Steroid Withdrawal Based on Lymphocyte Sensitivity to Endogenous Steroid in Renal Transplant Recipients
Project/Area Number |
20590159
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Medical pharmacy
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Research Institution | Tokyo University of Pharmacy and Life Science |
Principal Investigator |
TAKEUCHI Hironori Tokyo University of Pharmacy and Life Science, 薬学部, 准教授 (20439912)
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Co-Investigator(Kenkyū-buntansha) |
HIRANO Toshihiko 東京薬科大学, 薬学部, 教授 (90173252)
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Co-Investigator(Renkei-kenkyūsha) |
NAGAO Takeshi 東京医科大学, 第五外科学講座, 教授 (90143487)
MATSUNO Naoto 東戸塚記念病院, 肝臓病センター長 (00231598)
UNEZAKI Sakae 東京薬科大学, 薬学部, 教授 (00408684)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
|
Keywords | コルチゾール / リンパ球感受性 / ステロイド離脱 / 腎移植 / メチルプレドニゾロン / バイオマーカー / シクロスポリン / タクロリムス |
Research Abstract |
We assessed lymphocyte sensitivity to endogenous cortisol and administered steroid as a biomarker for determining the safety of steroid withdrawal in renal transplant patients. Serum creatinine levels increased in a significantly higher number of patients hyposensitive to cortisol and administered steroid than in normally sensitive patients. The patients who have the normal sensitivity of endogenous cortisol and administered steroid, can withdraw steroid more safely. We considered that the highly cortisol-sensitive patients could be sufficiently immunosuppressed by their intrinsic cortisol which will recover after withdrawal of the administrating steroid, and that highly administered steroid -sensitive patients could get to reduce steroid easily. The lymphocyte sensitivity to cortisol and administered steroid may be a useful biomarker for selecting patients who can sustain steroid withdrawal.
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Report
(4 results)
Research Products
(22 results)
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[Presentation] 腎移植患者のステロイド減量・離脱におけるステロイドのPBMC感受性の有用性2010
Author(s)
竹内裕紀, グリミルムヒタル, 岩本整, 中村有紀, 濱耕一郎, 虎石竜典, 平野俊彦, 秋月宗剛, 川口崇, 畝崎榮, 島津元秀
Organizer
第37回臓器保存生物医学会学術集会
Place of Presentation
新潟
Year and Date
2010-11-19
Related Report
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[Presentation] Differences of Lymphocyte Sensitivities to Steroids between Patients Administered Tacrolimus and Cyclosporine after Renal Transplantation2010
Author(s)
Hironori Takeuchi, Muhetaer Gulimire, Sougo Akizuki, Koichiro Hama, Yuki Nakamura, Hitoshi Iwamoto, Tatsuto Ashizawa, Tatsunori Toraishi, Sachiko Tanaka, Takashi Kawaguchi, Kiyoshi Okuyama, Takao Akashi, Toshihiko Hirano, Motohide Shimazu, Sakae Unezaki
Organizer
70th International Congress of International Pharmaceutical Federation
Place of Presentation
Lisbon, Portogal
Year and Date
2010-08-29
Related Report
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[Presentation] 腎移植患者における内因性コルチゾールのリンパ球感受性に基づく早期ステロイド減量・離脱の可能性2010
Author(s)
秋月宗剛, 竹内裕紀, 平野俊彦, 松野直徒, 木原優, 今野理, 城島嘉麿, 赤司勲, 濱耕一郎, 中村有紀, 岩本整, 葦澤龍人, 川口崇, 虎石竜典, 奥山清, 長尾桓, 畝崎榮
Organizer
第130回日本薬学会
Place of Presentation
岡山
Year and Date
2010-03-28
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