Molecular basis of the rhythmical expression of the genes in the gastrointestinal tract
| Project/Area Number |
20590233
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | University of Shizuoka |
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Principal Investigator |
GODA Toshinao University of Shizuoka, 食品栄養科学部, 教授 (70195923)
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| Co-Investigator(Kenkyū-buntansha) |
MOCHIZUKI Kazuki 静岡県立大学, 食品栄養科学部, 助教 (80423838)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 時計遺伝子 / 小腸 / 日内リズム / 転写調節 / マイクロアレイ / 糖輸送担体 |
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| Research Abstract |
Restricted feeding schedule led to a shift of the peak of the expression of clock gene (per 2) and a hexose transporter gene (sglt1) to just prior to the start of feeding. The binding of BMAL1 and acetylated histone H3 and H4 to the transcribed regions of these genes was associated with changes in their expressions. These results suggest that diurnal changes in expression of hexose transporter genes are regulated by a feedback loop of clock genes.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Histone H3 methylation at lysine 4 on the SLC2A5 gene in intestinal Caco-2 cells is involved in SLC2A5 expression.2010
Author(s)
Inamochi, Y., Mochizuki, K., Osaki, A., Ishii, T., Nakayama, T., Goda, T.
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Journal Title
Biochem.Biophys.Res.Commu. Vol.392
Pages: 16-21
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