Fatty acid metabolism of diabetic cardiomyopathy and failing heart

• Project/Area Number: 20590161
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Nigata University of Phermacy and Applied Life Sciences
• Principal Investigator: WATANABE Kenichi Nigata University of Phermacy and Applied Life Sciences, 薬学部, 教授 (70175090)
• Co-Investigator(Renkei-kenkyūsha): MA Meirei 新潟薬科大学, 薬学部, 助手 (20333536)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 医療薬剤学 / 標識脂肪酸 / 糖尿病 / 心不全 / 心筋代謝 / アイソトープ

Research Abstract

(No Summary)

Research Products

• [Journal Article] Carvedilol-afforded protection against daunorubicin-induced cardiomyopathic rats in vivo : effects on cardiac fibrosis andhypertrophy. (2011)
  • Author(s): Wawaimuli A, K Watanabe, et al
  • Journal Title: ISRN Pharmacology. (in press)
• [Journal Article] Curcumin ameliorates cardiac inflammation in rats with autoimmune myocarditis. (2011)
  • Author(s): S Mito, K Watanabe, et al
  • Journal Title: Biol.Pharm.Bull. (in press)
  • NAID: 130000738083
• [Journal Article] Carvedilol attenuates inflammatory-mediated cardiotoxicity in daunorubicin-induced rats. (2011)
  • Author(s): Flori R.S, K Watanabe, et al., M Harima
  • Journal Title: Pharmaceuticals. 4 Pages: 551-566
• [Journal Article] Role of 14-3-3 protein mediated nuclear factor-kB signaling in cardiac oxidative stress, inflammation and remodeling after streptozotocin-induced diabetes mellitus. (2011)
  • Author(s): Rajarajan AT, K Watanabe, et al
  • Journal Title: Free Radical Research. (in press)
• [Journal Article] Olmesartan, an AT1 antagonist, attenuates oxidative stress, endoplasmic reticulum stress and cardiac inflammatory mediators in rats with heart failure induced by experimental autoimmune myocarditis. (2011)
  • Author(s): Vijayakumar S, K Watanabe, et al
  • Journal Title: International Journal of Biological Sciences. 7 Pages: 154-167
• [Journal Article] Telmisartan prevents the progression of renal injury in daunorubicin rats with the alteration of angiotensin II and endothelin-1 receptor expression associated with its PPAR γ agonist actions. (2011)
  • Author(s): Wawaimuli A, K Watanabe, et al
  • Journal Title: Toxicology. 279 Pages: 91-99
• [Journal Article] Analysis of intestinal fibrosis in chronic colitis in mice induced by dextran sulfate sodium. (2011)
  • Author(s): Suzuki K, Watanabe K, et al
  • Journal Title: Pathology International. (in press)
  • NAID: 10031185076
• [Journal Article] Telmisartan attenuates oxidative stress and renal fibrosis in streptozotocin induced diabetic mice with the alteration of angiotensin-(1-7) mas receptor expression associated with its PPAR-gamma agonist action. (2011)
  • Author(s): Lakshmanan AP, Watanabe K, et al
  • Journal Title: Free Radical Research. (in press)
• [Journal Article] Analysis of intestinal fibrosis in chronic colitis in mice induced by dextran sulfate sodium. (2011)
  • Author(s): Suzuki K, Watanabe K, et al
  • Journal Title: Pathology International. 10 Pages: 1440-1450
  • NAID: 10031185076
• [Journal Article] Telmisartan ameliorates experimental autoimmune myocarditis associated with inhibition of inflammation and oxidative stress. (2011)
  • Author(s): Vijayakumar S, K Watanabe, et al
  • Journal Title: European Journal of Pharmacology. 652 Pages: 126-135
