樋口慧、西村友宏、登美斉俊、若山友彦、田村淳、月田早智子、曽我朋義、崔吉道、中島恵美
  • Organizer: 日本薬剤学会第25年会
  • Place of Presentation: あわぎんホール(徳島県)
  • Year and Date: 2010-05-12
• [Presentation] 薬物胎児移行と胎盤トランスポーターの機能制御 (2010)
  • Author(s): 崔吉道
  • Organizer: 第9回薬学と臨床セミナー
  • Place of Presentation: 大手町サンケイプラザ(東京都)(招待講演)
  • Year and Date: 2010-04-03
• [Presentation] 薬物胎児移行と胎盤トランスポーターの機能制御 (2010)
  • Author(s): 崔吉道
  • Organizer: 第9回薬学と臨床セミナー
  • Place of Presentation: 大手町サンケイプラザ(東京都)【招待講演】
  • Year and Date: 2010-04-03
• [Presentation] GABA輸送担体 (Slc6a13/GAT-2) を介した hypotaurine の胎盤供給機構 (2010)
  • Author(s): 樋口慧, 西村友宏, 登美斉俊, 崔吉道, 中島恵美
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山コンベンションセンター (岡山)
  • Year and Date: 2010-03-29
• [Presentation] GABA輸送担体(Slc6a13/GAT-2)を介したhypotaurineの胎盤供給機構 (2010)
  • Author(s): 樋口慧、西村友宏、登美斉俊、崔吉道、中島恵美
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山コンベンションセンター(岡山県)
  • Year and Date: 2010-03-28
• [Presentation] Decreased hypotaurine concentration in fetal plasma and placenta of ezrin knockout mice and S1c6a13/GAT-2-mediated hypotaurine transport in the placenta (2010)
  • Author(s): Higuchi K, Nishimura T, Tomi M, Tamura A, Tsuki to S, Soga T, SaiY, Nakashima E
  • Organizer: FIP Pharmaceutical Sciences 2010 World Congress
  • Place of Presentation: Morial Convention Center(USA)
• [Presentation] Enhancement of zidovudine uptake by DHEAS in CD4(+) T lymphocyte model, MOLT-4 cells (2009)
  • Author(s): Nishimura T, Seki Y, Tomi M, Tanaka J, Sai Y, Nakashima E.
  • Organizer: 第24回日本薬物動態学会年会
  • Place of Presentation: 京都国際会館 (京都府)
  • Year and Date: 2009-11-28
• [Presentation] 薬物動態の個人間変動 (2009)
  • Author(s): 崔吉道
  • Organizer: 第17回臨床薬剤師のための講習会
  • Place of Presentation: 金沢都ホテル(石川県)(特別講演)
  • Year and Date: 2009-07-05
• [Presentation] 薬物動態の個人間変動 (2009)
  • Author(s): 崔吉道
  • Organizer: 第17回 臨床薬剤師のための講習会
  • Place of Presentation: 金沢都ホテル (石川県)
  • Year and Date: 2009-07-05
• [Presentation] Distinct transport mechanisms of zidovudine and didanosine at the blood-placenta barrier (2009)
  • Author(s): Tomi M, Sato K, Sai Y, Nishimura T, Nakashima E
  • Organizer: 8th Cerebral Vascular Biology International Conference
  • Place of Presentation: Sendai Excel Hotel Tokyu (宮城県)
  • Year and Date: 2009-06-28
• [Presentation] Ezrinノックアウトによる胎児血および胎盤中生体物質濃度変化のメタボローム解析 (2009)
  • Author(s): 樋口慧、西村友宏、登美斉俊、若山友彦、田村淳、月田早智子、曽我朋義、崔吉道、中島恵美
  • Organizer: 日本薬剤学会第24年会
  • Place of Presentation: 静岡県コンベンションアーツセンター(静岡県)
  • Year and Date: 2009-05-23
• [Presentation] Ezrinノックアウトによる胎児血および胎盤中生体物質濃度変化のメタボローム解析 (2009)
  • Author(s): 樋口慧, 西村友宏, 登美斉俊, 若山友彦, 田村淳, 月田早智子, 曽我朋義, 崔吉道, 中島恵美
  • Organizer: 日本薬剤学会第24年会
  • Place of Presentation: 静岡県コンベンションアーツセンター (静岡県)
  • Year and Date: 2009-05-23
• [Presentation] エリスロマイシンの血液胎盤関門透過における排出輸送機構の関与 (2009)
  • Author(s): 西村友宏, 田中紀章, 登美斉俊, 巨勢典子, 崔吉道, 中島恵美
  • Organizer: 日本薬剤学会第24年会
  • Place of Presentation: 静岡県コンベンションアーツセンター (静岡県)
  • Year and Date: 2009-05-21
• [Presentation] H^+-Coupled efflux transport of erythromycin at the blood-placenta barrier in rats. (2009)
