| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
We examined changes in the ultrastructure of basement membrane of the cornea of diabetic GK rats. In the cornea of diabetic rats, many long-spacing collagen fibrils were observed in basement membrane. The antidiabetic agents significantly suppressed the formation of the long-spacing collagen. To explore biomarker proteins of which glcosylation level change in diabetic cornea, we carried out the proteomic analysis. Selected proteins that changed markedly in the O-GlcNAc level were identified by Mass Spectrometry analysis.
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