| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
EAAC1 plays an important role in neuronal GSH synthesis. GTRAP3-18 is an EAAC1-binding protein to inhibit the function in neurons. However, it is still elusive that GTRAP3-18 negatively regulates neuronal GSH synthesis in vivo. In this study, we showed that intraventricular injection of GTRAP3-18 siRNA decreased GSHcontent in the hippocampus, while intraventricular injection of methyl β-cyclodextrin decreased GSH content with increased GTRAP3-18 expression in the hippocampus. These results suggest that GTRAP3-18 negatively regulates neuronal GSH synthesis in the hippocampus.
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