Fc receptor-related biological properties of anti-TNF therapeutics
| Project/Area Number |
20590167
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
ISHII Akiko National Institute of Health Sciences, 生物薬品部, 第二室長 (50291117)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Takuo 国立医薬品食品衛生研究所, 生物薬品部・第2室, 主任研究官 (10415466)
TADA Minoru 国立医薬品食品衛生研究所, 生物薬品部・第2室, 研究員 (50506954)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 抗体医薬品 / Fc融合タンパク質医薬品 / Fc受容体 / FcRn / FcγR / TNF / 血中半減期 / バイオ医薬品 / 体内動態 / FcRn(neonatal Fc receptor) / 半減期 |
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| Research Abstract |
In order to elucidate the differences in the biological activities of anti-TNF therapeutics, their interactions with Fc receptors were examined. TNFR-Fc fusion protein showed lower affinity to FcRn than the anti-TNF antibodies did. Apparent molecular size of the complexes composed of TNF and anti-TNF antibodies differed in each antibody, and the activation of FcγR was dependent on the complex size. These characteristics were thought to be responsible for the differences in their serum half-life regulated by FcRn, and the incidence of infusion reaction or anti-drug antibody, which is related to the activation of FcγR on immune effector cells.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Genetic polymorphisms of FCGRT encoding FcRn in a Japanese population and their functional analysis.2010
Author(s)
Ishii-Watabe A, Saito Y, Suzuki T, Tada M, Ukaji M, Maekawa K, Kurose K, Kaniwa N, Sawada J, Kawasaki N, Yamaguchi T, Nakajima TE, Kato K, Yamada Y, Shimada Y, Yoshida T, Ura T, Saito M, Muro K, Doi T, Fuse N, Yoshino T, Ohtsu A, Saijo N, Hamaguchi T, Okuda H, Matsumura Y
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Journal Title
Drug Metab.Pharmacokinet. 25(6)
Pages: 578-587
NAID
Related Report
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[Journal Article] Genetic polymorphisms of FCGRT encoding FcRn in a Japanese population and their functional analysis.2010
Author(s)
Akiko Ishii-Watabe, Yoshiro Saito, Takuo Suzuki, Minoru Tada, Maho Ukaji, Keiko Maekawa, Kouichi Kurose, Nahoko Kaniwa, Jun-ichi Sawada, Nana Kawasaki, Teruhide Yamaguchi, Takako Eguchi Nakajima, Ken Kato, Yasuhide Yamada, Yasuhiro Shimada, Teruhiko Yoshida, Takashi Ura, Miyuki Saito, Kei Muro, Toshihiko Doi, Nozomu Fuse, Takayuki Yoshino, Atsushi Ohtsu, Nagahiro Saijo, Tetsuya Hamaguchi , Haruhiro Okuda, Yasuhiro Matsumura
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Journal Title
Drug Metab.Pharmacokinet.
Volume: 25(6)
Pages: 578-587
NAID
Related Report
Peer Reviewed
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