Analysis of bi-directional signal transduction elicited by adhesion between leukocyte and endothelial cells
| Project/Area Number |
20590214
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Osaka City University |
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Principal Investigator |
FUJITA Hisakazu Osaka City University, 大学院・医学研究科, 講師 (30212187)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Takayuki 大阪市立大学, 大学院・医学研究科, 講師 (50343413)
KITAGAWA Seiichi 大阪市立大学, 大学院・医学研究科, 教授 (50133278)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 細胞間接着 / カルパイン / 血管内皮細胞 / 白血球 / 細胞間接着分子 / 低分子量Gタンパク質 |
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| Research Abstract |
1)We found the molecular interaction between JAML (Junctional adhesion molecule-like) and ESAM (Endothelial cell-selective adhesion molecule). 2) Potent calpain inhibitors stimulate cell functions via activation of human formyl peptide receptor and human formyl peptide receptor-like 1.
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Report
(4 results)
Research Products
(16 results)
