Pathophysiological roles of 16kDa N terminal fragment of prolactin (PRL) in immune system
| Project/Area Number |
20590267
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
HATTORI Naoki Kansai Medical University, 薬学部, 教授 (80288828)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 生理活性物質 / プロラクチン / 16Kフラグメント / 免疫細胞 / 免疫系 / マクロプロラクチン |
|---|
| Research Abstract |
PRL, one of the anterior pituitary hormone, is secreted in large amounts during pregnancy and stimulates milk production. PRL is known to get several post-translational modifications such as cleavage to produce 16kDa N terminal fragment. In this preliminary study, it was shown that 1) 16kDa could be produced in the brain, 2) PRL receptors were expressed in hippocampal neurons and 3) 16kDa PRL had cytotoxic effects in immune cells and neurons.
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Report
(4 results)
Research Products
(25 results)
