| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
8-Nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP), formed nitric oxide (NO)-dependently, is a novel physiological second messenger. To study the physiological activity of 8-nitro-cGMP in the cardiovascular system, we studied its effects on vascular reactivity of mouse aortas. 8-Nitro-cGMP induced enhancement of contraction to phenylephrine and relaxation concentration-dependently in aortas from non-diabetic mice, but only relaxation in aortas from diabetic mice. It was suggested that 8-nitrocGMP- induced superoxide production via eNOS uncoupling may mediate the enhancement of the phenylephrine contraction. The vasodilator effect of 8-nitro-cGMP may contribute to amelioration of the vascular endothelial dysfunction in diabetic mice, representing a novel pharmacological approach toprevent the complications associated with diabetes.
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