  • Author(s): Sai Y, Tanaka N, Takagi A, Ochi K, Nishimura T, Tomi M, Kose N, Nakashima E
  • Organizer: The 3rd Asian Pacific Regional ISSX Meeting
  • Place of Presentation: The Imperial Queen's Park Hotel(Thailand)
  • Year and Date: 2009-05-11
• [Presentation] H^+-Coupled efflux transport of erythromycin at the blood-placenta barrier in rats (2009)
  • Author(s): Sai Y, Tanaka N, Takagi A, Ochi K, Nishimura T, Tomi M, Kose N, Nakashima E
  • Organizer: The 3rd Asian Pacific Regional ISSX Meeting
  • Place of Presentation: The Imperial Queen's Park Hotel (Thailand)
  • Year and Date: 2009-05-11
• [Presentation] ラツト血液-胎盤関門におけるadenosine取り込みにENT4は関与するか? (2009)
  • Author(s): 中村 遼, 地主拓也, 西村友宏, 巨勢典子, 崔 吉道, 中島恵美
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-28
• [Presentation] エズリン欠損マウス胎盤におけるP-糖タンパク質の機能低下 (2009)
  • Author(s): 出口雅之, 樋口 慧, 和田真実, 西村友宏, 巨勢典子, 崔 吉道, 中島恵美
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-28
• [Presentation] 血液-胎盤関門でのadenosine取り込みにおけるpH依存性輸送の関与 (2008)
  • Author(s): 中村 遼, 地主拓也, 西村友宏, 巨勢典子, 崔 吉道, 中島恵美
  • Organizer: トランスポーター研究会第2回関東部会
  • Place of Presentation: 東京
  • Year and Date: 2008-12-06
• [Presentation] Ezrinノックアウトマウス胎児血漿と胎盤のメタボロミクスによる胎盤におけるezrin機能の解析 (2008)
  • Author(s): 樋口 慧, 西村友宏, 崔吉道, 若山友彦, 田村淳, 月田早智子, 曽我朋義, 中島恵美
  • Organizer: 第1回トランスポーターワークショップin鶴岡
  • Place of Presentation: 鶴岡
  • Year and Date: 2008-11-15
• [Presentation] H^+-coupled transport of erythromycin at the blood-placenta barrier in rats. (2008)
  • Author(s): Sai Y, Takagi A, Ochi K, Nishimura T, Kose N, Nakashima E
  • Organizer: 第23回日本薬物動態学会年会
  • Place of Presentation: 熊本市民会館(熊本県)
  • Year and Date: 2008-10-31
• [Presentation] H^+-coupled transport of erythromycin at the blood-placenta barrier in rats (2008)
  • Author(s): 崔 吉道, 高木彰紀, 越智香織, 西村友宏, 巨勢典子, 中島恵美
  • Organizer: 第23回日本薬物動態学会
  • Place of Presentation: 熊本
  • Year and Date: 2008-10-30
• [Presentation] Transport mechanism of purine nucleosides, adenosine and didanosine, across brush-border membrane in rat blood-placenta barrier (2008)
  • Author(s): 西村友宏, 佐藤和子, 地主拓也, 巨勢典子, 崔 吉道, 中島恵美
  • Organizer: 第23回日本薬物動態学会
  • Place of Presentation: 熊本
  • Year and Date: 2008-10-30
• [Presentation] Uptake mechanism of erythromycin at the blood-placenta barrier (2008)
  • Author(s): Sai Y, Takagi A, Ochi K, Kose N, Ni shimura T. Nakashima E
  • Organizer: FIP2008
  • Place of Presentation: Basel, Switzerland
  • Year and Date: 2008-09-01
• [Presentation] 血液-胎盤関門での2', 3'-dideoxyinosine (ddI)取り込みにおけるENT2の関与 (2008)
  • Author(s): 佐藤和子, 地主拓也, 巨勢典子, 西村友宏, 崔 吉道, 中島恵美
  • Organizer: 第3回トランスポーター研究会
  • Place of Presentation: 京都
  • Year and Date: 2008-06-06
• [Presentation] Transporter mediated approaches for delivery and avoicance control of drug to organs(Special Lecture). (2008)
  • Author(s): 崔吉道
  • Organizer: 2nd NRL Sympodium on Transporters Targeted Drug Delivery
  • Place of Presentation: Seoul National University(Korea)
  • Year and Date: 2008-05-26
• [Presentation] Transporter mediated approaches for delivery and avoicancecontrol of drug to organs (2008)
