The movement mechanism of rafts associated with viruses to caveolae and transport of caveolar membrane.
| Project/Area Number |
20590201
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Fujita Health University |
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Principal Investigator |
NOMURA Ryuji Fujita Health University, 医学部, 講師 (20325161)
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| Co-Investigator(Kenkyū-buntansha) |
SENDA Takao 藤田保健衛生大学, 医学部, 教授 (10187875)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 細胞微細形態学 / コロナウイルス / ラフト / カベオラ / 蛍光 / 動態解析 / ウイルス侵入 |
|---|
| Research Abstract |
A virus infection starts from the entry into the cell. The virus entry has two types of the entry routes ; one is a route from the binding-site of the virus on the plasma membrane, while the other is a moving on the plasma membrane from binding-site to entry site. We reported that human coronavirus 229E used the later route when entry into the cell. Here, we studied the movement mechanism of the rafts associated with virus on the plasma embrane and revealed that membrane domains move to the virus entry site as flow when they are cross-linked by antibodies or viruses.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] The C-terminal domain of the adenomatous polyposis coli (Apc) protein is involved in thyroid morphogenesis and function.2011
Author(s)
Atsushi Yokoyama, Ryuji Nomura, Masafumi Kurosumi, Atsushi Shimomura, Takanori Onouchi, Akiko Iizuka-Kogo, Ron Smits, Naohisa Oda, Riccardo Fodde, Mitsuyasu Itoh, Takao Senda
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Journal Title
Medical Molecular Morphology (in press)
URL
Related Report
Peer Reviewed
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[Journal Article]2009
Author(s)
千田隆夫
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Journal Title
組織細胞化学2009「免疫組織化学の原理と応用」(日本組織細胞化学会編)(日本組織細胞化学会)
Pages: 1-18
Related Report
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