Improvement of exercise performance by gene therapy

• Project/Area Number: 20590215
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General physiology
• Research Institution: Kio University
• Principal Investigator: SAKATA Susumu 畿央大学, 健康科学部, 教授 (20142383)
• Co-Investigator(Kenkyū-buntansha): NAKATANI Akira 奈良教育大学, 教育学部, 教授 (70116284) ; TAKAKI Miyako 奈良県立医科大学, 医学部, 教授 (00033358)
• Project Period (FY): 2008 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
• Keywords: 遺伝子治療 / SERCA2a / 不全心 / 再生医学 / 運動生理学 / ラット / 運動パフォーマンス / SERCA

Research Abstract

Systolic/diastolic blood pressures(BP) in aortic-banding(Band) group were lower than those in sham-operation(Sham) group 6-18 months after the operation. Likewise, endurance capacity was lower in"Band"than in"Sham"18 months after the operation. However, systolic BP and endurance capacity in"Band"could be increased by 3 week-voluntary wheel-running exercise. To conclude, these results suggest that daily light exercise is a potential strategy for improving BP and endurance capacity in patients with heart failure.

Research Products

• [Journal Article] Development of a pre-clinical model of ischemic cardiomyopathy in swine (2011)
  • Author(s): Ishikawa K, Ladage D, Takewa Y, Yaniz E, Chen J, Tilemann L, Sakata S, Badimon JJ, Hajjar RJ & Kawase Y
  • Journal Title: Am J Physiol Heart Circ Physiol Volume: 301 Issue: 2 Pages: H530-H537
  • DOI: 10.1152/ajpheart.01103.2010
  • Peer Reviewed
• [Journal Article] Development of a preclinical model of ischemic cardiomyopathy in swine (2011)
  • Author(s): Ishikawa K, Ladage D、Takewa Y, Yaniz E, Chen J, Tilemann L, Sakata S, Badimon JJ, Hajjar RJ, Kawase Y
  • Journal Title: Am J Physiol Heart & Circ Physiol Volume: 301
  • Peer Reviewed
• [Journal Article] Development of a preclinical model of ischemic cardiomyopathy in swine. (2011)
  • Author(s): Ishikawa K, Ladage D, Takewa Y, Yaniz E, Chen J, Tilemann L, Sakata S, Badimon JJ, Hajjar RJ, Kawase Y
  • Journal Title: Am J Physiol Heart & Circ Physiol
  • Peer Reviewed
• [Journal Article] Development of a preclinical model of ischemic cardiomyopathy in swine (2011)
  • Author(s): Ishikawa K, Ladage D, Takewa Y, Yaniz E, Chen J, Tilemann L, Sakata S, Badimon JJ, Hajjar RJ, Kawase Y
  • Journal Title: Am J Physiol Heart & Circ Physiol
  • Peer Reviewed
• [Journal Article] Gene remodeling in type 2 diabetic cardiomyopathy and its phenotypic rescue with SERCA2a (2009)
  • Author(s): Karakikes I, Kim M, Hadri L, Sakata S, Sun Y, Zhang W, Chemaly ER, Hajjar RJ & Lebeche D
  • Journal Title: PLoS ONE Volume: 4(7) Issue: 7 Pages: e6474-e6474
  • DOI: 10.1371/journal.pone.0006474
  • Peer Reviewed
• [Journal Article] Gene remodeling in type 2 diabetic cardiomyopathy and its phenotypic rescue with SERCA2a (2009)
  • Author(s): Karakikes I, Kim M, Hadri L, Sakata S, Sun Y, Zhang W, Chemaly ER, Hajjar RJ, Lebeche D
  • Journal Title: PLoS ONE 4(7) Pages: 6474-6474
  • Peer Reviewed
• [Journal Article] Gene remodeling in type 2 diabetic cardiomyopathy and its phenotypic rescue with SERCA2a (2009)
  • Author(s): Karakikes, I., Kim, M., Hadri, L., Sakata, S., Sun, Y., Zhang, W., Chemaly, E.R., Hajjar, R.J., Lebeche, D.
  • Journal Title: PLoS ONE 4
  • Peer Reviewed
