Molecular mechanism of pituitary cell degeneration in a fatigued animal model.

• Project/Area Number: 20590194
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Osaka City University
• Principal Investigator: OGAWA Tokiko Osaka City University, 大学院・医学研究科, 特任助教 (30382229)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 持続的ストレス / 下垂体 / 細胞死 / 細胞増殖 / 疲労 / メラノトロフ / ソマトトロフ / CHOP/GADD153 / 下垂体中間葉 / 小胞体ストレス / ゴルジストレス / 疲労モデル / ドーパミン

Research Abstract

Cellular dysfunctions were observed in two types of pituitary cells of a fatigued rat model. One was melanotorophs cell death induced by abnormality of hypothalamic neurons, and the other was proliferating disorder of somatotrophs. As a result of molecular analysis, part of the mechanism inducing cellular dysfunctions were founded.

Research Products

• [Journal Article] 抑肝散は慢性的複合ストレスラットの明期自発行動量増加を抑制する (2011)
  • Author(s): 小川登紀子、岡出朋子、池島(獅子王)信江、木山博資
  • Journal Title: 日本疲労学会誌 (掲載確定)
  • Peer Reviewed
• [Journal Article] Continious stress-induced dopamine dysfunction augmentats PAP-I and PAP-II expression in melanotrophs of the pituitary gland. (2011)
  • Author(s): Konishi H, Ogawa T, Kawahara S, Matsumoto S, Kiyama H
  • Journal Title: Biochemical and Biophysical Research Communications 407 Pages: 7-12
  • Peer Reviewed
• [Journal Article] Continious stress-induced dopamine dysfunction augmentats PAP-I and PAP-II expression in melanotrophs of the pituitary gland. (2011)
  • Author(s): Hiroyuki Konishi, Tokiko Ogawa, et al.
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 407 Pages: 7-12
  • Peer Reviewed
• [Journal Article] 抑肝散は慢性的複合ストレスラットの明期自発行動量増加を抑制する (2011)
  • Author(s): 小川登紀子, 他
  • Journal Title: 日本疲労学会誌 Volume: (掲載確定)
  • Peer Reviewed
• [Journal Article] The increase of alpha-melanocyte-stimulating hormone in the plasma of chronic fatigue syndrome patients. (2010)
  • Author(s): Shishioh-Ikejima N, Ogawa T, Yamagucti K, Watanabe Y, Kuratsune H, Kiyama H
  • Journal Title: BMC Neurology 10 Pages: 73-78
  • Peer Reviewed
• [Journal Article] Id1, Id2 and Id3 are induced in rat melanotrophs of the pituitary gland by dopamine suppression under continuous stress. (2010)
  • Author(s): Konishi H., Ogawa T., Nakagomi S., Inoue K., Thoyama M., Kiyama H
  • Journal Title: Neuroscience 169 Pages: 1527-1534
  • Peer Reviewed
• [Journal Article] 疲労ラット下垂体細胞の過労死とその機序 (2010)
  • Author(s): 小川登紀子、池島(獅子王)信江、木山博資
  • Journal Title: 日本疲労学会誌 5(2) Pages: 25-29
• [Journal Article] 疲労ラット下垂体細胞の過労死とその機序 (2010)
  • Author(s): 小川登紀子, 他
  • Journal Title: 日本疲労学会誌 Volume: 5 Pages: 25-29
• [Journal Article] Id1, Id2 and Id3 are induced in rat melanotrophs of the pituitary gland by dopamine suppression under continuous stress. (2010)
  • Author(s): Hiroyuki Konishi, Tokiko Ogawa, et al.
  • Journal Title: Neuroscience Volume: 169 Pages: 1527-1534
  • Peer Reviewed
• [Journal Article] The increase of alpha-melanocyte-stimulating hormone in the plasma of chronic fatigue syndrome patients. (2010)
