Mechanisms of inhibitory effects of estrogens on psychological stress-induced pressor response via suppression of oxidative stress

• Project/Area Number: 20590230
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Nara Women's University
• Principal Investigator: MORIMOTO Keiko Nara Women's University, 生活環境学部, 教授 (30220081)
• Co-Investigator(Kenkyū-buntansha): TAKAMATA Akira 奈良女子大学, 生活環境学部, 教授 (00264755) ; UEYAMA Takashi 和歌山県立医科大学, 医学部, 准教授 (50264875) ; KIMURA Hiroko 順天堂大学, 医学部, 准教授 (00053299) ; YOSHIDA KenーIchi 東京大学, 大学院・医学系研究科, 教授 (40166947)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 精神性ストレス / エストロゲン / 閉経後女性 / 閉経モデルラット / 酸化ストレス / 血圧調節 / 血管収縮反応 / 一酸化窒素 / 性差

Research Abstract

The findings of experiments with volunteers or ovariectomized rats suggested that the menopause enhanced forearm vascular resistance to mental stress, and estrogen replacement attenuated pressor responses through its anti-oxidative activity.

Research Products

• [Journal Article] Chronic oestrogen replacement in ovariectomized rats attenuates food intake and augments c-Fos expression in the suprachiasmatic nucleus specifically during the light phase. (2011)
  • Author(s): Akira Takamata, Kayo Torii, Kana Miyake, Keiko Morimoto
  • Journal Title: British Journal of Nutrition in press
  • Peer Reviewed
• [Journal Article] Chronic oestrogen replacement in ovariectomized rats attenuates food intake and augments c-Fos expression in the suprachiasmatic nucleus specifically during the light phase (2011)
  • Author(s): Akira Takamata, Kayo Torii, Kana Miyake, Keiko Morimoto
  • Journal Title: British Journal of Nutrition Volume: (in press)
  • Peer Reviewed
• [Journal Article] 精神性ストレス時の循環反応に対するエストロゲンの抑制作用と酸化ストレスの関与 (2010)
  • Author(s): 森本恵子, 上山敬司
  • Journal Title: 自律神経(総説) 47(4) Pages: 321-327
  • NAID: 10026905970
• [Journal Article] 精神性ストレス時の循環反応に対するエストロゲンの抑制作用と酸化ストレスの関与(総説) (2010)
  • Author(s): 森本恵子、上山敬司
  • Journal Title: 自律神経 Volume: 47 Pages: 321-327
• [Journal Article] Plasma hyperosmolality elevates the internal temperature threshold for active thermoregulatory vasodilation during heat stress in humans. (2009)
  • Author(s): Shibasaki M, Aoki K, Morimoto K, Johnson JM, Takamata A.
  • Journal Title: Am J Physiol Regul Integr Comp Physiol 297(6)
  • Peer Reviewed
• [Journal Article] Plasma hyperosmolality elevates the internal temperature threshold for active thermoregulatory vasodilation during heat stress in humans. (2009)
  • Author(s): Shibasaki M, Aoki K, Morimoto K, Johnson JM.Takamata A
  • Journal Title: Am J Physiol Regul Integr Comp Physiol. 297(6)
  • Peer Reviewed
• [Journal Article] Effects of estrogen on stress-induced activation of peptide neurons in PVN in ovariectomized rat. (2008)
  • Author(s): Hara Y, Kohno T, Takamata A, Ueyama T, Morimoto K
  • Journal Title: Ann NY Acad Sci 1148 Pages: 99-105
  • Peer Reviewed
• [Journal Article] Mental stress induces sustained elevation of blood pressure and lipid peroxidation in postmenopausal women. (2008)
  • Author(s): Morimoto K, Morikawa M, Kimura H, Ishii N, Takamata A, Hara Y, Uji M, Yoshida K.
  • Journal Title: Life Sci 82(1-2) Pages: 92-107
  • Peer Reviewed
• [Journal Article] Estrogen replacement suppresses pressor response and oxidative stress induced by cage-switch stress in ovariectomized rats. (2008)
  • Author(s): Morimoto K, Uji M, Ueyama T, Kimura H, Kohno T, Takamata A, Yano S, Yoshida K.
  • Journal Title: Ann NY Acad Sci 1148 Pages: 213-218
  • Peer Reviewed
• [Journal Article] 女子大生の食行動と情動知能(EQ)との関係について-食行動とEQの専攻別比較- (2008)
  • Author(s): 本多恭子, 森本恵子
  • Journal Title: 家政学研究 55(1) Pages: 1-7
  • Peer Reviewed
• [Journal Article] 女子大学生の食行動調査表のカテゴリー別得点と情動知能尺度(EQS)との相関性について (2008)
  • Author(s): 本多恭子, 森本恵子, 朝山正巳
  • Journal Title: 肥満学研究 14(1) Pages: 49-56
  • Peer Reviewed
• [Journal Article] Mental stress induces sustained elevation of blood pressure and lipid peroxidation in postmenopausal women. (2008)