• [Journal Article] Beneficial effects of olmesartan, an angiotensin II receptor type 1 antagonist, in rats with dilated cardiomyopathy. (2011)
  • Author(s): Vijayakumar S, K Watanabe, et al
  • Journal Title: Experi Biol Med. (in press)
• [Journal Article] Telmisartan, an angiotensin-II receptor blocker ameliorate cardiac remodeling in rats with dilated cardiomiopathy (2011)
  • Author(s): Vijayakumar S, Watanabe K, et al
  • Journal Title: Hypertension Res. (in press)
• [Journal Article] A novel phenylpyridazinone, T-3999, reduces the progression of autoimmune myocarditis to dilated cardiomyopathy. (2011)
  • Author(s): Fadia AK, Watanabe K, et al
  • Journal Title: Heart and Vessels. (in press)
• [Journal Article] Modulation of doxorubicin-induced cardiac dysfunction in dominant negative p38<alpha> mitogen-activated protein kinase mice. (2010)
  • Author(s): Rajarajan A, T, K Watanabe, et al
  • Journal Title: Free Radical Biology and Medicine. 49 Pages: 1422-1431
• [Journal Article] Role of Differential Signaling Pathways and Oxidative Stress in Diabetic Cardiomyopathy. (2010)
  • Author(s): K Watanabe, et al
  • Journal Title: Current Cardiology Reviews. 6 Pages: 280-290
• [Journal Article] 14-3-3 Protein Protects Against Cardiac Endoplasmic Reticulum Stress (ERS) and ERS-Initiated Apoptosis in Experimental Diabetes. (2010)
  • Author(s): Flori R Sari, Watanabe K, et al
  • Journal Title: J Pharmacol Sci. 113 Pages: 325-334
  • NAID: 10027745962
• [Journal Article] Arginine vasopressin receptor antagonists 'vaptans' : pharmacological tools and potential therapeutic agents. (2010)
  • Author(s): Punniyakoti T V, K Watanabe, et al
  • Journal Title: Drug Discovery Today. 15 Pages: 826-841
• [Journal Article] Partial inactivation of cardiac 14-3-3 protein in vivo elicits endoplasmic reticulum stress (ERS) and activated ERS-initiated apoptosis in ERS-induced mice. (2010)
  • Author(s): Flori R Sari, Watanabe K, et al
  • Journal Title: Cell Physiol Biochem. 26 Pages: 167-178
• [Journal Article] The antioxidant edaravone attenuates ER-stress-mediated cardiac apoptosis and dysfunction in rats with autoimmune myocarditis. (2010)
  • Author(s): Shimazaki H, Watanabe K, et al
  • Journal Title: Free Radical Research. 44 Pages: 1082-1090
• [Journal Article] Protective effect of carvedilol on daunorubicin-induced cardiotoxicity and nephrotoxicity in rats. (2010)
  • Author(s): Wawaimuli A, K Watanabe, et al
  • Journal Title: Toxicology. 274 Pages: 18-26
• [Journal Article] Rectal administration of tranilast ameliorated acute colitis in mice through increased expression of heme oxygenase-1. (2010)
  • Author(s): Sun X, Watanabe K, et al
  • Journal Title: J Pathology. 60 Pages: 93-101
• [Journal Article] Benefi cial effects of angiotensin II receptor blocker, olmesartan, in limiting the cardiotoxic effect of daunorubicin in rats. (2010)
  • Author(s): Wawaimuli A, K WATANABE, et al
  • Journal Title: Free Radical Research (Early Online) Pages: 1-9
• [Journal Article] Modulation of doxorubicin-induced cardiac dysfunction in dominant negative p38<alpha> mitogen-activated protein kinase mice. (2010)
  • Author(s): Rajarajan A, T, K Watanabe, et al.
  • Journal Title: Free Radical Biology and Medicine. Volume: 49 Pages: 1422-1431
  • Peer Reviewed
• [Journal Article] Role of Differential Signaling Pathways and Oxidative Stress in Diabetic Cardiomyopathy. (2010)
  • Author(s): K Watanabe, et al.
