Role of the orexin neurons in body temperature regulation

• Project/Area Number: 20590226
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Kagoshima University
• Principal Investigator: KUWAKI Tomoyuki Kagoshima University, 医歯学総合研究科, 教授 (80205260)
• Research Collaborator: ZHANG Wei 千葉大学, 医学研究院, 特任研究員 ; SUNANAGA Jinko 鹿児島大学, 医歯学総合研究科, 大学院生 ; TAKAHASHI Yoshiko 鹿児島大学, 医歯学総合研究科, 大学院生
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: オレキシン / 視床下部 / 体温調節 / ストレス / オレキシ / 発熱物質 / 低温環境 / 高温環境

Research Abstract

Possible role of orexin (hypocretin), a hypothalamic neuropeptide, in body temperature regulation was investigated using genetically engineered mice. Orexin containing neurons are indispensable for tress-induced thermogenesis although they minimally contribute to basal body temperature. Surprisingly, not orexin but co-transmitters contained in the orexin neurons are important for stress-induced thermogenesis.

Research Products

• [Journal Article] Orexin neurons are indispensable for stress-induced thermogenesis in mice. (2010)
  • Author(s): Zhang W, Sunanaga J, Takahashi Y, Mori T, Sakurai T, Kanmura Y, Kuwaki T
  • Journal Title: J Physiol 588 Pages: 4117-4129
  • Peer Reviewed
• [Journal Article] Orexin neurons as arousal-associated modulators of central cardiorespiratory regulation. (2010)
  • Author(s): Kuwaki T, Zhang W
  • Journal Title: Resp Physiol Neurobiol 174 Pages: 43-54
  • Peer Reviewed
• [Journal Article] State-dependent central chemoreception : A role of orexin. (2010)
  • Author(s): Kuwaki T, Li A, Nattie E
  • Journal Title: Resp Physiol Neurobiol 173 Pages: 223-229
  • Peer Reviewed
• [Journal Article] Hypothalamic modulation of breathing. (2010)
  • Author(s): 桑木共之
  • Journal Title: Adv Exp Med Biol 669 Pages: 243-247
  • Peer Reviewed
• [Journal Article] Monoaminergic neuronal changes in orexin deficient mice. (2010)
  • Author(s): Mori T, Ito S, Kuwaki T, Yanagisawa M, Sawaguchi T
  • Journal Title: Neuropharmacology 58 Pages: 826-832
  • Peer Reviewed
• [Journal Article] 神経性循環制御:an update (2010)
  • Author(s): 桑木共之
  • Journal Title: 循環制御 30 Pages: 142-148
• [Journal Article] 視床下部による自律系の統合調節:オレキシンの役割 (2010)
  • Author(s): 桑木共之
  • Journal Title: 自律神経 47 Pages: 236-243
  • NAID: 10026905693
• [Journal Article] Orexin neurons are indispensable for stress-induced thermogenesis in mice. (2010)
  • Author(s): Zhang W, et al.
  • Journal Title: Journal of Physiology (London) Volume: 588 Pages: 4117-4129
  • Peer Reviewed
• [Journal Article] Orexin neurons as arousal-associated modulators of central cardiorespiratory regulation. (2010)
  • Author(s): Kuwaki T, et al.
  • Journal Title: Respiration Physiology and Neurobiology Volume: 174 Pages: 43-54
  • Peer Reviewed
• [Journal Article] Monoaminergic neuronal changes in orexin deficient mice. (2010)
  • Author(s): Mori T, et al.
  • Journal Title: Neuropharmacology Volume: 58 Pages: 826-832
  • Peer Reviewed
• [Journal Article] Hypothalamic modulation of breathing. (2010)
  • Author(s): Kuwaki T
  • Journal Title: Advances in Experimental Medicine and Biology Volume: 669 Pages: 243-247
  • Peer Reviewed
• [Journal Article] State-dependent central chemoreception : A role of orexin. (2010)
  • Author(s): Kuwaki T, et al.
  • Journal Title: Respiration Physiology and Neurobiology Volume: 173 Pages: 223-229
  • Peer Reviewed
• [Journal Article] 神経性循環制御:an update (2010)
  • Author(s): 桑木共之
  • Journal Title: 循環制御 Volume: 30 Pages: 142-148
• [Journal Article] 視床下部による自律系の統合調飾:オレキシンの役割 (2010)
  • Author(s): 桑木共之
  • Journal Title: 自律神経 Volume: 47 Pages: 236-243
• [Journal Article] Monoaminergic neuronal changes in orexin deficient mice (2010)
  • Author(s): Mori T, et al.
