Fish as a new model animal for the molecular genetic study on lymphangiogenesis
| Project/Area Number |
20590175
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Iwate Medical University |
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Principal Investigator |
ISOGAI Sumio Iwate Medical University, 医学部, 准教授 (60212966)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 発生学・形態形成学 / 発生生物学 / リンパ管 / 魚類 / モデル動物 / リンパ管新生 / 解剖学 / 細胞 / 発生・分化 / 小型魚類 / リンパ管発生 / ゼブラフィッシュ / メダカ / 解剖アトラス / トランスジェニック / バイオイメージング / リンパ管造影 |
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| Research Abstract |
Since 2004, we have worked to make the zebrafish a new genetic model to unravel the function of candidate gene involved in lymphangiogenesis. As the first step, we have compiled the developing anatomical atlas of the lymphatic vascular system from the embryo through the adult. We established EGFP transgenic lines whose have lethal defects on the formation of lymphatic vascular system, and revealed the cause of defects morphologically using 2-photon laser microscope. Based on the observations, Weinstein's lab of NIH showed that chemokine signaling provides a crucial guidance cue directing early lymphatic vascular formation (submitted).
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Report
(4 results)
Research Products
(36 results)