• [Journal Article] Role of resistin in cardiac contractility and hypertrophy (2008)
  • Author(s): Kim M, Oh JK, Sakata S, Liang LF, Park WJ, Hajjar RJ & Lebeche D
  • Journal Title: J Mol & Cell Cardiol Volume: 45 Issue: 2 Pages: 270-280
  • DOI: 10.1016/j.yjmcc.2008.05.006
  • Peer Reviewed
• [Journal Article] Reversal of cardiac dysfunction following long term expression of SERCA2a by gene transfer in a pre-clinical model of heart failure (2008)
  • Author(s): Kawase Y, Ly HQ, Prunier F, Lebeche D, Shi Y, Jin H, Hadri L, Yoneyama R, Hoshino K, Takewa Y, Sakata S, Peluso R, Zsebo K, Gwathmey JK, Tardif J-C, Tanguay J-F & Hajjar RJ
  • Journal Title: J Am Coll Cardiol Volume: 51 Issue: 11 Pages: 1112-1119
  • DOI: 10.1016/j.jacc.2007.12.014
  • Peer Reviewed
• [Journal Article] Reversal of cardiac dysfunction after long-term expression of SERCA2a by gene transfer in a pre-clinical model of heart failure (2008)
  • Author(s): Kawase Y, Ly HQ, Prunier F, Lebeche D, Shi Y, Jin H, Hadri L, Yoneyama R, Hoshino K, Takewa Y, Sakata S, Peluso R, Zsebo K, Gwathmey JK, Tardif JC, Tanguay JF, Hajjar RJ
  • Journal Title: Journal of the American College of Cardiology 51 Pages: 1112-1119
  • Peer Reviewed
• [Journal Article] Role of resistin in cardiac contractility and hypertrophy (2008)
  • Author(s): Kim M, Oh JK, Sakata S, Liang L, Park W, Hajjar RJ, Lebeche D
  • Journal Title: Journal of Molecular and Cellular Cardiology 45 Pages: 270-280
  • Peer Reviewed
• [Presentation] Voluntary wheel-running lowers blood pressure and elevates endurance capacity in rats (2011)
  • Author(s): Nishii Y, Hanaoka T, Iwami K, Imagita H, Minematsu A, Waki H, Nakatani A, Kaneko A & Sakata S
  • Organizer: The 7th Congress of the Federation of Asian and Oceanian Physiological Societies
  • Place of Presentation: Taipei, Taiwan
• [Presentation] Effects of different high fat diets on FABP content in rat skeletal muscles (2011)
  • Author(s): Ishizawa R, Sakata S & Nakatani A
  • Organizer: 58th Annual Meeting of American College of Sports Medicine
  • Place of Presentation: Denver, USA
• [Presentation] Assessing myocardial systolic function : are we moving beyond the end-systolic elastance of the left ventricle (2011)
  • Author(s): Chemaly ER, Chaanine A, Sakata S & Hajjar RJ
  • Organizer: 2011 North American Section Meeting International Society for Heart Research
  • Place of Presentation: Philadelphia, USA
• [Presentation] Voluntary wheel running decreases blood pressure and increases endurance capacity in rats (2011)
  • Author(s): Sakata S, Nishii Y, Hanaoka T, Ishizawa R, Iwami K, Minematsu A, Imagita H, Itou A, Waki H & Nakatani A
  • Organizer: The Joint Meeting of The 88th Annual Meeting of the Physiological Society of Japan and The 116th Annual Meeting of the Japanese Association of Anatomists
  • Place of Presentation: Japan
• [Presentation] Assessing myocardial systolic function : are we moving beyond the end-systolic elastance of the left ventricle? (2011)
  • Author(s): Chemaly ER, Chaanine A, Sakata S, Hajjar RJ
  • Organizer: North American Section Meeting International Society for Heart Research
  • Place of Presentation: Philadelphia, USA
• [Presentation] Voluntary wheel-running lowers blood pressure and elevates endurance capacity in rats (2011)