  • Journal Title: Neuropharmacology (in press)
  • Peer Reviewed
• [Journal Article] Attenuated phrenic long-term facilitation in orexin neuron-ablated mice. (2009)
  • Author(s): Toyama S, Sakurai T, Tatsumi K, Kuwaki T
  • Journal Title: Resp Physiol Neurobiol 168 Pages: 295-302
  • Peer Reviewed
• [Journal Article] CO2 activates orexin-containing neurons in mice. (2009)
  • Author(s): Sunanaga J, Deng BS, Zhang W, Kanmura Y, Kuwaki T
  • Journal Title: Resp Physiol Neurobiol 16 Pages: 184-186
  • Peer Reviewed
• [Journal Article] Orexin neurons in the hypothalamus mediate cardiorespiratory responses induced by disinhibition of the amygdala and bed nucleus of the stria terminalis. (2009)
  • Author(s): Zhang W, Zhang N, Sakurai T, Kuwaki T
  • Journal Title: Brain Res 1262 Pages: 25-37
  • Peer Reviewed
• [Journal Article] 視床下部による自律機能の調節におけるオレキシンの役割 (2009)
  • Author(s): 桑木共之
  • Journal Title: 生体の科学 60 Pages: 474-475
• [Journal Article] Orexin neurons in the hypothalamus mediate cardiorespiratory responses induced by disinhibition of the amygdala and bed nucleus of the stria terminalis (2009)
  • Author(s): Zhang W, et al.
  • Journal Title: Brain Research 1262 Pages: 25-37
  • Peer Reviewed
• [Journal Article] C0_2 activates orexin-containing neurons in mice (2009)
  • Author(s): Sunanaga J, et al.
  • Journal Title: Respiration Physiology and Neurobiology 166 Pages: 184-186
  • Peer Reviewed
• [Journal Article] Attenuated phrenic long-term facilitation in orexin neuron-ablated mice (2009)
  • Author(s): Toyama S, et al.
  • Journal Title: Respiration Physiology and Neurobiology 168 Pages: 295-302
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 桑木共之(分担)
  • Journal Title: 睡眠学(朝倉書店)
• [Journal Article] Orexin neurons in the hypothalamus mediate cardiorespiratory responses induced by disinhibition of the amygdala and bed nucleus of the stria terminalis. (2009)
  • Author(s): Zhang W, et al.
  • Journal Title: Brain Research (in press)
  • Peer Reviewed
• [Journal Article] Orexin-containing neuron contributes stxess-induced thermogenesis. (2009)
  • Author(s): Kuwaki T., Zhang W.
  • Journal Title: Korean J. Physiol. Pharmacol. 13 Pages: 172-174
• [Journal Article] Orexinergic modulation of breathing across vigilance states. (2008)
  • Author(s): 桑木共之
  • Journal Title: Resp Physiol Neurobiol 164 Pages: 204-212
  • Peer Reviewed
• [Journal Article] Emotional and state-dependent modification of cardiorespiratory function : role of orexinergic neurons. (2008)
  • Author(s): Kuwaki T, Zhang W, Nakamura A, Deng BS
  • Journal Title: Autonom Neurosci : Basic Clin 142 Pages: 11-16
  • Peer Reviewed
• [Journal Article] Orexin links emotional stress to autonomic functions.
  • Author(s): 桑木共之
  • Journal Title: Autonom Neurosci : Basic Clin in press
  • Peer Reviewed
• [Presentation] オレキシンによる行動・呼吸調節ネットワーク (2011)
  • Author(s): 桑木共之
  • Organizer: 第88回日本生理学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-28
• [Presentation] Orexin neurons are involved in the brain-coordinated ultradian rhythm. (2011)
  • Author(s): 宮田紘平, 他
  • Organizer: 第88回日本生理学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-28
• [Presentation] 超日生体リズムと脳内神経機構 (2010)
  • Author(s): 宮田紘平, 他
  • Organizer: 第38回自律神経生理研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-12-04
• [Presentation] PGE2による発熱に関与する神経伝達物質 (2010)
  • Author(s): 鮫島光平, 他
  • Organizer: 第38回自律神経生理研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-12-04
• [Presentation] Stress-induced thermogenesis depends on orexin neurons. (2010)
  • Author(s): Sunanaga J, Zhang W, Takahashi Y, Mori T, Sakurai T, Kanmura Y, Kuwaki T
  • Organizer: 9th Japan-Korea Joint Symposium on Brain Sciences, and Cardiac and Smooth Muscles
  • Place of Presentation: Kagoshima (Symposiast)
  • Year and Date: 2010-11-25
• [Presentation] Stress-induced hyperthermia is mediated by orexin neurons. (2010)
  • Author(s): Sunanaga J, et al.
