Roles of the PrRP-oxytocin pathway in the control of stress and social behaviour
Project/Area Number |
20590237
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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Research Institution | Jichi Medical University |
Principal Investigator |
ONAKA Tatsushi Jichi Medical University, 医学部, 教授 (90177254)
|
Co-Investigator(Renkei-kenkyūsha) |
TAKAYANAGI Yuki 自治医科大学, 医学部, 助教 (10418890)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | オキシトン / PrRP / 不安行動 / 社会記憶 / セロトニン / バゾプレシ / オキシトシン / 摂食 / CCK / 視索上核 / ストレス / 視床下部 / 視床下部背北側核 / Fosタンパク質 / 酸素消費量 / 弧束路核 |
Research Abstract |
Not only stressful stimuli but also food intake activated PrRP-synthesizing neurons and oxytocin-synthesizing neurons. Social stimuli activated oxytocin-synthesizing neurons. PrRP-synthesizing neurons were suggested to have stress-modulating and anorexic actions. Oxytocin-synthesizing neurons were suggested to have anti-stress, anorexic and social memory-enhancing actions. Downstream neurons of oxytocin-synthesizing neurons were suggested to be serotoninergic.
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Report
(4 results)
Research Products
(55 results)
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[Journal Article] An intrinsic vasopressin system in the olfactory bulb is involved in social recognition.2010
Author(s)
Tobin VA, Hashimoto H, Wacker DW, Takayanagi Y, Langnaese K, Caquineau C, Noack J, Landgraf R, Onaka T, Leng G, Meddle SL, Engelmann M, Ludwig M
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Journal Title
Nature 464(7287)
Pages: 413-417
Related Report
Peer Reviewed
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