Sex steroids and the sexually dimorphic nucleus of the rat preoptic area

• Project/Area Number: 20590238
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Nippon Medical School
• Principal Investigator: ORIKASA Chiotse Nippon Medical School, 医学部, 講師 (20270671)
• Co-Investigator(Kenkyū-buntansha): SAKUMA Yasuo 日本医科大学, 大学院・医学研究科, 教授 (70094307) ; HAMADA Tomohiro 日本医科大学, 医学部, 助教 (90312058)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 性差 / エストロゲン / 神経細胞移動 / 脳・神経 / 細胞死 / 脳 / 性差形成 / ステロイド / SDN-POA / BrdU / カルビンジン

Research Abstract

Although the SDN-POA was significantly larger in males than in females at PD15, the total numbers of neurons comprising the SDN-POA were not significantly different between sexes. Sexual dimorphism in the SDN-POA results from male-specific postnatal radial spreading of cells rather than cell proliferation during embryonic neurogenesis.

Research Products

• [Journal Article] Estrogen configures the sexual dimorphism in the preoptic area of C57BL/6J and ddN strains of mice (2010)
  • Author(s): Orikasa C, Sakuma Y
  • Journal Title: The Journal of Comparative Neurology vol. 518 Pages: 3618-3629
  • Peer Reviewed
• [Journal Article] Similar numbers of neurons are generated inthe male and female rat preoptic area in utero (2010)
  • Author(s): Orikasa C, Kondo, Y., Usui, S., Sakuma Y
  • Journal Title: Neuroscience Research vol. 68 Pages: 9-144
  • Peer Reviewed
• [Journal Article] Alternative promoter usage and alternative splicing of therat estrogen receptor gene generate numerous mRNA variants with distinct 5'-ends. (2010)
  • Author(s): Ishii H, Kobayashi M, Sakuma Y
  • Journal Title: JournalSteroid Biochemistry and Molecular Bioligy 118(1/2) Pages: 59-69
  • Peer Reviewed
• [Journal Article] Estrogen receptor α gene promoter 0/B usage in the rat sexually dimorphic nucleus of the preoptic area. (2010)
  • Author(s): Hamada T, Sakuma Y
  • Journal Title: Endocrinology 151(4) Pages: 1923-1928
  • Peer Reviewed
• [Journal Article] Similar numbers of neurons are generated in the male and femalerat preoptic area in utero (2010)
  • Author(s): Orikasa C., Kondo, Y., Usui, S., Sakuma Y.
  • Journal Title: Neuroscience Research Volume: 68 Pages: 9-14
  • Peer Reviewed
• [Journal Article] (2010)
  • Author(s): Chitose Orikasa, Yasuo Sakuma
  • Journal Title: Journal Comparative Neurology Volume: 518 Pages: 3618-3629
  • Peer Reviewed
• [Journal Article] Sex steroids and the establishment of the sexually dimorphic nuclus of the preopticarea, How Are Neuroendocrine Hypothalamic Structures Sculpted? (2009)
  • Author(s): Orikasa C
  • Journal Title: A Symposium at the 32nd Annual Meeting of Japan Neuroscience Society(Nagoya, Organizers : Kawata M, Sakuma Y) (招待講演)
• [Journal Article] Gonadal steroid action and brain sex differentiation in the rat. (2009)
  • Author(s): Sakuma Y
  • Journal Title: Journal of Neuroendocrinology 21(4) Pages: 410-414
  • Peer Reviewed
• [Journal Article] Cetrorelix, a gonadotropin-releasing hormoneantagonist, induces the expression of melatonin receptor 1a in the gonadotropin-releasinghormone neuronal cell line GT1-7. (2009)
  • Author(s): Ishii H, Sato S, Yin C, Sakuma Y, Kato M
  • Journal Title: Neuroendocrinology 90(3) Pages: 251-259
  • Peer Reviewed
• [Journal Article] Sex difference of somatostatin gene expression in the sexually dimorphic nucleus of the rat preoptic area. (2008)
  • Author(s): Orikasa C
  • Journal Title: Complementary Research Strategy for Morphology and Physiology. A symposium organized jointly by Anatomical and Physiological Societies of Japan at The85th Annual Meeting of the Physiological Society of Japan, Tokyo.(Organizers : Kawata M and Sakuma Y) (招待講演)
  • NAID: 130005449300
• [Presentation] Similar numbers of neurons area generated in the male and female rat preoptic area. (2011)
  • Author(s): Orikasa C.Konndo Y., Usui S., Sakuma Y
  • Organizer: 第88回日本生理学会大会第116回日本解剖学会総会・全国学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-29