  • Organizer: American Society of Anesthesiologists Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-10-17
• [Presentation] Orexin neurons mediate prostaglandin E2-induced fever. (2010)
  • Author(s): Takahashi Y, et al.
  • Organizer: American Society of Anesthesiologists Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-10-17
• [Presentation] Stress-induced hyperthermia is mediated by orexin neurons. (2010)
  • Author(s): Sunanaga J, Takahashi Y, Kanmura Y, Kuwaki T
  • Organizer: American Society of Anesthesiologists Annual Meeting
  • Place of Presentation: San Diego USA
  • Year and Date: 2010-10-16
• [Presentation] Orexin neurons mediate prostaglandin E2-induced fever (2010)
  • Author(s): Takahashi Y, Sunanaga J, Kanmura Y, Kuwaki T
  • Organizer: American Society of Anesthesiologists Annual Meeting
  • Place of Presentation: San Diego USA
  • Year and Date: 2010-10-16
• [Presentation] Orexin : A possible link between behavior and autonomic functions. The NeuroPhysiome : Bridging computational neuroscience and systems biology. (2010)
  • Author(s): 桑木共之
  • Organizer: US-JAPAN Brain Research Cooperative Program Workshop
  • Place of Presentation: Okinawa (Invited Symposiast)
  • Year and Date: 2010-10-05
• [Presentation] Orexin : A possible link between behavior and autononuc functions. (2010)
  • Author(s): Kuwaki T
  • Organizer: The Neuro Physiome : Bridging computational neuroscience and systems biology.
  • Place of Presentation: Okinawa, Japan
  • Year and Date: 2010-10-04
• [Presentation] オレキシン含有ニューロンはストレス時の発熱反応に関与している (2010)
  • Author(s): 砂永仁子, 他
  • Organizer: 第33回日本神経科学学会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-03
• [Presentation] オレキシンニューロンはプロスタグランジンE2による発熱に関与している (2010)
  • Author(s): 高橋佳子, 他
  • Organizer: 第33回日本神経科学学会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-03
• [Presentation] 視床下部オレキシン神経:自律系と体性系との接点 (2010)
  • Author(s): 桑木共之
  • Organizer: 第8回交感神経とアンジオテンシンII研究会
  • Place of Presentation: 福岡(招待講演)
  • Year and Date: 2010-08-07
• [Presentation] 視床下部オレキシン神経:自律系と体性系との接点 (2010)
  • Author(s): 桑木共之
  • Organizer: 第8回交感神経とアンジオテンシンII研究会
  • Place of Presentation: 福岡
  • Year and Date: 2010-08-07
• [Presentation] ストレス時の発熱はオレキシン含有ニューロンを介する (2010)
  • Author(s): 砂永仁子, 他
  • Organizer: 日本麻酔科学会第57回学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2010-06-04
• [Presentation] プロスタグランディソE2による発熱はオレキシン含有ニューロンを介する (2010)
  • Author(s): 高橋佳子, 他
  • Organizer: 日本麻酔科学会第57回学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2010-06-04
• [Presentation] ストレス時の発熱はオレキシン含有ニューロンを介する (2010)
  • Author(s): 砂永仁子、高橋佳子、張薇、桜井武、上村裕一、桑木共之
  • Organizer: 日本麻酔科学会第57回学術集会
  • Place of Presentation: 福岡(優秀演題)
  • Year and Date: 2010-06-03
• [Presentation] プロスタグランディンE2による発熱はオレキシン含有ニューロンを介する (2010)
  • Author(s): 高橋佳子、砂永仁子、張薇、桜井武、上村裕一、桑木共之
  • Organizer: 日本麻酔科学会第57回学術集会
  • Place of Presentation: 福岡(優秀演題)
  • Year and Date: 2010-06-03
• [Presentation] 自律機能の中枢神経による調節 (2010)
  • Author(s): 桑木共之
  • Organizer: 第87回日本生理学会大会
  • Place of Presentation: 盛岡(シンポジウム招待講演)
  • Year and Date: 2010-05-20
