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Steroid Withdrawal Based on Lymphocyte Sensitivity to Endogenous Steroid in Renal Transplant Recipients

Research Project

Project/Area Number 20590159
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical pharmacy
Research InstitutionTokyo University of Pharmacy and Life Science

Principal Investigator

TAKEUCHI Hironori  Tokyo University of Pharmacy and Life Science, 薬学部, 准教授 (20439912)

Co-Investigator(Kenkyū-buntansha) HIRANO Toshihiko  東京薬科大学, 薬学部, 教授 (90173252)
Co-Investigator(Renkei-kenkyūsha) NAGAO Takeshi  東京医科大学, 第五外科学講座, 教授 (90143487)
MATSUNO Naoto  東戸塚記念病院, 肝臓病センター長 (00231598)
UNEZAKI Sakae  東京薬科大学, 薬学部, 教授 (00408684)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywordsコルチゾール / リンパ球感受性 / ステロイド離脱 / 腎移植 / メチルプレドニゾロン / バイオマーカー / シクロスポリン / タクロリムス
Research Abstract

We assessed lymphocyte sensitivity to endogenous cortisol and administered steroid as a biomarker for determining the safety of steroid withdrawal in renal transplant patients. Serum creatinine levels increased in a significantly higher number of patients hyposensitive to cortisol and administered steroid than in normally sensitive patients. The patients who have the normal sensitivity of endogenous cortisol and administered steroid, can withdraw steroid more safely. We considered that the highly cortisol-sensitive patients could be sufficiently immunosuppressed by their intrinsic cortisol which will recover after withdrawal of the administrating steroid, and that highly administered steroid -sensitive patients could get to reduce steroid easily. The lymphocyte sensitivity to cortisol and administered steroid may be a useful biomarker for selecting patients who can sustain steroid withdrawal.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (22 results)

All 2011 2010 2009 2008 Other

All Journal Article (5 results) (of which Peer Reviewed: 2 results) Presentation (17 results)

  • [Journal Article] Higher sensitivity of peripheral blood lymphocytes to endogenous glucocorticoid in renal transplant recipients treated with tacrolimus as compared to those treated with cyclosporine2011

    • Author(s)
      Gulimire Muhetaer, Hironori Takeuchi, Sogo Akizuki, Sakae Unezaki, Hitoshi Iwamoto, Motohide Shimazu, Sakae Unezaki
    • Journal Title

      Cell Medicine (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 腎移植患者における内因性コルチゾールのリンパ球感受性に基づくステロイド減量・離脱の可能性2009

    • Author(s)
      竹内裕紀、松野直徒、平野俊彦、畝崎榮、長尾桓
    • Journal Title

      臨床薬理の進歩 30

      Pages: 128-136

    • Related Report
      2010 Final Research Report
  • [Journal Article] 薬剤師による処方支援・28PKおよびPDに基づく腎移植免疫抑制療法の処方支援2008

    • Author(s)
      竹内裕紀、平野俊彦、畝崎榮
    • Journal Title

      医薬ジャーナル 44(5)

      Pages: 1349-1355

    • NAID

      40016057653

    • Related Report
      2010 Final Research Report
  • [Journal Article] PKおよびPDに基づく腎移植免疫抑制療法の処方支援2008

    • Author(s)
      竹内裕紀
    • Journal Title

      医薬ジャーナル 44

      Pages: 1349-1355

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Higher sensitivity of peripheral blood lymphocytes to endogenous glucocorticoid in renal transplant recipients treated with tacrolimus, as compared to those treated with cyclosporine

    • Author(s)
      Gulimire Muhetaer, Hironori Takeuchi, Sogo Akizuki, Sakae Unezaki, Hitoshi Iwamoto, Motohide Shimazu, Toshihiko Hirano
    • Journal Title

      Cell Medicine

      Volume: (accepted)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 腎移植患者のステロイド減量・離脱におけるステロイドのPBMC感受性の有用性2010

    • Author(s)
      竹内裕紀、グリミル ムヒタル、岩本整、中村有紀、濱耕一郎、虎石竜典、平野俊彦、秋月宗剛、川口崇、畝崎榮、島津元秀
    • Organizer
      第37回臓器保存生物医学会学術集会
    • Year and Date
      2010-11-19
    • Related Report
      2010 Final Research Report
  • [Presentation] 腎移植患者のステロイド減量・離脱におけるステロイドのPBMC感受性の有用性2010

    • Author(s)
      竹内裕紀, グリミルムヒタル, 岩本整, 中村有紀, 濱耕一郎, 虎石竜典, 平野俊彦, 秋月宗剛, 川口崇, 畝崎榮, 島津元秀
    • Organizer
      第37回臓器保存生物医学会学術集会
    • Place of Presentation
      新潟
    • Year and Date
      2010-11-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腎移植患者における末梢血リンパ球のコルチゾール感受性に基づく至適免疫抑制の選択2010

    • Author(s)
      グリミル・ムヒタル, 竹内裕紀, 岩本整, 葦沢龍人, 畝崎榮, 平野俊彦, 島津元秀
    • Organizer
      第37回臓器保存生物医学会学術集会
    • Place of Presentation
      新潟
    • Year and Date
      2010-11-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腎移植患者におけるステロイド離脱の指標としての末梢血リンパ球のコルチゾール感受性2010