  • Author(s): Nobue Shishioh-Ikejima, Tokiko Ogawa, et al.
  • Journal Title: BMC Neurology Volume: 10 Pages: 73-78
  • Peer Reviewed
• [Journal Article] Chronic stress elicits prolonged activation of a-MSH secretion and subsequent degeneration of melanotroph. (2009)
  • Author(s): Ogawa T., Shishioh-Ikejima N., Konishi H, Makino T. Sei H., Kiryu-Seo S, Tanaka M, Watanabe Y, Kiyama H
  • Journal Title: J Neurochem 109(11) Pages: 1389-1399
  • Peer Reviewed
• [Journal Article] Chronic stress elicits prolonged activation of α-MSH secretion and subse quent degeneration of melanotroph. (2009)
  • Author(s): Tokiko Ogawa
  • Journal Title: Journal of Neurochemistry (In press)
  • Peer Reviewed
• [Presentation] 持続的ストレスラット下垂体における細胞増殖阻害 (2010)
  • Author(s): 小川登紀子, 他
  • Organizer: 日本解剖学会第86回近畿支部学術集会
  • Place of Presentation: 大阪府立大学(大阪府)
  • Year and Date: 2010-11-27
• [Presentation] 疲労ラットにおけるソマトトロフの増殖阻害はERK1/2のリン酸化抑制を介して起こる (2010)
  • Author(s): 小川登紀子, 他
  • Organizer: 第6回日本疲労学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2010-06-26
• [Presentation] 疲労ラットにおけるソマトトロフの増殖阻害はERK1/2のリン酸化抑制を介して起こる (2010)
  • Author(s): 小川登紀子, 他
  • Organizer: 日本疲労学会総会・学術集会
  • Place of Presentation: 大阪産業創造館(大阪府)
  • Year and Date: 2010-06-26
• [Presentation] 下垂体細胞の過労死 (2010)
  • Author(s): 小川登紀子, 他
  • Organizer: 第15回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岩手
  • Year and Date: 2010-03-28
• [Presentation] 下垂体細胞の過労死の表情 (2010)
  • Author(s): 小川登紀子
  • Organizer: 日本解剖学会
  • Place of Presentation: 岩手
  • Year and Date: 2010-03-28
• [Presentation] Prolonged stress affects the hypothalamic dopamine system and causes degeneration of the pituitary cells. (2009)
  • Author(s): 小川登紀子, et al.
  • Organizer: Biennial Meeting of the Internationl Society for Neurochemistory
  • Place of Presentation: Busan, Korea
  • Year and Date: 2009-08-27
• [Presentation] Prolonged stress affects the hypothalamic dopamine system and causes degeneration of the pituitary cells. (2009)
  • Author(s): Tokiko Ogawa
  • Organizer: Biennial Meeting of the International Society for Neurochemistry
  • Place of Presentation: Busan, Korea
  • Year and Date: 2009-08-27
• [Presentation] 慢性ストレス負荷ラット下垂体中間葉においてドーパミンンレベル低下により誘導されるpancreatitis-associated protein Iの発現 (2009)
  • Author(s): 小西博之、小川登紀子, 他
  • Organizer: 日本神経化学会大会
  • Place of Presentation: 群馬
  • Year and Date: 2009-06-23
• [Presentation] 慢性ストレス負荷ラット下垂体中間葉においてドーパミンレベル低下により誘導されるpancreatitis-associated protein Iの発現 (2009)
  • Author(s): 小西博之
  • Organizer: 日本神経化学会大会
  • Place of Presentation: 群馬
  • Year and Date: 2009-06-23
• [Presentation] 疲労ラットにおける成長ホルモン産生細胞の機能阻害メカニズム (2009)
  • Author(s): 小川登紀子, 他
  • Organizer: 第5回日本疲労学会総会・学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2009-05-16
• [Presentation] 疲労ラットにおける成長ホルモン産生細胞の機能阻害メカニズム (2009)
  • Author(s): 小川登紀子
  • Organizer: 日本疲労学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-05-16
