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Development of a new evaluation system for generic drugs using taste sensors

Research Project

Project/Area Number 20590166
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical pharmacy
Research InstitutionMukogawa Women's University

Principal Investigator

UCHIDA Takahiro  Mukogawa Women's University, 薬学部, 教授 (70203536)

Co-Investigator(Renkei-kenkyūsha) YOSHIDA Miyako  武庫川女子大学, 薬学部, 講師 (20369028)
HAZEKAWA Mai  武庫川女子大学, 薬学部, 助手 (10509186)
HARAGUCHI Tamami  武庫川女子大学, 薬学部, 助手 (10550741)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2008: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Keywords苦味強度 / 薬物溶出 / 味覚センサ / 主成分分析 / 官能試験 / 崩壊性 / 口腔内 / 苦味予測法 / 溶出試験 / 崩壊時間 / 服用性 / SD法 / 後発品 / 薬学 / 臨床 / 解析・評価 / 味センサ / 服用感 / ファモチジン
Research Abstract

We evaluated the bitterness of dry syrup or orally-disintegrating tablet. Bitterness intensity and dissolved Clarithromycin concentration were well correlated. In the study of Famotidine orally-disintegrating tablet, there was a good correlation between the taste predicted by principal component analysis and the Euclidean distance obtained by the taste sensor, and bitterness intensities obtained in the human gustatory tests. Finally, we evaluated the comprehensive behavior of drugs using a new disintegration testing apparatus in addition to gustatory test and dissolution test.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (38 results)

All 2011 2010 2009 Other

All Journal Article (18 results) (of which Peer Reviewed: 17 results) Presentation (18 results) Remarks (2 results)

  • [Journal Article] Influence of swallowing aids on the adsorption and palatability of Kremezin^[○!R]2011

    • Author(s)
      M.Yoshida, T.Uchida, et al.
    • Journal Title

      Chem.Pharm.Bull. 59(4)

      Pages: 434-437

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synergic effects of sour taste and low temperature in suppressing the bitterness of Aminoleban ^[○!R]EN.2011

    • Author(s)
      T.Haraguchi, T.Uchida, et al.
    • Journal Title

      Chem.Pharm.Bull. 59(5)

      Pages: 536-540

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bitterness suppression of Kampo medicine Orengedokuto using flavored fellies.2011

    • Author(s)
      M.Yoshida, T.Uchida, et al.
    • Journal Title

      Chem.Pharm.Bull. 58(4)

      Pages: 449-453

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of Swallowing Aids on the Adsorption and Palatability of Kremezin^[○!R]2011

    • Author(s)
      M.Yoshida, T.Uchida, et al
    • Journal Title

      Chem.Pharm.Bull

      Volume: 59(4) Pages: 434-437

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic Effects of Sour Taste and Low Temperature in Suppressing the Bitterness of Aminoleban^[○!R] EN2011

    • Author(s)
      T.Haraguchi, T.Uchida, et al
    • Journal Title

      Chem.Pharm.Bull

      Volume: 59(5) Pages: 536-540

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bitterness suppression of the Kampo medicine 'Orengedokuto' using flavored jellies2011

    • Author(s)
      M.Yoshida, T.Uchida, et al
    • Journal Title

      Chem.Pharm.Bull

      Volume: 58(4) Pages: 449-453

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new method for evaluating the bitterness of medicines in development using a taste sensor and disintegration testing apparatus.2010

    • Author(s)
      T.Harada, T.Uchida, et al.
    • Journal Title

      Chem.Pharm.Bull. 58(8)

      Pages: 1009-1014

    • NAID

      130000299806

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of physical properties of orally disintegration tablets on disintegration times as determined by a new apparatus.2010

    • Author(s)
      T.Harada, T.Uchida, et al.
    • Journal Title

      J.DRUG DEL.SCI.TECH. 20(5)

