| Project/Area Number |
20590266
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Osaka University of Pharmaceutical Sciences |
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Principal Investigator |
MATSUMURA Yasuo Osaka University of Pharmaceutical Sciences, 薬学部, 教授 (40140230)
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| Co-Investigator(Kenkyū-buntansha) |
OHKITA Mamoru 大阪薬科大学, 薬学部, 講師 (60449824)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 心臓 / 虚血 / 再灌流 / 交感神経 / ノルアドレナリン / 性差 / 女性ホルモン / 虚血障害 / ノルエピネフリン / エストラジオール / 卵巣摘除 / エンドセリン / アンジオテンシン |
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| Research Abstract |
In cases of cardiac ischemia, which leads to the development of angina pectoris and cardiac infarction, noradrenaline (NA) release from sympathetic nerve endings is known to be enhanced and involved in the pathogenesis of the ischemic cardiac injury. In the present study, we elucidated the possible mechanisms of the above enhancement of NA overflow. We also clarified that there was a sex difference in the NA overflow from the post-ischemic heart, i. e., the amount of NA released from the heart of females was less than that of males, and the post-ischemic cardiac injury was attenuated in cases of females. Furthermore, it was found that estrogens are responsible for this sex difference.
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