Central effects of rat β calcitonin-gene related protein on energy homeostasis in rats

• Project/Area Number: 20590210
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General physiology
• Research Institution: University of Miyazaki
• Principal Investigator: SAWADA Hirotake University of Miyazaki, 医学部, 講師 (40332895)
• Co-Investigator(Renkei-kenkyūsha): MINAMINO Naoto 国立循環器病センター, 薬理部, 部長 (50124839)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2010: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 受容体 / 細胞内シグナル伝達 / 脳内カルシトニン受容体 / カルシトニン受容体刺激ペプチド / カルシトニン遺伝子関連ペプチド

Research Abstract

We demonstrated that rat βCGRP can function as a specific ligand for CT-R and a catabolic signaling molecule in the rat CNS.
These results suggest that rat βCGRP functions as a specific ligand for the CT-R and a catabolic signaling molecule in the CNS.

Research Products

• [Presentation] Peptidomics-baseddiscovery of biologically active peptides (2010)
  • Author(s): Minamino Naoto
  • Organizer: International Symposium : Frontier in Biologically Active Peptide Research
  • Place of Presentation: Kobe
  • Year and Date: 2010-12-07
• [Presentation] 脳内カルシトニン受容体の機能解析および内因性リガンド探索 (2010)
  • Author(s): 澤田浩武
  • Organizer: 第14回小児分子内分泌研究会
  • Place of Presentation: 北海道
  • Year and Date: 2010-07-03
• [Presentation] 脳内カルシトニン受容体の機能解析 (2010)
  • Author(s): 澤田浩武
  • Organizer: 第14回小児分子内分泌研究会
  • Place of Presentation: 大沼国際セミナーハウス
  • Year and Date: 2010-07-03
• [Presentation] 脳内カルシトニンの機能解析 (2009)
  • Author(s): 澤田浩武
  • Organizer: ヒューマトロープ発売20周年記念講演会
  • Place of Presentation: 福岡
  • Year and Date: 2009-11-21
• [Presentation] 脳内カルシトニン受容体の機能解析 (2009)
  • Author(s): 澤田浩武
  • Organizer: ヒューマトロープ発売20周年記念講演会
  • Place of Presentation: 博多エクセルホテル東急
  • Year and Date: 2009-11-21
• [Remarks] ホームページ
  • URL: http://www.ncvc.go.jp/res/divisions/pharmacology/001/index.html#-a