Pathophysiological roles of 16kDa N terminal fragment of prolactin (PRL) in immune system

• Project/Area Number: 20590267
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Kansai Medical University
• Principal Investigator: HATTORI Naoki Kansai Medical University, 薬学部, 教授 (80288828)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 生理活性物質 / プロラクチン / 16Kフラグメント / 免疫細胞 / 免疫系 / マクロプロラクチン

Research Abstract

PRL, one of the anterior pituitary hormone, is secreted in large amounts during pregnancy and stimulates milk production. PRL is known to get several post-translational modifications such as cleavage to produce 16kDa N terminal fragment. In this preliminary study, it was shown that 1) 16kDa could be produced in the brain, 2) PRL receptors were expressed in hippocampal neurons and 3) 16kDa PRL had cytotoxic effects in immune cells and neurons.

Research Products

• [Journal Article] Macroprolactinaemia in patients with hyperprolactinaemia : composition of macroprolactin and stability during long-term follow-up (2010)
  • Author(s): Naoki Hattori, Takashi Ishihara, Yasuhiko Saiki, Akira Shimatsu
  • Journal Title: Clinical Endocrinology (Oxf) 73 Pages: 792-797
  • Peer Reviewed
• [Journal Article] Macroprolactinaemia in patients with hypeiprolactinaemia : composition of macroprolactin and stability during long-term follow-up (2010)
  • Author(s): Hattori N, et al.
  • Journal Title: Clinical Endocrinology Volume: 73 Pages: 792-797
  • Peer Reviewed
• [Journal Article] Macroprolactinaemia : Prevalence and Aetiologies in a Large Group of Hospital Workers (2009)
  • Author(s): Naoki Hattori, Takashi Ishihara, Yasuhiko Saiki
  • Journal Title: Clinical Endocrinology (Oxf) 71 Pages: 702-708
  • Peer Reviewed
• [Journal Article] Expression, regulation and biological actions of growth hormone (GH) and ghrelin in the immune system (2009)
  • Author(s): 服部尚樹
  • Journal Title: Growth Hormone & IGF Research 19 Pages: 187-197
  • Peer Reviewed
• [Journal Article] Macroprolactinaemia : Prevalence and Aetiologies in a Large Group of Hospital Workers (2009)
  • Author(s): Hattori N, et al.
  • Journal Title: Clinical Endocrinology 71 Pages: 702-708
  • Peer Reviewed
• [Journal Article] Expression, regulation and biological actions of growth hormone (GH) and ghrelin in the immune system (2009)
  • Author(s): Naoki Hattori
  • Journal Title: Growth Hormone & IGF Research (In press)
  • Peer Reviewed
• [Journal Article] Anti-prolactin (PRL) autoantibodies suppress PRL bioactivity in patients with macroprolactinaemia. (2008)
  • Author(s): Hattori N, Nakayama Y, Kitagawa K, Ishihara T, Saiki Y, Inagaki C
  • Journal Title: Clin Endocrinol (Oxf) 68 Pages: 72-76
  • Peer Reviewed
• [Journal Article] アルツハイマー病病の基礎と臨床-現状と課題(アミロイドβ蛋白の神経毒性機構) (2008)
  • Author(s): 服部尚樹、北川香織、中山靖久、稲垣千代子
  • Journal Title: 日本薬理学会雑誌 131 Pages: 326-332
• [Journal Article] 特集:プロラクチンの生理・病理の新展開「マクロプロラクチン血症」
  • Author(s): 服部尚樹、石原隆、島津章
  • Journal Title: HORMONE FRONTIER IN GYNECOLOGY (in press) Pages: 2011-2011
• [Journal Article] 特集「下垂体疾患の診断と治療-現状と課題-」高プロラクチン血症の内分泌診断
  • Author(s): 島津章,服部尚樹
  • Journal Title: ホルモンと臨床 (in press) Pages: 2011-2011