• [Presentation] 自律機能の中枢神経による調節 (2010)
  • Author(s): 桑木共之
  • Organizer: 第87回日本生理学会大会
  • Place of Presentation: 盛岡
  • Year and Date: 2010-05-20
• [Presentation] ストレス時の発熱はオレキシンニューロンを介する (2010)
  • Author(s): 砂永仁子, 他
  • Organizer: 第87回日本生理学会大会
  • Place of Presentation: 盛岡
  • Year and Date: 2010-05-20
• [Presentation] プロスタグランディンE2による発熱はオレキシンニューロンを介する (2010)
  • Author(s): 高橋佳子, 他
  • Organizer: 第87回日本生理学会大会
  • Place of Presentation: 盛岡
  • Year and Date: 2010-05-20
• [Presentation] Orexin and the Control of Breathing : Lessons from orexin knockout mice. (2010)
  • Author(s): 桑木共之
  • Organizer: Experimental Biology Meeting
  • Place of Presentation: Anaheim USA (Chair & Lecture in a Symposium)
  • Year and Date: 2010-04-25
• [Presentation] Orexin and the Control of Breathing : Lessons from orexin knockout mice. (2010)
  • Author(s): Kuwaki T
  • Organizer: Experimental Biology 2010
  • Place of Presentation: Anaheim, USA
  • Year and Date: 2010-04-25
• [Presentation] 二酸化炭素換気応答におけるオレキシン含有神経の役割 (2009)
  • Author(s): 桑木共之, 他
  • Organizer: 第37回自律神経生理研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-12-05
• [Presentation] 視床下部による自律系の統合調節:オレキシンの役割 (2009)
  • Author(s): 桑木共之
  • Organizer: 第62回日本自律神経学会総会
  • Place of Presentation: 和歌山
  • Year and Date: 2009-11-06
• [Presentation] 視床下部による自律系の統合調節:オレキシンの役割 (2009)
  • Author(s): 桑木共之
  • Organizer: 第62回日本自律神経学会総会
  • Place of Presentation: 和歌山(シンポジウム招待講演)
  • Year and Date: 2009-11-05
• [Presentation] 睡眠と呼吸調節の脳内メカニズム:遺伝子工学を利用した最新の研究から (2009)
  • Author(s): 桑木共之
  • Organizer: 東洋大学第2回理工学シンポジュウム-脳科学と工学の融合-～脳の不思議を見るテクノロジー～
  • Place of Presentation: 埼玉(特別招待講演)
  • Year and Date: 2009-10-31
• [Presentation] 睡眠と呼吸調節の脳内メカニズム:遺伝子工学を利用した最新の研究から (2009)
  • Author(s): 桑木共之
  • Organizer: 東洋大学第2回理工学シンポジュウム
  • Place of Presentation: 埼玉
  • Year and Date: 2009-10-31
• [Presentation] Lack of stress-induced hyperthermia in orexin neuron-ablated mice (2009)
  • Author(s): 桑木共之, et al.
  • Organizer: Neuroscience2009
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-10-18
• [Presentation] Lack of stress-induced hyperthermia in orexin neuron-ablated mice. (2009)
  • Author(s): 桑木共之, 砂永仁子, 張薇, 桜井武
  • Organizer: Neuroscience Annual Meeting
  • Place of Presentation: Chicago USA
  • Year and Date: 2009-10-17
• [Presentation] ストレス時の発熱反応におけるオレキシン含有ニューロンの役割 (2009)
  • Author(s): 砂永仁子, 他
  • Organizer: 第32回日本神経科学学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-17
• [Presentation] Autonomic activity during emotional stress : role of orexin (2009)
  • Author(s): 桑木共之
  • Organizer: 第4回MCCS-Asia シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-15
• [Presentation] Orexinergic modulation of the autonomic activity during emotional stress. ISAN2009 Symposium. (2009)
  • Author(s): 桑木共之, 張薇, 砂永仁子, 桜井武
  • Organizer: Linking emotional stress to autonomic functions
  • Place of Presentation: Sydney Australia (Invited Symposiast)
  • Year and Date: 2009-09-04
• [Presentation] Orexinergic modulation of the autonomic activity during emotional stress (2009)
  • Author(s): 桑木共之, et al.
