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Developments of cerebral sulci and gyri in cynomolgus monkey fetuses : a quantitative analysis using 7 tesla MRI

Research Project

Project/Area Number 20590176
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General anatomy (including Histology/Embryology)
Research InstitutionTsukuba International University

Principal Investigator

澤田 和彦  Tsukuba International University, 医療保健学部, 教授 (10284324)

Co-Investigator(Kenkyū-buntansha) 坂田 ひろみ  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (50294666)
孫 学智  独立行政法人放射線医学総合研究所, 放射線防護研究センター, 主任研究員 (00284323)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsサル / 大脳 / 脳溝 / 脳回 / MRI胎 / 仔 / 霊長類 / 系統発生 / MRI / 胎仔
Research Abstract

T1-weighted MRI images were acquired from formalin-fixed cerebra of cynomolgus monkey fetuses on embryonic days (EDs) 70 to 150 using a high spatial resolution 7-tesla MR system. The results clarified MRI-based chronology of the emergences of cerebral sulci and gyri in this primate. Quantitative analysis revealed a correlation of the emergence of the primary sulci with the development of subcortical white matter bundles. Furthermore, diffusion tensor imaging revealed a spatiotemporal relation of each primary sulci with the specific cortico-cortical long associative fibers.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (24 results)

All 2010 2009 2008 Other

All Journal Article (7 results) (of which Peer Reviewed: 6 results) Presentation (16 results) Remarks (1 results)

  • [Journal Article] Ontogenetic pattern of gyrification in fetuses of cynomolgus monkeys.2010

    • Author(s)
      Sawada K, Sun X-Z, Fukunishi K, Kashima M, Satio S, Sakata-Haga H, Tokado H, Aoki I, Fukui Y
    • Journal Title

      Neuroscience 167

      Pages: 735-740

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ontogenetic pattern of gyrification in fetuses of cynomolgus monkeys2010

    • Author(s)
      Sawada, Kazuhiko
    • Journal Title

      Neuroscience

      Volume: 167 Pages: 735-740

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ontogenetic pattern of gyrification in fetuses of cynomolgus monkeys2010

    • Author(s)
      Sawada, Kazuhiko
    • Journal Title

      Neuroscience 167

      Pages: 735-740

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Developments of sulcal pattern and subcortical structures of the forebrain in cynomolgus monkey fetuses : 7-tesla magnetic resonance imaging provides high reproducibility of gross structural changes.2009

    • Author(s)
      Sawada K, Sun X-Z, Fukunishi K, Kashima M, Sakata-Haga H, Tokado H, Aoki I, Fukui Y
    • Journal Title

      Brain Struct Funct 213

      Pages: 469-480

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Surface rendering法によるサル胎仔大脳表面の三次元構築2009

    • Author(s)
      澤田和彦
    • Journal Title

      形の科学会誌 24

      Pages: 47-48

    • NAID

      10026051399

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Development of cerebral sulci and gyri in fetuses of cynomolgus monkeys (Macaca fascicularis).II.Gross observation of the medial surface.2008

    • Author(s)
      Kashima M, Sawada K, Fukunishi K, Sakata-Haga H, Tokado H, Fukui Y
    • Journal Title

      Brain Struct Funct 212

      Pages: 513-520

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Developments of sulcal pattern and subcortical structures of the forebrain in cynomolgus monkey fetuses : 7-tesla magnetic resonance imaging provides high reproducibility of gross structural changes.

    • Author(s)
      Sawada, Kazuhiko
    • Journal Title

      Brain Structure and Function (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Diffusion tensor analysis of the development of cerebral white matter bundle in cynomolgus monkey fetuses.2010

    • Author(s)
      澤田和彦、福西克弘、加島政利、齊藤茂芳、孫学智、坂田ひろみ、洲加本孝幸、青木伊知男、福井義浩
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] カニクイザル胎仔大脳における脳溝形成の定性的・定量的解析2010

    • Author(s)
      澤田和彦、福西克弘、加島政利、齊藤茂芳、孫学智、坂田ひろみ、洲加本孝幸、青木伊知男、福井義浩
    • Organizer
      第50回日本先天異常学会学術集会
    • Place of Presentation
      淡路
    • Related Report
      2010 Final Research Report
  • [Presentation] カニクイザル胎仔大脳における脳溝形成の定性的・定量的解析2010

    • Author(s)
      澤田和彦
    • Organizer
      第50回日本先天異常学会学術集会
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫)
    • Related Report
      2010 Annual Research Report
  • [Presentation] カニクイザル胎仔大脳における鳥距溝の形成と側脳室の形態的成熟の関係2010

    • Author(s)
      福西克弘
    • Organizer
      第50回日本先天異常学会学術集会
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫)
    • Related Report
      2010 Annual Research Report
  • [Presentation] カニクイザル大脳における側性発現の雌雄差2010

    • Author(s)
      今井統隆
    • Organizer
      第50回日本先天異常学会学術集会
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 生後発達に伴うカニクイザル大脳の主要脳溝長の変化2010

    • Author(s)
      坂本和仁
    • Organizer
      第50回日本先天異常学会学術集会
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Diffusion tensor analysis of the development of cerebral white matter bundle in cynomolgus monkey fetuses2010

    • Author(s)
      澤田和彦
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫)
    • Related Report
      2010 Annual Research Report
  • [Presentation] カニクイザル大脳における脳溝長の左右非対称性の生後発達2010

    • Author(s)
      坂本和仁
    • Organizer
      日本解剖学会第65回中国・四国地方会
    • Place of Presentation
      広島国際大学呉キャンパス(広島)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Quantitative assessment of cortical convolution of the developing cerebrum of cynomoleus monkey fetuses2009

    • Author(s)
      澤田和彦
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Surface rendering法によるサル胎仔大脳表面の三次元構築2009

    • Author(s)
      澤田和彦
    • Organizer
      第67回形の科学シンポジウム
    • Place of Presentation
      東京大学柏の葉キャンパス
    • Year and Date
      2009-06-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] カニクイザル胎仔における前脳の形態形成〜7テスラMRIを用いての解析〜2009

    • Author(s)
      澤田, 和彦
    • Organizer
      日本解剖学会総会・全国学術集会
    • Place of Presentation
      岡山理科大学
    • Year and Date
      2009-03-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] Quantitative assessment of cortical convolution of the developing cerebrum of cynomolgus monkey fetuses.2009

    • Author(s)
      澤田和彦、孫学智、福西克弘、加島政利、坂田ひろみ、洲加本孝幸、青木伊知男、福井義浩
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] カニクイザル胎仔における前脳の形態形成~7テスラMRIを用いての解析~2009

    • Author(s)
      澤田和彦、孫学智、福西克弘、加島政利、坂田ひろみ、洲加本孝幸、青木伊知男、福井義浩
    • Organizer
      第114回日本解剖学会総会\全国学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] カニクイザルの大脳における脳溝長の左右差2009

    • Author(s)
      今井統隆
    • Organizer
      第49回日本先天異常学会学術集会
    • Place of Presentation
      鹿児島市民文化ホール
    • Related Report
      2009 Annual Research Report
  • [Presentation] Analysis of cerebral sulcus development in cynomolgus monkey fetuses using 7 tesla MRI2008

    • Author(s)
      澤田, 和彦
    • Organizer
      日本神経科学大会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-07-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] Analysis of cerebral sulcus development in cynomolgus monkey fetuses using 7 tesla MRI.2008

    • Author(s)
      澤田和彦、孫学智、福西克弘、加島政利、坂田ひろみ、戸門洋志、福井義浩
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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