| Project/Area Number |
20590218
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Keio University |
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Principal Investigator |
OKADA Yasumasa Keio University, 医学部, 准教授 (80160688)
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| Co-Investigator(Kenkyū-buntansha) |
OKU Yoshitaka 兵庫医科大学, 医学部, 教授 (20252512)
MIWAKEICHI Fumikazu 統計数理研究所, モデリング研究系, 准教授 (30360647)
横田 茂文 島根大学, 医学部, 助教 (50294369)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 呼吸調節 / 膜電位イメージング / 高位頚髄呼吸神経細胞群 / 呼吸リズム / 呼吸パターン形成 / 横隔神経核 / 横隔膜 / 斜角筋 / 呼吸神経回路網 / 脊髄 / 頚髄 / 呼吸リズム形成 |
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| Research Abstract |
To elucidate the function and anatomy of the respiratory neuron groups in the cervical spinal cord that are involved in respiratory rhythm and pattern generation, we conducted voltage imaging, electrophysiological recording and immunohistological analyses in in vitro and in situ rat preparations. We found a novel respiratory neuron group in the high (C1-C2) cervical spinal cord, and reported it as "High Cervical Spinal Cord Respiratory Neuron Group (HCRG)". We also analyzed the spatiotemporal profiles of the respiratory neurons at the level of the phrenic nucleus (C3-C5 level), and found that phrenic and scalene motoneurons are located at the same level but separately with distinct activity patterns. These findings will be the basis to better understand the pathophysiology of respiratory disturbance accompanied with cervical spinal cord injury and to develop new treatment modality.
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