  • Organizer: 国際自律神経科学学会
  • Place of Presentation: Sydeny, Australia
  • Year and Date: 2009-09-03
• [Presentation] オレキシンニューロンによる褐色脂肪細胞支配の交感神経活動調節 (2009)
  • Author(s): 砂永仁子, 他
  • Organizer: 第7回交感神経とアンジオテンシンII研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-08-22
• [Presentation] Hypothalamic control of breathing (2009)
  • Author(s): 桑木共之
  • Organizer: 国際生理学会
  • Place of Presentation: 京都
  • Year and Date: 2009-07-28
• [Presentation] Hypothalamic control of breathing. (2009)
  • Author(s): 桑木共之
  • Organizer: 36th Congress of the International Union of the Physiological Sciences
  • Place of Presentation: Kyoto (Chair & Lecture in a Symposium)
  • Year and Date: 2009-07-27
• [Presentation] Hypothalamic modulation of breathing (2009)
  • Author(s): 桑木共之
  • Organizer: 11th Oxford Conference on Modeling and Control of breathing
  • Place of Presentation: 奈良
  • Year and Date: 2009-07-24
• [Presentation] Hypothalamic modulation of breathing. (2009)
  • Author(s): 桑木共之
  • Organizer: 11th Oxford Conference on Modeling and Control of breathing
  • Place of Presentation: Nara (Chair & Lecture in a Symposium)
  • Year and Date: 2009-07-23
• [Presentation] 神経性循環制御:an update. (2009)
  • Author(s): 桑木共之
  • Organizer: 日本循環制御医学会総会
  • Place of Presentation: 鹿児島(シンポジウム招待講演)
  • Year and Date: 2009-06-12
• [Presentation] 神経性循環制御:an update (2009)
  • Author(s): 桑木共之
  • Organizer: 日本循環制御医学会総会
  • Place of Presentation: 鹿児島
  • Year and Date: 2009-06-12
• [Presentation] Lack of handling stress-induced hyperthermia in orexin neuron-ablated mice (2009)
  • Author(s): 桑木共之, et al.
  • Organizer: Experimental Biology 2009
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2009-04-19
• [Presentation] Lack of handling stress-induced hyperthermia in orexin neuron-ablated mice. (2009)
  • Author(s): 桑木共之, 張薇, 桜井武
  • Organizer: Experimental Biology Meeting
  • Place of Presentation: New Orleans USA
  • Year and Date: 2009-04-18
• [Presentation] Orexin-containing neuron contributes stress-induced thermogenesis. (2009)
  • Author(s): Kuwaki T.
  • Organizer: 8th Japan-Korea Joint Symposium on Physiology
  • Place of Presentation: 釜山(韓国)
  • Year and Date: 2009-01-17
• [Presentation] Orexin-containing neuron contributes stress-induced thermogenesis. (2009)
  • Author(s): 桑木共之, 張薇
  • Organizer: 8th Japan-Korea Joint Symposium on Physiology
  • Place of Presentation: 釜山韓国(Invited Symposiast)
  • Year and Date: 2009-01-15
• [Presentation] ストレス誘発体温上昇におけるオレキシン含有神経の役割 (2008)
  • Author(s): 桑木共之
  • Organizer: 第36回自律神経生理研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-12-06
• [Presentation] 情動・行動に伴う自律制御のリセッティング (2008)
  • Author(s): 桑木共之
  • Organizer: 第3回SICE生物制御システム調査研究会
  • Place of Presentation: 東京(特別招待講演)
  • Year and Date: 2008-06-12
• [Book] Narcolepsy : Symptoms, Causes and Diagnosis and Treatment(Eds : Guillermo Santos & Lautar Villalba)(Autonomic malfunctions in mice model of narcolepsy.) (2010)
  • Author(s): Kuwaki T, Zhang W
  • Total Pages: 147
  • Publisher: Nova Science Publishers
• [Book] Narcolepsy : Symptoms, Causes and Diagnosis and Treatment. (2010)
  • Author(s): Kuwaki T, et al.
  • Publisher: Nova Science Publishers
• [Book] 睡眠学(呼吸器系と睡眠)(日本睡眠学会(編)) (2009)
  • Author(s): 桑木共之
  • Total Pages: 752
  • Publisher: 朝倉書店
• [Remarks] ホームページ等
  • URL: http://www.kufm.kagoshima-u.ac.jp/~physiol1/Research.html
• [Remarks]
  • URL: http://www.kufm.kagoshima-u.ac.jp/~physiol1/Research.html