  • Author(s): Keiko Morimoto
  • Journal Title: Life Sciences 82 Pages: 92-107
  • Peer Reviewed
• [Journal Article] Estrogen replacement suppresses pressor response and oxidative stressinduced by cage-switch stress in ovariectomized rats. (2008)
  • Author(s): Keiko Morimoto
  • Journal Title: Annals of the New York Academy of Sciences 1148 Pages: 213-218
  • Peer Reviewed
• [Journal Article] Effects of estrogen on stress-induced activation of peptide neurons in PVN in ovariectomized rat. (2008)
  • Author(s): Yasuko Hara
  • Journal Title: Annals of the New York Academy of Sciences 1148 Pages: 99-105
  • Peer Reviewed
• [Presentation] Estrogen replacement supresses stress-induced pressor response through angiotensin II-dependent mechanism in ovariectomized rats. (2011)
  • Author(s): Shoko Tazumi, HsiaoYun Lin, Teiko Koyama, Akira Takamata, Keiko Morimoto
  • Organizer: 第88回日本生理学会大会
  • Place of Presentation: 震災のため誌上開催
  • Year and Date: 2011-03-29
• [Presentation] Effects of estrogen replacement on high fat diet-induced obesity in ovariectomized rats. (2011)
  • Author(s): Hsiao Yun Lin, Shoko Tazumi, Yuka Hirose, Akira Takamata, Keiko Morimoto
  • Organizer: 第88回日本生理学会大会
  • Place of Presentation: 震災のため誌上開催
  • Year and Date: 2011-03-29
• [Presentation] Estrogen replacement supresses stress-induced pressor response through angiotensin II-dependent mechanism in ovariectomized rats (2011)
  • Author(s): Shoko Tazumi, HsiaoYun Lin, Teiko Koyama, Akira Takamata, Keiko Morimoto
  • Organizer: 第88回日本生理学会大会
  • Place of Presentation: (震災のため誌上開催)
  • Year and Date: 2011-03-29
• [Presentation] Effects of estrogen replacement on high fat diet-induced obesity in ovariectomized rats (2011)
  • Author(s): HsiaoYun Lin, Shoko Tazumi, Yuka Hirose, Akira Takamata, Keiko Morimoto
  • Organizer: 第88回日本生理学会大会
  • Place of Presentation: (震災のため誌上開催)
  • Year and Date: 2011-03-29
• [Presentation] c-Fos expression in the orexin A and melanin cocentrating hormone neurons in the lateral hypothalamic area and food intake responses to reduced glucose availability. (2011)
  • Author(s): Akira Takamata, Sayumi Taguchi, Saori Ikeda, Eri Aida, Keiko Morimoto
  • Organizer: 第88回日本生理学会大会
  • Place of Presentation: 震災のため誌上開催
  • Year and Date: 2011-03-21
• [Presentation] c-Fos expression in the orexin A and melanin cocentrating hormone neurons in the lateral hypothalamic area and food intake responses to reduced glucose availability (2011)
  • Author(s): Akira Takamata, Sayumi Taguchi, Saori Ikeda, Eri Aida, Keiko Morimoto
  • Organizer: 第88回日本生理学会大会
  • Place of Presentation: (震災のため誌上開催)
  • Year and Date: 2011-03-21
• [Presentation] Roles of oxidative stress on the reduction of forearm blood flow induced by mental stress in postmenopausal women (2010)
  • Author(s): Keiko Morimoto, Kozue Ohyama, Mai Motohiro, Shigenobu Yano, Akira Takamata
  • Organizer: 第87回日本生理学会大会
  • Place of Presentation: 盛岡市
  • Year and Date: 2010-05-21
• [Presentation] Roles of oxidative stress on the reduction of forearm blood flow induced by mental stress in postmenopausal women. (2010)
  • Author(s): Keiko Morimoto, Kozue Ohyama, Mai Motohiro, Shigenobu Yano, Akira Takamata
  • Organizer: 第87回日本生理学会大会,シンポジウム,Molecular mechanisms for the regulation of vascular tone and its abnormalities
  • Place of Presentation: 盛岡市
  • Year and Date: 2010-05-19
• [Presentation] Estrogen attenuates food intake and hypothalamic c-Fos expression in response to reduced glucose availability during light phase. (2010)
  • Author(s): Akira Takamata, Kana Miyake, Kotomi Ueda, Mami Miyake, Megumu Hasegawa, Yuko Nakamura, Yoko Fujita, 森本恵子
  • Organizer: 第87回日本生理学会大会
  • Place of Presentation: 盛岡市
  • Year and Date: 2010-05-19
• [Presentation] Estrogen attenuates food intake and hypothalamic c-Fos expression in response to reduced glucose availability during light phase (2010)