• [Presentation] 過労モデル動物における脳内変化とその影響 (2009)
  • Author(s): 木山博資
  • Organizer: 日本疲労学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-05-15
• [Presentation] 慢性疲労症候群早期患者における血中α-MSHレベルの上昇 (2009)
  • Author(s): 池島(獅子王)信江
  • Organizer: 日本疲労学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-05-15
• [Presentation] 疲労モデルラット下垂体中間葉においてドーパミンンレベル枯渇により誘導されるIdファミリー分子の発現 (2008)
  • Author(s): 小西博之、小川登紀子, 他
  • Organizer: 日本神経科学会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-28
• [Presentation] 疲労モデルラット下垂体中間葉においてドーパミン枯渇により誘導されるIdファミリー分子の発現 (2008)
  • Author(s): 小西 博之
  • Organizer: 日本神経科学会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-28
• [Presentation] 疲労モデルラットにおける炎症応答の変化 (2008)
  • Author(s): 池島(獅子王) 信江
  • Organizer: 日本解剖学会近畿支部学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2008-11-28
• [Presentation] Disorders of homeostasis centers in fatigued rat. (2008)
  • Author(s): Kiyama H., Shishioh-Ikejima N., Ogawa T.
  • Organizer: International Conference on Fatigue Science 2008
  • Place of Presentation: Okinawa
  • Year and Date: 2008-09-04
• [Presentation] Disorders of homeostasis centers in fatigued rat. (2008)
  • Author(s): Hiroshi Kiyama
  • Organizer: International Conference on Fatigue Science
  • Place of Presentation: Okinawa, Japan
  • Year and Date: 2008-09-04
• [Presentation] Prolonged fatigue exhibits the opposed proloferation regulations in the anterior and intermediare pituitary cells. (2008)
  • Author(s): 小川登紀子, et al.
  • Organizer: International Conference on Fatigue Science 2008
  • Place of Presentation: Okinawa
• [Presentation] Prolonged fatigue exhibits the opposed proloferation regulations in the anterior and intermediate pituitary cells. (2008)
  • Author(s): Tokiko Ogawa
  • Organizer: International Conference on Fatigue Science
  • Place of Presentation: Okinawa, Japan
• [Presentation] Alteration of inflammatory responses to LPS in rat fatigue model. (2008)
  • Author(s): Nobue Shishioh-Ikejima
  • Organizer: International Conference on Fatigue Science
  • Place of Presentation: Okinawa, Japan
• [Presentation] 持続的ストレスラットではGHRH 刺激によるソマトトロフの増殖が阻害される
  • Author(s): 小川登紀子, 他
  • Organizer: 第116回日本解剖学会総会・全国学術集会(震災により誌上開催)
• [Presentation] 持続的ストレスラットではGHRH刺激によるソマトトロフの増殖が阻害される
  • Author(s): 小川登紀子, 他
  • Organizer: 第116回日本解剖学会総会・全国学術集会
  • Place of Presentation: (震災により誌上開催)
• [Remarks] ホームページ
  • URL: http://www.med.osaka-cu.ac.jp/anatomy1/
• [Remarks]
  • URL: http://www.med.osaka-cu.ac.jp/anatomyl/
• [Patent(Industrial Property Rights)] 疲労度の判定方法および疲労度判定キット (2009)
  • Inventor(s): 木山博資、池島信江、小川登紀子、渡辺恭良、倉恒弘彦
  • Industrial Property Rights Holder: 大阪市立大学
  • Industrial Property Number: 2009-115685
  • Filing Date: 2009-05-12
• [Patent(Industrial Property Rights)] 疲労度の判定方法および疲労判定キット (2009)
  • Inventor(s): 木山博資、池島信江、小川登紀子、渡辺恭良、倉恒弘彦
  • Industrial Property Rights Holder: 大阪市立大学
  • Industrial Property Number: 2009-115685
  • Filing Date: 2009-05-12