  • Journal Title: Current Cardiology Reviews. Volume: 6 Pages: 280-290
  • Peer Reviewed
• [Journal Article] Arginine vasopressin receptor antagonists 'vaptans' : pharmacological tools and potential therapeutic agents. (2010)
  • Author(s): Punniyakoti T V, K Watanabe, et al.
  • Journal Title: Drug Discovery Today Volume: 15 Pages: 826-841
  • Peer Reviewed
• [Journal Article] Rectal administration of tranilast ameliorated acute colitis in mice through increased expression of heme oxygenase-1. (2010)
  • Author(s): Sun X, Watanabe K, et al.
  • Journal Title: J Pathology. 60 Pages: 93-101
  • Peer Reviewed
• [Journal Article] Role of 14-3-3 protein and oxidative stress in diabetic cardiomyopathy. (2009)
  • Author(s): Watanabe K, et al
  • Journal Title: Acta Physiologica Hungarica. 96 Pages: 277-287
• [Journal Article] LDL Cholesterol is More Strongly Associated with Metabolic Syndrome in Japanese Women than in Men. (2009)
  • Author(s): Eiji Oda, K Watanabe, et al
  • Journal Title: Inter Med. 48 Pages: 1607-1614
  • NAID: 130000122071
• [Journal Article] Dominant-negative p38α mitogen-activated protein kinase prevents cardiac apoptosis and remodeling after streptozotocin-induced diabetes mellitus. (2009)
  • Author(s): Rajarajan A, T, K Watanabe, et al
  • Journal Title: Am J Physiol Heart Circ Physiol. 297
• [Journal Article] Prevalence of Metabolic Syndrome Increases with the Increase in Blood Levels of Gamma Glutamyltransferase and Alanine Aminotransferase in Japanese Men and Women. (2009)
  • Author(s): E Oda, K Watanabe, et al
  • Journal Title: Inter Med. 48 Pages: 1343-1350
  • NAID: 130000122012
• [Journal Article] Effects of angiotensin receptor blocker on oxidative stress and cardio-renal function in streptozotosin-induced diabetic rats. (2009)
  • Author(s): Wawaimuli A, K Watanabe, et al
  • Journal Title: Biol Pharm Bull. 32 Pages: 1411-1416
• [Journal Article] Long-term Carperitide Treatment Attenuates Left Ventricular Remodelingin Rats with Heart Failure after Autoimmune Myocarditis. (2009)
  • Author(s): K Tanaka, K Watanabe, et al
  • Journal Title: J Cardiovascul Pharmacol. 54 Pages: 232-239
• [Journal Article] The effects of r-aminobutyric acid, vinegar, and dried bonito on blood pressure in normotensive and mildly or moderately hypertensive volunteers. (2009)
  • Author(s): H Tanaka, K Watanabe, et al
  • Journal Title: J Clin Biochem Nutr. 45 Pages: 93-100
• [Journal Article] Beneficial Effect of Food Substitute Containing L-arginine, &Omega3-poly Unsaturated Fatty Acid, and Ribonucleic Acid in Preventing or Improving Metabolic Syndrome : A Study in 15 Overweight Patients and a Study of Fatty Acid Metabolism in Animals. (2009)
  • Author(s): K Watanabe, et al
  • Journal Title: J Clin Biochem Nutr. 44 Pages: 266-274
  • NAID: 130004466550
• [Journal Article] Role of 14-3-3 protein and oxidative stress in diabetic cardiomyopathy. (2009)
  • Author(s): Watanabe K, et al.
  • Journal Title: Acta Physiologica Hungarica 96 Pages: 277-287
  • Peer Reviewed
• [Journal Article] LDL Cholesterol is More Strongly Associated with Metabolic Syndrome in Japanese Women Than in Men. (2009)
  • Author(s): Eiji Oda, K Watanabe., et al.
  • Journal Title: Inter Med. 48 Pages: 1607-1614
  • NAID: 130000122071
  • Peer Reviewed
• [Journal Article] Dominant-negative p38α mitogen-activated protein kinase prevents cardiac apoptosis and remodeling after streptozotocin-induced diabetes mellitus. (2009)
  • Author(s): Rajarajan A, T, K Watanabe, et al.
