The role of Sox17 during mouse early endoderm to its delivertives
| Project/Area Number |
20590178
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General anatomy (including Histology/Embryology)
|
|---|
| Research Institution | Tokyo Medical and Dental University (2010-2011)
Kyorin University (2008-2009) |
|---|
Principal Investigator |
KANAI Masami 東京医科歯科大学, 実験動物センター, 教授 (70321883)
|
|---|
| Project Period (FY) |
2008 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
|
|---|
| Keywords | 内胚葉 / 発生・分化 / ノックアウトマウス / 腸管形成 / 肝臓 / 胆のう / 発生学 / 形態形成学 / 発生、分化 |
|---|
| Research Abstract |
The definitive gut endoderm give rise to various cell-types constituting digestive tract, liver, pancreas and associated visceral endoderm. In order to examine primordium endoderm(9. 5 dpc) development, we have cultured them for 3 days, and then analyzed the development/maturation in each explant. We have examined that chimeric study between Sox17 null ES cells introducing to wild blastcyst and their DNA array. Our observation strongly indicate that a critical role of Sox17 in the determination of the cell into the endoderm and its derivative organ in mammals. These findings lead us to the possibility that Sox17is one of the key genes for the isolation of the endodermal stem cells and obtaining of the endodermal cells derived from ES cells in the human therapeutic research for the future.
|
Report
(6 results)
Research Products
(81 results)
-
-
-
-
-
-
-
[Journal Article] Proteomic analysis of two types of exosomes in human whole saliva.2011
Author(s)
Ogawa Y, Miura Y, Harazono A, Kanai-Azuma M, Akimoto Y, Kawakami H, Yamaguchi T, Toda T, Endo T, Tsubuki M, Yanoshita R.
-
Journal Title
Biol Pharm Bull. 34
Pages: 13-23
Related Report
-
-
-
-
[Journal Article] Expression and function of mouse Sox17 gene in the specification of gallbladder/bile-duct progenitors during early foregut morphogenesis.2010
Author(s)
Uemura M, Hara K, Shitara H, Ishii R, Tsunekawa N, Miura Y, Kurohmaru M, Taya C, Yonekawa H, Kanai-Azuma M, Kanai Y.
-
Journal Title
Biochem Biophys Res Commun
Pages: 357-363
Related Report
-
-
-
-
-
[Journal Article] Expression and function of mouse Sox17 gene in the specification of gallbladder/bile-duct progenitors during early foregut morphogenesis.2009
Author(s)
Uemura M, Hara, K, Shitara H, Ishii R, Tsunekawa N, Miura Y, Kurohmaru M, Taya C, Yonekawa H, Kanai-Azuma M, Kanai Y.
-
Journal Title
Biochem.Biophys.Res.Commun. 391
Pages: 357-363
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] The membrane-spanning domain of CD98heavy chain promotes alpha(v)beta3 integrin signals in human extravillous trophoblasts.2008
Author(s)
Kabir-Salmani M, Fukuda MN, Kanai-Azuma M, Ahmed N, Shiokawa S, Akimoto Y, Sakai K, Nagamori S, Kanai Y, Sugihara K, Iwashita M.
-
Journal Title
Mol Endocrinol
Pages: 707-715
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