  • Author(s): Yoshimichi Sai
  • Organizer: 2nd NRL Sympodium on Transporters Targeted Drug Delivery
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2008-05-26
• [Presentation] DHEASによるラット胎盤trophoblast細胞のzidovudine取り込み促進 (2008)
  • Author(s): 関 善彬, 西村友宏, 巨勢典子, 崔 吉道, 中島恵美
  • Organizer: 日本薬剤学会第23年会
  • Place of Presentation: 札幌
  • Year and Date: 2008-05-22
• [Presentation] 2', 3'-Dideoxyinosine (ddI) and uridine share an equilibrative nucleoside transporter (ENT2) on these uptakes at the blood-placenta barrier (BPB) (2008)
  • Author(s): Sato K, Sai Y, Nishimura T, Kose N, Nakashima E
  • Organizer: The 2nd Asian Pacific Regional ISSX Meeting
  • Place of Presentation: Shanghai, China
  • Year and Date: 2008-05-13
• [Presentation] Identification of equilibrative nucleoside transporters involving nucleoside and nucleobase uptakes in rat placental cell line, TR-TBT 18d-1 (2008)
  • Author(s): Chishu T, Nishimura T, Kose N, Sai Y, Nakashima E
  • Organizer: The 2nd Asian Pacific Regional ISSX Meeting
  • Place of Presentation: Shanghai, China
  • Year and Date: 2008-05-13
• [Presentation] Role of transporters on phathophysiological aspect of the blood-placenta barrier. (2008)
  • Author(s): Sai Y, Higuchi K, Sato K, Chishu T, Nishimura T, Nakashima E
  • Organizer: The Pharmaceutical Society of Korea 2008 Spring International Convention
  • Place of Presentation: International Convention Center Jeju(Korea)(シンポジウム講演)
  • Year and Date: 2008-05-02
• [Presentation] Role of transporters on phathophysiological aspect of the blood-placenta barrier (2008)
  • Author(s): Yoshimichi Sai
  • Organizer: The Pharmaceutical Society of Korea 2008 Spring International Convention
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2008-05-02
• [Presentation] Trnsporter-mediated approaches for delivery of drugs (2008)
  • Author(s): Yoshimichi Sai
  • Organizer: The Pharmaceutical Society of Korea 2008 Spring International Convention
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2008-05-01
• [Presentation] Uptake mechanism of erythromycin at the blood-placenta barrier. (2008)
  • Author(s): Sai Y, Takagi A, Ochi K, Kose N, Nishimura T, Nakashima E
  • Organizer: 68th FIP World Congress of Pharmacy and Pharmaceutical Sciences(FIP2008)
  • Place of Presentation: Congress Center Basel(Switzerland)
• [Book] 生物薬科学実験講座5、細胞の構造とオルガネラ(細胞膜と膜輸送活性)(大熊勝治/中西義信編) (2010)
  • Author(s): 玉井郁巳、崔吉道
  • Publisher: 廣川書店
• [Book] スタンダード薬学シリーズ6、薬と疾病、IB.薬の効くプロセス(2)薬剤(第2版)、第19章分布(SBO68薬物の胎児への移行について、その機構と血液胎盤関門の意義を説明できる.)(日本薬学会編) (2009)
  • Author(s): 寺崎哲也、崔吉道
  • Publisher: 東京化学同人
• [Remarks] ホームページ等
  • URL: http://web.hosp.kanazawa-u.ac.jp/bu/yaku/
• [Remarks]
  • URL: http://www.p.kanazawa-u.ac.jp/lab/byouin.html
• [Remarks]
  • URL: http://web.hosp.kanazawa-u.ac.jp/bu/yaku/
• [Remarks]
  • URL: http://www.p.kanazawa-u.ac.jp/lab/byouin.html
• [Remarks]
  • URL: http://web.hosp.kanazawa-u.ac.jp/bu/yaku/
• [Remarks]
  • URL: http://www.p.kanazawa-u.ac.jp/lab/byouin.html