• [Presentation] Sexual Dimorphism in the Preoptic Area of C57BL/6J and ddN Strains of Mice. (2010)
  • Author(s): Orikasa C., Sakuma Y
  • Organizer: The 7th International Congress of Neuroendocrinology-ICN 2010 Hormones and Behavior SBN
  • Place of Presentation: アメリカ合衆国
  • Year and Date: 2010-07-14
• [Presentation] Sexual Dimorphism in the Preoptic Area of C57BL/6J and ddN Strains of Mice. (2010)
  • Author(s): Orikasa C., Sakuma Y.
  • Organizer: The 7th International Congress of Neuroendocrinology ICN 2010
  • Place of Presentation: Rouen
• [Presentation] Sex steroids and the establishment of the sexually dimorphic nucleus of the rat preoptic area. (2009)
  • Author(s): Orikasa C., Kondo H., Usui S., Sakuma Y
  • Organizer: 39^<th> SfN the Annual Meeting Abs(Oct.17-21)
  • Place of Presentation: アメリカ合衆国
  • Year and Date: 2009-10-21
• [Presentation] Ontogeny of somatostatin neurons in the sexually dimorphic nucleus of the rat preoptic area (2009)
  • Author(s): Orikasa C., Kondo H., Usui S., Sakuma Y
  • Organizer: 36th International congress of physiological Science Abs/(July 27-Aug.1, 2009 in Kyoto)
  • Place of Presentation: 京都
  • Year and Date: 2009-07-28
• [Presentation] Postnatal neurogenesis does not contribute to estrogen-induced sex difference in the number of somatostatin neurons in the rat preoptic area (2009)
  • Author(s): Orikasa C., Kondo H., Usui S., Sakuma Y
  • Organizer: Hormones and Behavior SBN 2009 Annual meeting Abs.(June 21-26 in Mishgan)
  • Place of Presentation: アメリカ合衆国
  • Year and Date: 2009-06-26
• [Presentation] Sex steroids and the establishment of the sexuallydimorphic nucleus of the rat preoptic area. (2009)
  • Author(s): Orikasa C., Kondo Y., Usui S., Sakuma Y
  • Organizer: 39^<th> SfN the Annual Meeting Abs.
  • Place of Presentation: Chicago
• [Presentation] Ontogeny of somatostatin neurons in the sexually dimorphic nucleus of the rat preoptic area. (2009)
  • Author(s): Orikasa C., Kondo Y, Usui S., Sakuma Y.
  • Organizer: 36th International congress of physiological Science Abs.
  • Place of Presentation: Kyoto
• [Presentation] Postnatal neurogenesis does not contribute to estrogen-induced sex difference in the number of somatostatin neurons in the rat preoptic area. (2009)
  • Author(s): Orikasa C., Kondo Y., Usui S., Sakuma Y.
  • Organizer: Hormones and Behavior SBN Annual meeting Abs.
  • Place of Presentation: Michigan
• [Presentation] Sex steroid and the establishment of the sexually dimorphic nucleus of the preoptic area "How are neuroendocrine hypothalamic structure sculpted? (2009)
  • Author(s): 折笠千登世
  • Organizer: The 32th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Nagoya
• [Presentation] 脳の性差形成とステロイドホルモン (2009)
  • Author(s): 折笠千登世
  • Organizer: 第3回日本医科大学-早稲田大学シンポジウム(成体ホメオスタシスの神経科学的 神経内分泌的制御機構のupdate)
  • Place of Presentation: 東京
• [Presentation] Generation of the somatostatin neurons in the sexually dimorphic nucleus of the rat preoptic area (2008)
  • Author(s): Orikasa C., Kondo Y., Sakuma Y.
  • Organizer: Hormones and Behavior SBN Annual meeting Abs.
  • Place of Presentation: Groningen, the Netherlands
• [Presentation] Sex difference of somatostatin gene expression in the sexually dimorphic nucleus of the rat preoptic area (2008)
  • Author(s): 折笠千登世
  • Organizer: The 85^<th> Annnual Meeting of the Physiological Society of Japan.(Complementary research strategy for morphology ad physiology)
  • Place of Presentation: Tokyo, JAPAN
• [Presentation] Transient transcription of the somatostatin genein the sexually dimorphic nucleus of the rat pre-optic area. (2008)
  • Author(s): Orikasa, C. Sakuma, Y.
  • Organizer: The physiological Society of Japan
  • Place of Presentation: Tokyo
• [Presentation] Generation of the somatostatin neurons in thesexually dimorphic nucleus of the rat preoptic area (2008)
  • Author(s): Orikasa, C., Kondo, Y., Urakawa, S., Usui, S., Sakuma, Y.
  • Organizer: Society for Behavioral Neuro-endocrinology
  • Place of Presentation: Groningen, Netherlands