Roles of the PrRP-oxytocin pathway in the control of stress and social behaviour

• Project/Area Number: 20590237
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Jichi Medical University
• Principal Investigator: ONAKA Tatsushi Jichi Medical University, 医学部, 教授 (90177254)
• Co-Investigator(Renkei-kenkyūsha): TAKAYANAGI Yuki 自治医科大学, 医学部, 助教 (10418890)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: オキシトン / PrRP / 不安行動 / 社会記憶 / セロトニン / バゾプレシ / オキシトシン / 摂食 / CCK / 視索上核 / ストレス / 視床下部 / 視床下部背北側核 / Fosタンパク質 / 酸素消費量 / 弧束路核

Research Abstract

Not only stressful stimuli but also food intake activated PrRP-synthesizing neurons and oxytocin-synthesizing neurons. Social stimuli activated oxytocin-synthesizing neurons. PrRP-synthesizing neurons were suggested to have stress-modulating and anorexic actions. Oxytocin-synthesizing neurons were suggested to have anti-stress, anorexic and social memory-enhancing actions. Downstream neurons of oxytocin-synthesizing neurons were suggested to be serotoninergic.

Research Products

• [Journal Article] Effects of RFamide-related peptide (RFRP)-1 and RFRP-3 on oxytocin release and anxiety-related behaviour in rats. (2011)
  • Author(s): Kaewwongse M, Takayanagi Y, Onaka T
  • Journal Title: J Neuroendocrinol 23(1) Pages: 20-27
  • Peer Reviewed
• [Journal Article] Effects of RFamide-related peptide (RFRP)-1 and RFRP-3 on oxytocin release and anxiety-related behaviour in rats. (2011)
  • Author(s): Kaewwongse, M.
  • Journal Title: J Neuroendocrinol Volume: 23 Pages: 20-27
  • Peer Reviewed
• [Journal Article] An intrinsic vasopressin system in the olfactory bulb is involved in social recognition. (2010)
  • Author(s): Tobin VA, Hashimoto H, Wacker DW, Takayanagi Y, Langnaese K, Caquineau C, Noack J, Landgraf R, Onaka T, Leng G, Meddle SL, Engelmann M, Ludwig M
  • Journal Title: Nature 464(7287) Pages: 413-417
  • Peer Reviewed
• [Journal Article] Participation of the prolactin-releasing peptide-containing neurons in caudal medulla in conveying hemorrhagic stress-induced signals to the paraventricular nucleus of the hypothalamus. (2010)
  • Author(s): Uchida K, Kobayashi D, Das G, Onaka T, Inoue K, Itoi K
  • Journal Title: J Neuroendocrinol 22(1) Pages: 33-42
  • Peer Reviewed
• [Journal Article] Roles of prolactin-releasing peptide and RFamide related peptides in the control of stress and food intake. (2010)
  • Author(s): Takayanagi Y, Onaka T
  • Journal Title: FEBS J 277(24) Pages: 4998-5005
  • Peer Reviewed
• [Journal Article] Metabolic and stress-related roles of prolactin-releasing peptide. (2010)
  • Author(s): Onaka T, Takayanagi Y, Leng G
  • Journal Title: Trends Endocrinol Metab 21(5) Pages: 287-293
  • Peer Reviewed
• [Journal Article] Stressor-responsive central nesfatin-1 activates corticotropin-releasing hormone, noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal axis. (2010)
  • Author(s): Yoshida, N.
  • Journal Title: Aging Volume: 2 Pages: 775-784
  • Peer Reviewed
• [Journal Article] Long-term infusion of brain-derived neurotrophic factor reduces food intake and body weight via a corticotropin releasing hormone pathway in the paraventricular nucleus of the hypothalamus. (2010)
  • Author(s): Toriya, M.
  • Journal Title: J Neuroendocrinol Volume: 22 Pages: 987-995
  • Peer Reviewed
• [Journal Article] Roles of prolactin-releasing peptide and RFamide related peptides in the control of stress and food intake. (2010)
  • Author(s): Takayanagi, Y.
  • Journal Title: FEBS J Volume: 227 Pages: 4998-5005
  • Peer Reviewed
• [Journal Article] Metabolic and stress-related roles of prolactin-releasing peptide. (2010)
  • Author(s): Onaka, T.