  • Author(s): Akira Takamata, Kana Miyake, Kotomi Ueda, Mami Miyake, Megumu Hasegawa, Yuko Nakamura, Yoko Fujita, Keiko Morimoto
  • Organizer: 第87回日本生理学会大会
  • Place of Presentation: 盛岡市
  • Year and Date: 2010-05-19
• [Presentation] 精神性ストレス時の循環反応に対するエストロゲンの抑制作用と酸化ストレスの関与 (2009)
  • Author(s): 森本恵子
  • Organizer: 第62回日本自律神経学会総会シンポジウム「循環調節異常における酸化ストレスの役割」
  • Place of Presentation: 和歌山市(国内招待講演)
  • Year and Date: 2009-11-06
• [Presentation] シンポジウム「循環調節異常における酸化ストレスの役割」:精神性ストレス時の循環反応に対するエストロゲンの抑制作用と酸化ストレスの閏与 (2009)
  • Author(s): 森本恵子、池畑あい、鷹股亮、木村博子、吉田謙一
  • Organizer: 第62回日本自律神経学会総会
  • Place of Presentation: 和歌山
  • Year and Date: 2009-11-06
• [Presentation] 中年女性における精神性ストレスによる末梢血管反応に対する閉経の影響 (2009)
  • Author(s): 森本恵子, 大山こず江, 鷹股亮
  • Organizer: 日本家政学会第61回大会
  • Place of Presentation: 武庫川女子大
  • Year and Date: 2009-08-31
• [Presentation] 卵巣摘出ラットにおけるインスリン抵抗性及びインスリン情報伝達経路に対するエストロゲン補充の影響 (2009)
  • Author(s): 河上瑞穂, 池畑あい, 森本恵子
  • Organizer: 日本家政学会第61回大会
  • Place of Presentation: 武庫川女子大
  • Year and Date: 2009-08-31
• [Presentation] 精神性ストレスによる循環反応の性差及びエストロゲンの作用 (2009)
  • Author(s): 森本恵子
  • Organizer: 日本心理学会第73回大会ワークショップ「男のこころ、女のこころ-その生物学的基盤」
  • Place of Presentation: 京都市(国内招待講演)
  • Year and Date: 2009-08-26
• [Presentation] ワークショップ「男のこころ、女のこころ-その生物学的基盤」:精神性ストレスによる循環反応の性差及びエストロゲンの作用 (2009)
  • Author(s): 森本恵子
  • Organizer: 日本心理学会第73回大会
  • Place of Presentation: 立命館大学
  • Year and Date: 2009-08-26
• [Presentation] Effects of estrogen replacement on oxidative stress in vasculature related to psychological stress in ovariectomized rats. (2009)
  • Author(s): Ai Ikehata, Mizuho Kawakami, Sumire Ohkawa, Asumi Yoshida, Masami Uji, Akira Takamata, Ken-ichi Yoshida, Keiko Morimoto
  • Organizer: 36^<th> International Congress of Physiological Sciences
  • Place of Presentation: Kyoto
  • Year and Date: 2009-08-01
• [Presentation] Effects of estrogen replacement on oxidative stress in vasculature related to psychological stress in ovariectomized rats (2009)
  • Author(s): Ai Ikehata ; Mizuho Kawakami ; Sumire Ohkawa ; Asumi Yoshida ; Masami Uji ; Akira Takamata ; Ken-ichi Yoshida ; Keiko Morimoto
  • Organizer: 36^<th> International Congress of Physiological Sciences
  • Place of Presentation: Kyoto
  • Year and Date: 2009-08-01
• [Presentation] Effects of estrogen replacement on insulin resistance in ovariectomized rats. (2009)
  • Author(s): Mizuho Kawakami, Ai Ikehata, Marie Ro, Masami Uji, Ken-ichi Yoshida, Keiko Morimot
  • Organizer: 36^<th> International Congress of Physiological Sciences
  • Place of Presentation: Kyoto
  • Year and Date: 2009-07-30
• [Presentation] Effects of estrogen on stress-induced activation of nitric oxideproducing neurons in paraventricular hypothalamic nucleus of rats. (2009)
  • Author(s): Keiko Morimoto, Tomoko Hata, Yurina Omuro, Yasuko Hara, Akira Takamata, Takashi Ueyama.
  • Organizer: 36^<th> International Congress of Physiological Sciences
  • Place of Presentation: Kyoto
  • Year and Date: 2009-07-30
• [Presentation] Effects of estrogen replacement on insulin resistance in ovariectomized rats (2009)
  • Author(s): Mizuho Kawakami, Ai Ikehata, Marie Ro, Masami Uji, Ken-ichi Yoshida, Keiko Morimoto
  • Organizer: 36^<th> International Congress of Physiological Sciences
  • Place of Presentation: Kyoto
  • Year and Date: 2009-07-30
• [Presentation] Effects of estrogen on stress-induced activation of nitric oxide-producing neurons in paraventricular hypothalamic nucleus of rats (2009)
  • Author(s): Keiko Morimoto, Tomoko Hata, Yurina Omuro, Yasuko Hara, Akira Takamata, Takashi Ueyama
  • Organizer: 36^<th> International Congress of Physiological Sciences
  • Place of Presentation: Kyoto
  • Year and Date: 2009-07-30
• [Book] ストレス科学辞典 (2011)
  • Author(s): 森本恵子, 他
  • Total Pages: 1137
  • Publisher: 日本ストレス学会
• [Remarks] ホームページ等
  • URL: http://www.nara-wu.ac.jp/life/health/morimoto/index.html
• [Remarks]
  • URL: http://www.nara-wu.ac.jp/life/health/morimoto/index.html