Anxiety is involved in tonic GABAergic inhibition in cerebral cortex and limbic system
| Project/Area Number |
20590229
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Hirosaki University |
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Principal Investigator |
YAMADA Junko 弘前大学, 大学院・医学研究科, 講師 (30334965)
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| Co-Investigator(Renkei-kenkyūsha) |
UENO Shinya 弘前大学, 大学院・医学研究科, 教授 (00312158)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | GABA / 抑制性シナプス伝達 / 不安 / ニューロン / トニックシグナル / 扁桃体 / tonic current / 卵巣切除 / スライスパッチクランプ / ステロイドホルモン / PRIP-1ノックアウトマウス / トニック / ホルモン |
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| Research Abstract |
PRIP1, a novel IP3 binding protein, functioned as a transporter protein of GABAA receptor to plasma membrane. Then PRIP1-KO mice should be changed the GABAergic inhibitory system. KO mice showed decreasing motor activity by an open-field test. Using brain slices and whole-cell patch-clamp recordings, there are no significant difference both amplitude and frequency of mEPSCs and mIPSCS between WT and KO mice. Tonic GABAergic inhibition exist in principal neurons of the basolateral amygdala in WT mice but PRIP-1 KO mice have imperfection of this inhibitory system.
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Report
(4 results)
Research Products
(20 results)