  • Journal Title: Trends Endocrinol Metab. Volume: 21 Pages: 287-293
  • Peer Reviewed
• [Journal Article] Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice. (2009)
  • Author(s): Yoshida M, Takayanagi Y, Inoue K, Kimura T, Young L, Onaka T, Nishimori K
  • Journal Title: J Neurosci 29(7) Pages: 2259-2271
  • Peer Reviewed
• [Journal Article] Dog's gaze at its owner increases owner's urinary oxytocin during social interaction. (2009)
  • Author(s): Nagasawa M, Kikusui T, Onaka T, Ohta M
  • Journal Title: Horm Behav 55(3) Pages: 434-441
  • Peer Reviewed
• [Journal Article] 脳内ホルモンと行動-オキシトシンとバゾプレシンの働き (2009)
  • Author(s): 尾仲達史
  • Journal Title: 日本抗加齢医学会雑誌 5 Pages: 47-53
• [Journal Article] Dog's gaze at its owner increases owner's urinary oxytocin during social interaction (2009)
  • Author(s): Nagasawa M
  • Journal Title: Hormones and behavior 55 Pages: 434-41
  • Peer Reviewed
• [Journal Article] Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice (2009)
  • Author(s): Yoshida M
  • Journal Title: Journal of Neuroscience 29 Pages: 2259-71
  • Peer Reviewed
• [Journal Article] Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice. (2009)
  • Author(s): Yoshida, M.
  • Journal Title: J Neurosci 29 Pages: 2259-2271
  • Peer Reviewed
• [Journal Article] Dog's Gaze at its Owner Increases Owner's Urinary Oxytocin During Social Interaction. (2009)
  • Author(s): Nagasawa, M.
  • Journal Title: Horm Behav 55 Pages: 434-441
  • Peer Reviewed
• [Journal Article] Endogenous prolactin-releasing peptide regulates food intake in rodents. (2008)
  • Author(s): Takayanagi Y, Matsumoto H, Nakata M, Mera T, Fukusumi S, Hinuma S, Ueta Y, Yada T, Leng G, Onaka T
  • Journal Title: J Clinical Invest 118(12) Pages: 4014-4024
  • Peer Reviewed
• [Journal Article] Oxytocin receptor-deficient mice developed late-onset obesity. (2008)
  • Author(s): Takayanagi Y, Kasahara Y, Onaka T, Takahashi N, Kawada T, Nishimori K
  • Journal Title: NeuroReport 19(9) Pages: 951-955
  • Peer Reviewed
• [Journal Article] Oxytocin and appetite. (2008)
  • Author(s): Leng G, Onaka T, Caquineau C, Sabatier N, Tobin VA, Takayanagi Y
  • Journal Title: Prog Brain Res. 170 Pages: 137-151
• [Journal Article] Endogenous prolactin-releasing peptide regulates food intake in rodents. (2008)
  • Author(s): Takayanagi, Y.
  • Journal Title: J Clinical Invest 118 Pages: 4014-4024
  • Peer Reviewed
• [Journal Article] The single-prolonged stress paradigm alters both the morphology and stress response of magnocellular vasopressin neurons. (2008)
  • Author(s): Yoshii, T.
  • Journal Title: Neuroscience 156 Pages: 446-474
  • Peer Reviewed
• [Journal Article] Leptin inhibits and ghreline augments hypothalamic noradrenaline release after stress. (2008)
  • Author(s): Kawakami, A.
  • Journal Title: Stress 11 Pages: 363-369
  • Peer Reviewed
• [Journal Article] Oxytocin receptor-deficient mice developed late-onset obesity (2008)
  • Author(s): Takayanagi, Y.
  • Journal Title: NeuroRevort 19 Pages: 951-955
  • Peer Reviewed
• [Journal Article] Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding (2008)
  • Author(s): Kohno, D.
  • Journal Title: Endocrinology 149 Pages: 1295-1301
  • Peer Reviewed
• [Journal Article] Oxytocin receptor-deficient mice developed late-onset obesity. (2008)
  • Author(s): Takayanagi, Y.
