| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Research Abstract |
An increase in the affinity of the myofilaments for Ca^<2+> by lengthening the muscle or applying a Ca^<2+> sensitizer for myofilaments sustained triggered arrhythmias and increased their frequency in intact cardiac muscle. In failing hearts, dephosphorylation of troponin-I and an increase in Ca^<2+> sensitivity of the sarcoplasmic reticulum Ca^<2+> release channel increased the velocity of Ca^<2+> 2+ waves and the amplitude of delayed afterdepolarizations, thereby causing arrhythmogenesis. The affinity of the myofilaments for Ca^<2+> plays an important role in the occurrence of arrhythmias.
|
