Role of the orexin neurons in body temperature regulation
| Project/Area Number |
20590226
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
|
|---|
| Research Institution | Kagoshima University |
|---|
Principal Investigator |
KUWAKI Tomoyuki Kagoshima University, 医歯学総合研究科, 教授 (80205260)
|
|---|
| Research Collaborator |
ZHANG Wei 千葉大学, 医学研究院, 特任研究員
SUNANAGA Jinko 鹿児島大学, 医歯学総合研究科, 大学院生
TAKAHASHI Yoshiko 鹿児島大学, 医歯学総合研究科, 大学院生
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | オレキシン / 視床下部 / 体温調節 / ストレス / オレキシ / 発熱物質 / 低温環境 / 高温環境 |
|---|
| Research Abstract |
Possible role of orexin (hypocretin), a hypothalamic neuropeptide, in body temperature regulation was investigated using genetically engineered mice. Orexin containing neurons are indispensable for tress-induced thermogenesis although they minimally contribute to basal body temperature. Surprisingly, not orexin but co-transmitters contained in the orexin neurons are important for stress-induced thermogenesis.
|
Report
(4 results)
Research Products
(82 results)