      Pages: 377-383

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] クラリスロマイシンドライシロップ製剤の酸性スポーツ飲料併用時およびムコダイン^[○!R]DS併用時の苦味予測2010

    • Author(s)
      櫨川舞、内田享弘, 他
    • Journal Title

      医療薬学 36(4)

      Pages: 262-269

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A new method for evaluating the bitterness of medicines in development using a taste sensor and disintegration testing apparatus2010

    • Author(s)
      T.Harada, T.Uchida, et al
    • Journal Title

      Chem.Pharm.Bull

      Volume: 58(8) Pages: 1009-1014

    • NAID

      130000299806

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of physical properties of orally disintegration tablets on disintegration times as determined by a new apparatus2010

    • Author(s)
      T.Harada, T.Uchida, et al
    • Journal Title

      J.DRUG DEL.SCI.TECH.

      Volume: 20(5) Pages: 377-383

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] クラリスロマイシンドライシロップ製剤の酸性スポーツ飲料併用時およびムコダイン^[○!R]DS併用時の苦味予測2010

    • Author(s)
      櫨川舞、内田享弘, 他
    • Journal Title

      医療薬学

      Volume: 36(4) Pages: 262-269

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] クラリスロマイシンドライシロップ製剤の酸性スポーツ飲料併用時およびムコダイン(R)DS併用時の苦味予測2010

    • Author(s)
      櫨川舞, 他
    • Journal Title

      医療薬学 36(4)

      Pages: 262-269

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Famotidine orally disintegrating tablets : Bitterness comparison of original and generic products.2009

    • Author(s)
      E.Tokuyama, T.Uchida, et al.
    • Journal Title

      Chem.Pharm.Bull. 57(4)

      Pages: 382-387

    • NAID

      110007160639

    • Related Report
      2010 Final Research Report
  • [Journal Article] 新しいアムロジン^[○!R]OD錠(SUITAB-NEX^[○!R]/アムロジピン口腔内崩壊錠)の服用性の定量評価2009

    • Author(s)
      内田享弘, 他
    • Journal Title

      新薬と臨牀 58(5)

      Pages: 854-862

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Famotidine orally disintegrating tablets : Bitterness comparison of original and generic products2009

    • Author(s)
      E.Tokuyama, et al
    • Journal Title

      Chem.Pharm. Bull 57(4)

      Pages: 382-387

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新しいアムロジン(R)OD錠(SUITAB-NEX(R)/アムロジピン口腔内崩壊錠)の服用性の定量評価2009

    • Author(s)
      内田享弘, 他
    • Journal Title

      新薬と臨牀 58(5)

      Pages: 854-862

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Famotidine Orally Disintegrating Tablets : Bitterness Comparison of Original and Generic Products2009

    • Author(s)
      Tokuyama, et al
    • Journal Title

      Chemical & Pharmaceutical Bulletin 57(4)

      Pages: 382-387

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 味覚センサを用いたアムロジピンOD錠10製剤の苦味予測2010

    • Author(s)
      内田享弘
    • Organizer
      日本医療薬学会年会
    • Place of Presentation
      千葉
    • Year and Date
      2010-11-13
    • Related Report
      2010 Final Research Report
  • [Presentation] 味覚センサを用いたアムロジピンOD錠10製剤の苦味予測2010

    • Author(s)
      内田享弘
    • Organizer
      日本医療薬学会年会
    • Place of Presentation
      千葉 幕張メッセ
    • Year and Date
      2010-11-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] クレメジン^[○!R]細粒の吸着性と服用性に関する検討2010

    • Author(s)
      吉田都
    • Organizer
      第60回日本薬学会近畿支部大会・総会
    • Place of Presentation
      摂南大学
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] アムロジピンOD錠の苦味評価-崩壊性および溶出性について-2010

    • Author(s)
      櫨川舞
    • Organizer
      日本薬剤学会第25年会
    • Place of Presentation
      徳島
    • Year and Date
      2010-05-12
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 経口製剤に見るLCMとその利点2010

