| Project/Area Number |
20590241
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
|
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| Research Institution | Kinki University |
|---|
Principal Investigator |
UESHIMA Shigeru Kinki University, 農学部, 教授 (30193791)
|
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUO Osamu 近畿大学, 医学部, 教授 (40030879)
OKADA Kiyotaka 近畿大学, 医学部, 講師 (20185432)
YAMASHITA Rina 近畿大学, 農学部, 助手 (90510876)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 脂肪細胞 / 血管平滑筋細胞 / アディポサイトカイン / 動脈硬化 / アディポネクチン / PAI-1 / C3G / 遊走能 / アントシアニン / 線溶系因子 / t-PA / u-PA / 血管内皮細胞 / シアニジン |
|---|
| Research Abstract |
Obesity is one of the reasons that cause the lifestyle disease which includes atherosclerosis. In obesity, adipocyte accumulates a large amount of oil in its cytoplasm. And the obesity is the exacerbation factor for atherosclerosis. Also, the migration of smooth muscle cells (SMC) into intima is involved in progression of atherosclerosis. A definite food ingredient such as cyanidine-3-glucoside (C3G) inhibited the accumulation of oil in adipocyte and suppressed the enlargement of adipocyte. Furthermore, the defined food ingredients inhibited the migration of SMC in the presence of adipocyte, suggesting that they might be inhibit the progression of atherosclerosis.
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