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Effects of ambient temperatures on rat neonatal hypoxic-ischemic encephalopathy assessed using simple behavioral tests.

Research Project

Project/Area Number 20590239
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionOsaka Electro-Communication University

Principal Investigator

HOSONO Takayoshi  Osaka Electro-Communication University, 医療福祉工学部, 教授 (60294104)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords低酸素虚血脳障害 / 環境温度 / 新生児 / 動物モデル / 行動学的評価 / 運動 / 学習 / 脳・神経 / 行動学 / 脳神経疾患 / ラット
Research Abstract

Human neonatal hypoxic-ischemic encephalopathy is one of the most important problems to be solved. Concerning this topic, we produced rat models of hypoxic-ischemic encephalopathy at various ambient temperatures on insult, and assessed motor and learning ability after reaching maturity using simple behavioral tests. The hypoxic-ischemic encephalopathy model rats produced at high ambient temperatures showed retardation of motor and learning abilities compared to those produced at normal ambient temperatures and controls. However, there was no anatomical difference in the brain morphology. These results suggest a discrepancy between the brain anatomy and behavior of rat models of hypoxic-ischemic encephalopathy at various ambient temperatures on insult.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (12 results)

All 2010 2009 2008

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (10 results)

  • [Journal Article] Effect of hypothermia on motor function of adult rats after neonatal hyperthermic hypoxic-ischemic brain insult.2010

    • Author(s)
      Hosono T, Kamo A, Hakotani S, Minato K, Akeno H, Taguchi Y, Miyano A, Iseki T
    • Journal Title

      European Journal of Applied Physiology 109(1)

      Pages: 35-9

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of hypothermia on motor function of adult rats after neonatal hyperthermic hypoxic-ischemic brain insult2010

    • Author(s)
      Hosono T, Kamo A, Hakotani S, Minato K, Akeno H, Taguchi Y, Miyano A, Iseki T.
    • Journal Title

      European Journal of Applied Physiology

      Volume: 109 Pages: 35-39

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Effects of hypothermia on spatial learning and memory in adult rats after neonatal hyperthermic hypoxic ischemic brain insult2010

    • Author(s)
      Hosono T, Hakotani S, Iseki T, Akeno H, Taguchi Y, Miyano A, Minato K
    • Organizer
      Neuroscience 2010
    • Place of Presentation
      San Diego Convention Center (San Diego, USA)
    • Year and Date
      2010-11-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effects of hypothermia on spatial learning and memory in adult rats after neonatal hyperthermic hypoxic ischemic brain insult.2010

    • Author(s)
      Hosono T, Hakotani S, Iseki T, Akeno H, Taguchi Y, Miyano A, Minato K
    • Organizer
      Neuroscience 2010
    • Place of Presentation
      San Diego (Convention Center), USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Effect of hypothermia on motor function of adult rats after neonatal hypoxic ischemic brain insult2009

    • Author(s)
      Hosono T, Kamo A, Hakotani S, Minato K, Akeno H, Taguchi Y, Miyano A
    • Organizer
      The 3rd International Symposium on Physiology and Pharmacology of Temperature Regulation 2009
    • Place of Presentation
      Matsue, Japan
    • Year and Date
      2009-07-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新生仔低酸素虚血脳症に対する環境温の効果の行動学的及び解剖組織学的評価2009

    • Author(s)
      湊健志, 細野剛良
    • Organizer
      第61回日本産科婦人科学会学術講演会
    • Place of Presentation
      京都市
    • Year and Date
      2009-04-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 幼若時にステロイド投与を行ったラットの成長中と成長後の運動・学習能力評価2009

    • Author(s)
      佐々木悠, 湊健志, 細野剛良
    • Organizer
      第61回日本産科婦人科学会学術講演会
    • Place of Presentation
      京都市
    • Year and Date
      2009-04-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新生仔低酸素虚血脳症に対する環境温の効果の行動学的及び解剖組織学的評価2009

    • Author(s)
      細野剛良
    • Organizer
      第61回日本産科婦人科学会総会・学術講演会
    • Place of Presentation
      京都市・国立京都国際会館
    • Year and Date
      2009-04-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] 幼若時にステロイド投与を行ったラットの成長中と成長後の運動・学習能力評価2009

    • Author(s)
      細野剛良
    • Organizer
      第61回日本産科婦人科学会総会・学術講演会
    • Place of Presentation
      京都市・国立京都国際会館
    • Year and Date
      2009-04-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effect of hypothermia on motor function of adult rats after neonatal hypoxic ischemic brain insult.2009

    • Author(s)
      Hosono T, Kamo A, Hakotani S, Minato K, Akeno H, Taguchi Y, Miyano A
    • Organizer
      The 3rd International Symposium on Physiology and Pharmacology of Temperature Regulation 2009 (PPTR2009)
    • Place of Presentation
      Matsue(Kunibiki Messe), Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] 新生仔低酸素虚血脳症に対する環境温の効果の行動学的及び解剖組織学的評価2009

    • Author(s)
      湊健志、細野剛良
    • Organizer
      第61回日本産科婦人科学会総会
    • Place of Presentation
      京都市(国立京都国際会館)
    • Related Report
      2010 Final Research Report
  • [Presentation] 新生仔低酸素虚血脳障害の効果の自発運動による評価2008

    • Author(s)
      湊健志、細野剛良
    • Organizer
      第47回日本生気象学会大会
    • Place of Presentation
      奈良市(奈良女子大学)
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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