    • Author(s)
      グリミル・ムヒタル, 岩本整, 葦沢龍人, 竹内裕紀, 畝崎榮, 平野俊彦, 島津元秀
    • Organizer
      第46回日本移植学会
    • Place of Presentation
      新潟
    • Year and Date
      2010-10-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腎移植患者におけるステロイド減量・離脱後の血清クレアチニンの上昇についての検討2010

    • Author(s)
      岩本整, 濱耕一郎, 中村有紀, 今野理, グリミル・ムヒタル, 横山卓剛, 葦澤龍人, 竹内裕紀, 島津元秀
    • Organizer
      第46回日本移植学会
    • Place of Presentation
      新潟
    • Year and Date
      2010-10-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腎移植患者におけるステロイド離脱の指標としての末梢血リンパ球のコルチゾール感受性2010

    • Author(s)
      グリミル ムヒタル、岩本整、葦沢龍人、竹内裕紀、畝崎榮、平野俊彦、島津元秀
    • Organizer
      第46回日本移植学会
    • Year and Date
      2010-10-19
    • Related Report
      2010 Final Research Report
  • [Presentation] Differences of Lymphocyte Sensitivities to Steroids between Patients Administered Tacrolimus and Cyclosporine after Renal Transplantation2010

    • Author(s)
      Hironori Takeuchi, Muhetaer Gulimire, Sougo Akizuki, Koichiro Hama, Yuki Nakamura, Hitoshi Iwamoto, Tatsuto Ashizawa, Tatsunori Toraishi, Sachiko Tanaka, Takashi Kawaguchi, Kiyoshi Okuyama, Takao Akashi, Toshihiko Hirano, Motohide Shimazu, Sakae Unezaki
    • Organizer
      70th International Congress of International Pharmaceutical Federation
    • Place of Presentation
      Lisbon, Portogal
    • Year and Date
      2010-08-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] タクロリムス療法下の腎移植患者における末梢血リンパ球のコルチゾール感受性とその臨床的意義2010

    • Author(s)
      グリミルムヒタル, 岩本整, 葦澤龍人, 島津元秀, 平野俊彦, 秋月綜剛, 竹内裕紀, 畝崎榮
    • Organizer
      第165回東京医科大学医学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-06-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腎移植患者における内因性コルチゾールのリンパ球感受性に基づく早期ステロイド減量・離脱の可能性2010

    • Author(s)
      秋月宗剛、竹内裕紀、平野俊彦、松野直徒、木原優、今野理、城島嘉麿、赤司勲、濱耕一郎、中村有紀、岩本整、葦澤龍人、川口崇、虎石竜典、奥山清、長尾桓、畝崎榮
    • Organizer
      第130回日本薬学会
    • Year and Date
      2010-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 腎移植患者における内因性コルチゾールのリンパ球感受性に基づく早期ステロイド減量・離脱の可能性2010

    • Author(s)
      秋月宗剛, 竹内裕紀, 平野俊彦, 松野直徒, 木原優, 今野理, 城島嘉麿, 赤司勲, 濱耕一郎, 中村有紀, 岩本整, 葦澤龍人, 川口崇, 虎石竜典, 奥山清, 長尾桓, 畝崎榮
    • Organizer
      第130回日本薬学会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] タクロリムス療法下の腎移植患者における末梢血リンパ球のコルチゾール感受性とその臨床的意義2010

    • Author(s)
      グリミルムヒタル、秋月綜剛、竹内裕紀、畝崎榮、松野直徒、長尾桓、平野俊彦
    • Organizer
      第130回日本薬学会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 腎移植におけるステロイド減量、離脱のためのCOR IC50の有用性2009

    • Author(s)
      松野直徒, 竹内裕紀, 平野俊彦, 浦島良典, 川瀬友則, 寺岡慧
    • Organizer
      第45回日本移植学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 腎移植におけるステロイド減量、離脱のためのCOR IC50の有用性2009

    • Author(s)
      松野直徒、竹内裕紀、平野俊彦、浦島良典、川瀬友則、寺岡慧
    • Organizer
      第45回日本移植学会総会
    • Year and Date
      2009-09-17
    • Related Report
      2010 Final Research Report
  • [Presentation] 腎移植患者がステロイドを安全に減量・離脱するための薬力学的指標の検討の開発-2009

    • Author(s)
      谷口雅彦
    • Organizer
      第129回日本薬学会
    • Place of Presentation
      京都府
    • Year and Date
      2009-03-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] 腎移植の薬物療法管理-ステロイドを安全に減量する検査方法の開発-2008

    • Author(s)
      谷口雅彦
    • Organizer
      八王子市産学公連携機構第8回研究成果発表講演会
    • Place of Presentation
      東京都
    • Year and Date
      2008-12-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] possibi1ity of steroid withdrawal based on lymphocyte sensitivity of endogenous cortisol in renal transplant recipients2008

    • Author(s)
      Hironori Takeuchi
    • Organizer
      68th International Congress of lnternational Pharmaceutical Federation
    • Place of Presentation
      Basel Switzerland
    • Year and Date
      2008-08-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] possibility of steroid withdrawal based on lymphocyte sensitivity of endogenous cortisol in renal transplant recipients2008

    • Author(s)
      Hironori Takeuchi, Naoto Matsuno, Toshihiko Hirano, Abuduxukuer Mijiti, Takeshi Nagao, Tatsunori Toraishi, Kiyoshi Okuyama, Takao Akashi, Sakae Unezaki
    • Organizer
      68th International Congress of lnternational Pharmaceutical Federation
    • Year and Date
      2008-08-30
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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