Molecular mechanism of pituitary cell degeneration in a fatigued animal model.
| Project/Area Number |
20590194
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Osaka City University |
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Principal Investigator |
OGAWA Tokiko Osaka City University, 大学院・医学研究科, 特任助教 (30382229)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 持続的ストレス / 下垂体 / 細胞死 / 細胞増殖 / 疲労 / メラノトロフ / ソマトトロフ / CHOP/GADD153 / 下垂体中間葉 / 小胞体ストレス / ゴルジストレス / 疲労モデル / ドーパミン |
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| Research Abstract |
Cellular dysfunctions were observed in two types of pituitary cells of a fatigued rat model. One was melanotorophs cell death induced by abnormality of hypothalamic neurons, and the other was proliferating disorder of somatotrophs. As a result of molecular analysis, part of the mechanism inducing cellular dysfunctions were founded.
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Report
(4 results)
Research Products
(39 results)
