Improvement of exercise performance by gene therapy
Project/Area Number |
20590215
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General physiology
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Research Institution | Kio University |
Principal Investigator |
SAKATA Susumu 畿央大学, 健康科学部, 教授 (20142383)
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Co-Investigator(Kenkyū-buntansha) |
NAKATANI Akira 奈良教育大学, 教育学部, 教授 (70116284)
TAKAKI Miyako 奈良県立医科大学, 医学部, 教授 (00033358)
|
Project Period (FY) |
2008 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
|
Keywords | 遺伝子治療 / SERCA2a / 不全心 / 再生医学 / 運動生理学 / ラット / 運動パフォーマンス / SERCA |
Research Abstract |
Systolic/diastolic blood pressures(BP) in aortic-banding(Band) group were lower than those in sham-operation(Sham) group 6-18 months after the operation. Likewise, endurance capacity was lower in"Band"than in"Sham"18 months after the operation. However, systolic BP and endurance capacity in"Band"could be increased by 3 week-voluntary wheel-running exercise. To conclude, these results suggest that daily light exercise is a potential strategy for improving BP and endurance capacity in patients with heart failure.
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Report
(6 results)
Research Products
(29 results)
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[Journal Article] Gene remodeling in type 2 diabetic cardiomyopathy and its phenotypic rescue with SERCA2a2009
Author(s)
Karakikes, I., Kim, M., Hadri, L., Sakata, S., Sun, Y., Zhang, W., Chemaly, E.R., Hajjar, R.J., Lebeche, D.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Reversal of cardiac dysfunction following long term expression of SERCA2a by gene transfer in a pre-clinical model of heart failure2008
Author(s)
Kawase Y, Ly HQ, Prunier F, Lebeche D, Shi Y, Jin H, Hadri L, Yoneyama R, Hoshino K, Takewa Y, Sakata S, Peluso R, Zsebo K, Gwathmey JK, Tardif J-C, Tanguay J-F & Hajjar RJ
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Journal Title
J Am Coll Cardiol
Volume: 51
Issue: 11
Pages: 1112-1119
DOI
Related Report
Peer Reviewed
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[Journal Article] Reversal of cardiac dysfunction after long-term expression of SERCA2a by gene transfer in a pre-clinical model of heart failure2008
Author(s)
Kawase Y, Ly HQ, Prunier F, Lebeche D, Shi Y, Jin H, Hadri L, Yoneyama R, Hoshino K, Takewa Y, Sakata S, Peluso R, Zsebo K, Gwathmey JK, Tardif JC, Tanguay JF, Hajjar RJ
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Journal Title
Journal of the American College of Cardiology 51
Pages: 1112-1119
Related Report
Peer Reviewed
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[Presentation] Left ventricular mechanoenergetics during development of cardiac hypertrophy and failure.2010
Author(s)
Sakata S, Sakata N, Sakata Y, Lebeche D, Hanaoka T, Nishii Y, Chemaly ER, Kawase Y, Takaki M, Hajjar RJ
Organizer
20th World Congress of the International Society for Heart Research
Place of Presentation
Kyoto, Japan
Related Report
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