    • Author(s)
      内田享弘
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-30
    • Related Report
      2010 Final Research Report
  • [Presentation] 経口製剤に見るLCMとその利点2010

    • Author(s)
      内田享弘
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2010-03-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] クラリスロマイシンドライシロップ製剤の酸性スポーツ飲料併用時及びムコダイン[○!R]DS2009

    • Author(s)
      杉野友香、内田享弘
    • Organizer
      併用時の苦味予測 第3回次世代を担う若手医療薬科学
    • Place of Presentation
      福岡(シンポジウム)
    • Year and Date
      2009-11-14
    • Related Report
      2010 Final Research Report
  • [Presentation] クラリスロマイシンドライシロップ製剤の酸性スポーツ飲料併用時及びムコダイン(R)DS併用時の苦味予測2009

    • Author(s)
      杉野友香
    • Organizer
      第3回次世代を担う若手医療薬科学シンポジウム
    • Place of Presentation
      九州大学
    • Year and Date
      2009-11-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] クレメジン^[○!R]細粒の吸着性と服用性におよぼす市販嚥下補助ゼリーの影響2009

    • Author(s)
      内田享弘
    • Organizer
      第19回日本医療薬学会年会
    • Place of Presentation
      長崎
    • Year and Date
      2009-10-24
    • Related Report
      2010 Final Research Report
  • [Presentation] クラリスロマイシンDSの粒度別評価2009

    • Author(s)
      櫨川舞
    • Organizer
      第19回日本医療薬学会年会
    • Place of Presentation
      長崎
    • Year and Date
      2009-10-24
    • Related Report
      2010 Final Research Report
  • [Presentation] アンブロキソール錠10製剤の苦味評価:温度の影響2009

    • Author(s)
      杉野友香、内田享弘
    • Organizer
      第19 回日本医療薬学会年会
    • Place of Presentation
      長崎
    • Year and Date
      2009-10-24
    • Related Report
      2010 Final Research Report
  • [Presentation] クレメジン(R)細粒の吸着性と服用性におよぼす市販嚥下補助ゼリーの影響2009

    • Author(s)
      内田享弘
    • Organizer
      第19回日本医療薬学会年会
    • Place of Presentation
      長崎大学
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] アンブロキソール錠10製剤の苦味評価:温度の影響2009

    • Author(s)
      杉野友香
    • Organizer
      第19回日本医療薬学会年会
    • Place of Presentation
      長崎大学
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] クラリスロマイシンDSの粒度別評価2009

    • Author(s)
      櫨川舞
    • Organizer
      第19回日本医療薬学会年会
    • Place of Presentation
      長崎大学
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 製剤学的見地から医薬品を考える2009

    • Author(s)
      内田享弘
    • Organizer
      第12回日本医薬品情報学会総会・学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2009-07-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 製剤学的見地から医薬品を考える2009

    • Author(s)
      内田享弘
    • Organizer
      第12回日本医薬品情報学会総会・学術大会
    • Place of Presentation
      九州大学医学部百年講堂
    • Year and Date
      2009-07-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] アムロジピン口腔内崩壊錠の服用性の評価2009

    • Author(s)
      内田享弘
    • Organizer
      日本薬剤学会第24年会
    • Place of Presentation
      静岡
    • Year and Date
      2009-05-21
    • Related Report
      2010 Final Research Report
  • [Presentation] アムロジピン口腔内崩壊錠の服用性の評価2009

    • Author(s)
      内田享弘
    • Organizer
      日本薬剤学会第24年会
    • Place of Presentation
      静岡県コンベンションアーツセンター
    • Year and Date
      2009-05-21
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://ph.mukogawa-u.ac.jp/~rseizai/index.html

    • Related Report
      2010 Final Research Report
  • [Remarks] 臨床製剤学研究室ホームページ

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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