  • Journal Title: NeuroReport 19 Pages: 951-955
  • Peer Reviewed
• [Journal Article] Oxytocin and appetite. (2008)
  • Author(s): Leng, G.
  • Journal Title: Prog Brain Res 170 Pages: 137-151
  • Peer Reviewed
• [Journal Article] Metabolic and stress-related roles of prolactin-releasing peptide
  • Author(s): 尾仲達史
  • Journal Title: Trends in Endocrinology and Metabolism (In press)
  • Peer Reviewed
• [Presentation] ストレス反応と下垂体後葉ホルモン (2011)
  • Author(s): 尾仲達史
  • Organizer: 第22回日本臨床モニター学会総会
  • Place of Presentation: (誌上開催)
  • Year and Date: 2011-04-22
• [Presentation] Roles of PrRP in the control of energy metabolisms and stress responses. (2011)
  • Author(s): Takayanagi, Y.
  • Organizer: 第88回日本生理学会大会
  • Place of Presentation: (誌上開催)
  • Year and Date: 2011-03-29
• [Presentation] Participation of the Prolactin-Releasing Peptide-Containing Neurones in Caudal Medulla in Conveying Haemorrhagic Stress-Induced Signals to the Paraventricular Nucleus of the Hypothalamus. (2010)
  • Author(s): Uchida, Y.
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸コンベンションセンター
  • Year and Date: 2010-09-03
• [Presentation] Effects of Rfamide related peptides upon oxytocin release in rats. (2010)
  • Author(s): Takayanagi Y, Kaewwongse M, Onaka T
  • Organizer: The 7^<th> International Congress Neuroendocrinology (ICN2010)
  • Place of Presentation: Rouen, France
  • Year and Date: 2010-07-14
• [Presentation] Effects of Rfamide related peptides upon oxytocin release in rats. (2010)
  • Author(s): Takayanagi, Y.
  • Organizer: The 7^<th> International Congress Neuroendocrinology(ICN2010)
  • Place of Presentation: Rouen, France
  • Year and Date: 2010-07-14
• [Presentation] Neurohypophyseal hormones and stress responses or social behavior : analysis with the use of specific destruction of vasopressin neurons. (2010)
  • Author(s): Takayanagi Y, Onaka T
  • Organizer: The 87^<th> Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Morioka
  • Year and Date: 2010-05-20
• [Presentation] Roles of secretin and oxytocin in social recognition in mice. (2010)
  • Author(s): Takashima A, Takayanagi Y, Saito M, Yamagata T, Momoi M, Onaka T
  • Organizer: The 87^<th> Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Morioka
  • Year and Date: 2010-05-20
• [Presentation] Roles of vasopressin and oxytocin in the control of emotion and social behavior. (2010)
  • Author(s): Onaka T, Takayanagi Y
  • Organizer: The 88^<th> Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Yokohama
  • Year and Date: 2010-03-30
• [Presentation] Effects of i.c.v. administration of RFamide related peptide-1 upon release of stress-related hormones and anxiety-related behavior. (2010)
  • Author(s): Kaewwongse M, Takayanagi Y, Onaka T
  • Organizer: 14^<th> International Congress of Endocrinology (ICE2010)
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-03-30
• [Presentation] Roles of PrRP and oxytocin receptor in stress-induced increase of energy expenditure. (2010)
  • Author(s): Takayanagi Y, Nishimori K, Onaka T
  • Organizer: 14^<th> International Congress of Endocrinology (ICE2010)
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-03-30
• [Presentation] Effects of i.c.v.administration of RFamide related peptide-1 upon release of stress-related hormones and anxiety-related behavior (2010)
  • Author(s): Kaewwongse M
  • Organizer: 14^<th> International Congress of Endocrinology(ICE2010)
  • Place of Presentation: 国立京都国際会館、京都
  • Year and Date: 2010-03-30
• [Presentation] Roles of PrRP and oxytocin receptor in stress-induced increase of energy expenditure (2010)
  • Author(s): Takayanagi Y
  • Organizer: 14^<th> International Congress of Endocrinology(ICE2010)
  • Place of Presentation: 国立京都国際会館、京都
  • Year and Date: 2010-03-30
• [Presentation] Roles of PrRP in the control of energy metabolisms and stress responses. (2010)
  • Author(s): Takayanagi Y, Onaka T
  • Organizer: The 88^<th> Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Yokohama
  • Year and Date: 2010-03-29
• [Presentation] Secretin facilitates social behaviors via activation of oxytocin receptors. (2010)
  • Author(s): Takayanagi Y, Takashima A, Onaka T
  • Organizer: The 33^<rd> Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Kobe
• [Presentation] Role of prolactin-releasing peptide in stress-induced energy expenditure. (2009)
  • Author(s): Takayanagi Y, Onaka T
  • Organizer: The 32^<nd> Annual Meeting of the Japan Neuroscience Society.
