| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Research Abstract |
Voltage-gated proton channels (H^+ channels) are highly sensitive to temperature. The temperature-sensitivity of whole-cell H^+ currents consisted of two phases, a high Q_<10> phase over the lower temperature ranges (<～30℃) and a low Q_<10> phase at higher temperatures. We revealed the low Q_<10> phase represented the process of H^+ permeation through the channel pore and the access resistance to the pore, and the high Q_<10> phase, recruitment of active channels in addition to the permeation process. Actin cytoskeletal network and lipid raft structure are suggested to underlie the temperature-sensitive recruitment of H^+ channels.
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