  • Journal Title: Am J Physiol Heart Circ Physiol. 297
  • Peer Reviewed
• [Journal Article] Prevalence of Metabolic Syndrome Increases with the Increase in Blood Levels of Gamma Glutamyltransferase and Alanine Aminotransferase in Japanese Men and Women. (2009)
  • Author(s): Eiji Oda, K Watanabe., et al.
  • Journal Title: Inter Med. 48 Pages: 1343-1350
  • NAID: 130000122012
  • Peer Reviewed
• [Journal Article] Effects of angiotensin receptor blocker on oxidative stress and cardio-renal function in streptozotosin-induced diabetic rats. (2009)
  • Author(s): Wawaimuli A, K Watanabe, et al.
  • Journal Title: Biol Pharm Bull. 32 Pages: 1411-1416
  • Peer Reviewed
• [Journal Article] Long-term Carperitide Treatment Attenuates Left Ventricular Remodelingin Rats with Heart Failure after Autoimmune Myocarditis. (2009)
  • Author(s): Tanaka K, Watanabe K, et al.
  • Journal Title: J Cardiovascul Pharmacol. 54 Pages: 232-239
  • Peer Reviewed
• [Journal Article] The effects of r-aminobutyric acid, vinegar, and dried bonito on blood pressure in normotensive and mildly or moderately hypertensive volunteers. (2009)
  • Author(s): H Tanaka, K Watanabe, et al.
  • Journal Title: J Clin Biochem Nutr. 45 Pages: 93-100
  • Peer Reviewed
• [Journal Article] 14-3-3 protein regulates Askl signaling and protects against diabetic cardiomyopathy. (2008)
  • Author(s): Rajarajan A, Watanabe K, 他
  • Journal Title: Biochem. Pharmacol 75 Pages: 1797-1806
  • Peer Reviewed
• [Journal Article] Effects of V2-receptor antagonist tolvaptan and the loop diuretic furosemide in rats with heart failure. (2008)
  • Author(s): Punnivakoti T V, Watanabe K, 他
  • Journal Title: Biochem. Pharmacol. 75 Pages: 1322-1330
  • Peer Reviewed
• [Journal Article] Torasemide, a long-acting loop diuretic, reduces the progression of myocarditis to dilated cardiomyopathy. (2008)
  • Author(s): Punniyakoti T V, Watanabe K, 他
  • Journal Title: Eur J Pharmacol 281 Pages: 121-131
  • Peer Reviewed
• [Presentation] Beneficial effects of telmisartan, an angiotensin-II type 1 receptor antagonist in mice with streptozotocin induced diabetic nephropathy. (2011)
  • Author(s): Arun P, Watanabe K, et al.
  • Organizer: International Conference on Recent Trends in TA of Free Radical Science
  • Place of Presentation: Chennai, INDIA
  • Year and Date: 2011-01-10
• [Presentation] Effects of Losartan on oxidative status and cardiac and renal function in streptozotocin-insuced diabetic rats. (2009)
  • Author(s): Wawaimuli A, K Watanabe, et al.
  • Organizer: The Congress of the European Association for Clinical Pharmacology and Therapeutics
  • Place of Presentation: エジンバラ、UK.
  • Year and Date: 2009-07-14
• [Book] Advances in Medicine and Biology. Volume 29. Chapter VIII. Aldosterone antagonist and diuretics for heart hailure (2011)
  • Author(s): Watanabe K, et al.
  • Total Pages: 20
  • Publisher: Nova Science Publishers Inc.
• [Patent(Industrial Property Rights)] アトピー性皮膚炎の治療に有効なまいたけ抽出物もしくは抽出画分 (2009)
  • Inventor(s): 渡辺賢一、田中昭弘、川面香奈
  • Industrial Property Rights Holder: 株式会社雪国まいたけ
  • Industrial Property Number: 2009-214649
  • Filing Date: 2009-09-16