  • Author(s): Nishii Y, Hanaoka T, Iwami K, Imagita H, Minematsu A, Waki H, Nakatani A, Kaneko A, Sakata S
  • Organizer: 7th Congress of the Federation of Asian and Oceanian Physiological Societies
  • Place of Presentation: Taipei, Taiwan
• [Presentation] Effects of various bone loss factors on bone micro architecture in female rats (2011)
  • Author(s): Minematsu A, Iwaki K, Nishii Y, Hanaoka T, Imagita H, Sakata S
  • Organizer: 2011 Annual Meeting of the American Society for Bone and Mineral Research
  • Place of Presentation: San Diego, USA
• [Presentation] Voluntary wheel running decreases blood pressure and increases endurance capacity in rats. (2011)
  • Author(s): Sakata S, Nishii Y, Hanaoka T, Ishizawa R, Iwami K, Minematsu A, Imagita H, Itou A, Waki H, Nakatani A
  • Organizer: The Joint Meeting of The 88th Annual Meeting of the Physiological Society of Japan and The 116th Annual Meeting of the Japanese Association of Anatomists
  • Place of Presentation: Japan
• [Presentation] Voluntary wheel running decreases blood pressure and increases endurance capacity in rats (2011)
  • Author(s): Sakata S, Nishii Y, Hanaoka T, Ishizawa R, Iwami K, Minematsu A, Imagita H, Itou A, Waki H, Nakatani A
  • Organizer: The Joint Meeting of The 88th Annual Meeting of the Physiofogical Society of Japan and The 116th Annual Meeting of the Japanese Association of Anatomists
  • Place of Presentation: Japan
• [Presentation] Left ventricular mechanoenergetics during development of cardiac hypertrophy and failure (2010)
  • Author(s): Sakata S, Sakata N, Sakata Y, Lebeche D, Hanaoka T, Nishii Y, Chemaly ER, Kawase Y, Takaki M, Hajjar RJ
  • Organizer: 20th Worfd Congress of the International Society for Heart Research
  • Place of Presentation: Kyoto International Conference Center (Kyoto)
  • Year and Date: 2010-05-13
• [Presentation] Left ventricular mechanoenergetics during development of cardiac hypertrophy and failure (2010)
  • Author(s): Sakata S, Sakata N, Sakata Y, Lebeche D, Hanaoka T, Nishii Y, Chemaly ER, Kawase Y, Takaki M & Hajjar RJ
  • Organizer: 20th World Congress of the International Society for Heart Research
  • Place of Presentation: Kyoto, Japan
• [Presentation] Left ventricular mechanoenergetics during development of cardiac hypertrophy and failure. (2010)
  • Author(s): Sakata S, Sakata N, Sakata Y, Lebeche D, Hanaoka T, Nishii Y, Chemaly ER, Kawase Y, Takaki M, Hajjar RJ
  • Organizer: 20th World Congress of the International Society for Heart Research
  • Place of Presentation: Kyoto, Japan
• [Presentation] Dynamic changes in left ventricular mechanoenergetics during development of cardiac hypertrophy and failure (2009)
  • Author(s): Sakata S, Sakata N, Sakata Y, Lebeche D, Hanaoka T, Chemaly ER, Takaki M & Hajjar RJ
  • Organizer: 36th International Congress of Physiological Sciences
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2009-07-08
• [Presentation] Dynamic changes in left ventricular mechanoenergetics during development of cardiac hypertrophy and failure. (2009)
  • Author(s): Sakata S, Sakata N, Sakata Y, Lebeche D, Hanaoka T, Chemaly ER, Takaki M, Hajjar RJ
  • Organizer: 36th International Congress of Physiological Sciences
  • Place of Presentation: Kyoto, Japan
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