• [Presentation] Changes in serum prolactin (PRL) concentrations in subjects with macroprolactinemia having normal free PRL levels during 4 years follow-up. (2011)
  • Author(s): Hattori N, TaIshihara T, Shimatsu A
  • Organizer: The The 93^<rd> Annual meeting of American Endocrine Society
  • Place of Presentation: Boston MA, USA
  • Year and Date: 2011-06-06
• [Presentation] Possible involvement of 16kDa prolactin (PRL) in the pathophysiology of hippocampal neurons. (2011)
  • Author(s): Hattori N, Shimatsu A
  • Organizer: The The 93^<rd> Annual meeting of American Endocrine Society
  • Place of Presentation: Boston MA, USA
  • Year and Date: 2011-06-04
• [Presentation] マクロプロラクチン血症の長期経過の検討 (2011)
  • Author(s): 服部尚樹、石原隆、才木康彦、島津章
  • Organizer: 第84回日本内分泌学会
  • Place of Presentation: 神戸国際会議場(兵庫県)
  • Year and Date: 2011-04-23
• [Presentation] マクロプロラクチン血症:その頻度と病態 (2010)
  • Author(s): 服部尚樹、石原隆、才木康彦、島津章
  • Organizer: 第37回日本神経内分泌学会教育講演
  • Place of Presentation: 京都大学(京都府)
  • Year and Date: 2010-10-23
• [Presentation] マクロプロラクチン血症:その頻度と病態 (2010)
  • Author(s): 服部尚樹
  • Organizer: 第37回日本神経内分泌学会教育講演
  • Place of Presentation: 京都大学(京都)
  • Year and Date: 2010-10-23
• [Presentation] Long term follow up of macroprolactinaemia (2010)
  • Author(s): Hattori N, Ishihara T, Saiki Y, Shimatsu A
  • Organizer: The 92^<nd> Annual meeting of American Endocrine Society
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2010-06-21
• [Presentation] Long-term follow-up of macriprolactinaemia (2010)
  • Author(s): N Hattori, T Ishihara, Y Saiki, A Shimatsu
  • Organizer: The 92nd Annual Meeting of American Endocrine Society
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2010-06-21
• [Presentation] Macroprolactinemia : prevalence and aetiologies (2010)
  • Author(s): Hattori N, Saiki Y, Ishihara T
  • Organizer: 14th International Congress of Endocrinology
  • Place of Presentation: 京都国際会館(京都府)
  • Year and Date: 2010-03-28
• [Presentation] Characterization of macroprolactinaemia in patients with hyperprolactinaemia (2010)
  • Author(s): Hattori N, et al.
  • Organizer: International Congress of Endocrinology
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2010-03-27
• [Presentation] 薬物治療を要さない高プロラクチン血症の新たな原因「マクロプロラクチン血症」一般人における基礎的、臨床的検討 (2009)
  • Author(s): 服部尚樹
  • Organizer: 第82回日本薬理学会
  • Place of Presentation: 横浜
• [Presentation] アミロイドβタンパクの神経毒性機構 (2007)
  • Author(s): 服部尚樹
  • Organizer: 第80回日本薬理学会年会シンポジウム
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2007-03-16
• [Book] Advances in Medicine and Biology(Autoimmunity in the pituitary gland and the pituitary hormones.) (2011)
  • Author(s): Hattori N, Ishihara T, Shimatsu A
  • Publisher: NOVA Science Publishers, NY(in press)
• [Book] New Research on Autoantibodies (Claude T.Petrelli ed.)(Macroprolactinemia : A New Cause of Hyperprolactinemia Due to Anti-Prolactin (PRL) Autoantibodies.) (2008)
  • Author(s): Naoki Hattori
  • Publisher: NOVA Science Publishers, NY
• [Book] Macroprolactinemia : A New Cause of Hyperprolactinemia Due to Anti-Prolactin (PRL) Autoantibodies. New Research on Autoantibodies (Claude T. Petrelli ed. ) (2008)
  • Author(s): Naoki Hattori
  • Publisher: NOVA Science Publishers, NY
• [Remarks] ホームページ等