  • Place of Presentation: Nagoya
  • Year and Date: 2009-09-18
• [Presentation] Effects of i.c.v.administration of RFamide related peptide-1 upon release of stress-related hormones and anxiety-related behavior (2009)
  • Author(s): Kaewwongse M
  • Organizer: 8th World Congress on Neurohypophysial Hormones(WCNH2009)
  • Place of Presentation: 北九州国際会議場、北九州市
  • Year and Date: 2009-09-04
• [Presentation] Role of oxytocin receptors in the control of stress-induced energy expenditure (2009)
  • Author(s): Takayanagi Y
  • Organizer: 8th World Congress on Neurohypophysial Hormones(WCNH2009)
  • Place of Presentation: 北九州国際会議場、北九州市
  • Year and Date: 2009-09-04
• [Presentation] Prolactin-releasing peptide is impotant for relaying leptin signaling to reduce food intake and body weight. (2009)
  • Author(s): Takayanagi Y, Onaka T
  • Organizer: The 36^<th> International Congress of Physiological Sciences (IUPS2009)
  • Place of Presentation: Kyoto
  • Year and Date: 2009-07-30
• [Presentation] Effects of i.c.v. administration of RFamide related peptides on plasma oxytocin concentrations in rats. (2009)
  • Author(s): Kaewwongse M, Takayanagi Y, Onaka T
  • Organizer: The 36^<th> International Congress of Physiological Sciences (IUPS2009)
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2009-07-28
• [Presentation] Effects of i.c.v.administration of RFamide related peptides on plasma oxytocin concentrations in rats (2009)
  • Author(s): Kaewwongse M
  • Organizer: The 36th International Congress of Physiological Sciences(IUPS2009)
  • Place of Presentation: 国立京都国際会館、京都
  • Year and Date: 2009-07-28
• [Presentation] Oxygen consumption in prolactin-releasing peptide-deficient mice during stressful stimuli. (2009)
  • Author(s): Onaka T, Takayanagi Y
  • Organizer: British Society for Neuroendocrinology Annual Meeting 2009 (BSN2009)
  • Place of Presentation: Edinburgh, UK
  • Year and Date: 2009-06-29
• [Presentation] 摂食とエネルギー代謝におけるプロラクチン放出ペプチドの働き. (2008)
  • Author(s): 高柳友紀
  • Organizer: 第36回自律神経生理研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-12-06
• [Presentation] ストレスと摂食. (2008)
  • Author(s): 尾仲達史
  • Organizer: 第7回行動神経内分泌研究会
  • Place of Presentation: 御殿場
  • Year and Date: 2008-07-26
• [Presentation] Role of prolactin-releasing peptide in the control of energy expenditure. (2008)
  • Author(s): Takayanagi Y, Onaka T
  • Organizer: The 31^<st> Annual Meeting of the Japan Neuroscience Society, Neuroscience 2008
  • Place of Presentation: Tokyo
  • Year and Date: 2008-07-10
• [Presentation] ストレスと摂食. (2008)
  • Author(s): 尾仲達史
  • Organizer: 第10回産業生理セミナー
  • Place of Presentation: 北九州
  • Year and Date: 2008-06-21
• [Presentation] Interaction between food intake and stress : roles of endogenous prolactin-releasing peptide. (2008)
  • Author(s): Onaka, T.
  • Organizer: Japan/China Symposium 2008
  • Place of Presentation: Tsukuba
• [Presentation] エネルギー消費におけるPrRPの役割. (2008)
  • Author(s): 高柳友紀
  • Organizer: 第31回日本神経科学大会(Neuroscience 2008)
  • Place of Presentation: 東京