The mechanism elucidation of the protective effect of prostanoids in ischemic myocardial protection

• Project/Area Number: 20590244
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Asahikawa Medical College
• Principal Investigator: YUHKI Koh-Ichi Asahikawa Medical College, 医学部, 講師 (80302420)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: プロスタノイド / プロスタグランジンE_2 / 心筋梗塞 / プレコンディショニング / 受容体欠損マウス / 虚血-再灌流障害

Research Abstract

Prostanoids are bioactive lipid mediators consisting of prostaglandins (PGs) and thromboxanes. On the other hand, Ischemic preconditioning (IPC) is a phenomenon that a brief ischemia of the heart induces a potent cardioprotective mechanism upon a succeeding ischemic insult. This research was analyzed about the roles of prostanoids in the ischemic heart disease using mice lacking PGE_2 receptor. We demonstrated that the PGE_2-EP_4 system exerts the cardio-protective effect in the late phase of IPC partly by augmenting the anti-apoptosis related signaling.

Research Products

• [Journal Article] Roles of prostanoids in the pathogenesis of cardiovascular diseases : Novel insights from knockout mouse studies. (2011)
  • Author(s): Yuhki K, Kojima F, Kashiwagi H, Kawabe J, Fujino T, Narumiya S, Ushikubi F
  • Journal Title: Pharmacol.Ther. 129 Pages: 195-205
  • Peer Reviewed
• [Journal Article] Roles of prostanoids in the pathogenesis of cardiovascular diseases : Novel insights from knockout mouse studies. (2011)
  • Author(s): Yuhki, K., et al.
  • Journal Title: Pharmaology & Therapeutics Volume: 129 Pages: 195-205
  • Peer Reviewed
• [Journal Article] プロスタノイド受容体ノックアウトマウス (2011)
  • Author(s): 結城幸一, 他
  • Journal Title: The Lipid Volume: 22 Pages: 120-127
• [Journal Article] Selective activation of the prostaglandin E_2 receptor subtype EP_2 or EP_4 leads to inhibition of platelet aggregation. (2010)
  • Author(s): Kuriyama S, Kashiwagi H, , Yuhki K, Kojima F, Yamada T, Fujino T, Hara A, Takayama K, Maruyama T, Yoshida A, Narumiya S, Ushikubi F
  • Journal Title: Thromb.Haemost. 104 Pages: 796-803
  • Peer Reviewed
• [Journal Article] Roles of prostanoids in the pathogenesis of cardiovascular diseases. (2010)
  • Author(s): Yuhki K, Kashiwagi H, Kojima F, Kawabe J, Ushikubi F
  • Journal Title: Int.Angiol. 29(2 Suppl) Pages: 19-27
• [Journal Article] Selective activation of the prostaglandin E_2 receptor subtype EP_2 or EP_4 leads to inhibition of platelet aggregation. (2010)
  • Author(s): Kuriyama, S., et al.
  • Journal Title: Thrombosis & Haemostasis Volume: 104 Pages: 796-803
  • Peer Reviewed
• [Journal Article] Prostaglandin I_2 promotes recruitment of endothelial progenitor cells and limits vascular remodeling. (2010)
  • Author(s): Kawabe, J., et al.
  • Journal Title: Arterioscler.Thromb.Vasc.Biol. 30 Pages: 464-470
  • Peer Reviewed
• [Journal Article] Roles of prostanoids in the pathogenesis of cardiovascular diseases. (2010)
  • Author(s): Yuhki, K., et al.
  • Journal Title: Int.Angiol. 29(2 Suppl 1) Pages: 19-27
• [Journal Article] プロスタノイドと循環器疾患 (2009)
  • Author(s): 結城幸一, 他
  • Journal Title: The Lipid 20 Pages: 277-283
• [Journal Article] プロスタノイドの循環器疾患における役割〜受容体欠損マウスを用いた解析〜 (2009)
  • Author(s): 結城幸一
  • Journal Title: 生化学 81 Pages: 84-94
  • NAID: 10024915785
• [Journal Article] プロスタノイド受容体欠損マウスの解析から明らかになったその病態生理における役割 (2008)
  • Author(s): 結城幸一
  • Journal Title: 最新医学 63 Pages: 1964-1971
• [Presentation] Prostaglandin E_2 protects the heart from ischemia-reperfusion injury via its receptor subtype EP_3. (2011)
  • Author(s): Yuhkki, K., et a1.
  • Organizer: KEYSTONE SYMPOSIA
  • Place of Presentation: 京都
  • Year and Date: 2011-06-09
• [Presentation] 脳梗塞病態形成におけるプロスタグランジンE_2受容体サブタイプEP_4の役割 (2010)
  • Author(s): 小島史章, 他
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪
  • Year and Date: 2010-03-17
• [Presentation] The Cardioprotective Effect of Prostaglandin E2/EP4 System is Important for the Late Phase (2009)
  • Author(s): Kanno T, Kawabe J, Yuhki K, Takehara N, Ushikubi F, Hasebe N
  • Organizer: Preconditioning American Heart Association Scientific Sessions 2009
  • Place of Presentation: アメリカ/オーランド
  • Year and Date: 2009-11-16
• [Presentation] The Cardioprotective Effect of Prostaglandin E_2/EP_4 System is Important for the Late Phase Preconditioning (2009)
  • Author(s): 菅野貴康, 他
  • Organizer: American Heart Association Scientific Sessions 2009
  • Place of Presentation: アメリカ/オーランド
  • Year and Date: 2009-11-16
• [Presentation] プロスタグランジンE2はEP4受容体を介して心臓における後期虚血プレコンディショニングを仲介している (2009)
  • Author(s): 菅野貴康、川辺淳一、結城幸一、竹原有史、長谷部直幸、牛首文隆
  • Organizer: 第60回日本薬理学会北部会
  • Place of Presentation: 富山
  • Year and Date: 2009-09-26
• [Presentation] プロスタグランジンE_2はEP_4受容体を介して心臓における後期虚血プレコンディショニングを仲介している (2009)
  • Author(s): 菅野貴康, 他
  • Organizer: 第60回日本薬理学会北部会
  • Place of Presentation: 富山
  • Year and Date: 2009-09-26
• [Presentation] プロスタグランジンE_2受容体サブタイプEP_4の脳梗塞病態形成における役割 (2009)
  • Author(s): 小島史章, 他
  • Organizer: 第60回日本薬理学会北部会
  • Place of Presentation: 富山
  • Year and Date: 2009-09-26
• [Presentation] 循環器疾患におけるプロスタノイドの役割 (2009)
  • Author(s): 結城幸一、成宮周、牛首文隆
  • Organizer: 第46回日本生化学会北海道支部会
  • Place of Presentation: 旭川
  • Year and Date: 2009-07-17
• [Presentation] 循環器疾患におけるプロスタノイドの役割 (2009)
  • Author(s): 結城幸一, 他
  • Organizer: 日本生化学会北海道支部第46回例会
  • Place of Presentation: 旭川
  • Year and Date: 2009-07-17
• [Presentation] プロスタグランジンE_2受容体サブタイプEP_2とEP_4の活性化は血小板凝集を抑制する (2009)
  • Author(s): 柏木仁、結城幸一, 他
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-03-16
• [Presentation] 炎症性頻脈における一酸化窒素の役割 (2009)
  • Author(s): 金井麻子、結城幸一, 他
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-03-16