Search of new therapeutic agents for drug dependence and analysis of the inherited difference in patients with drug dependence.
| Project/Area Number |
20590269
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
KATSURA Masashi Kawasaki Medical School, 薬学部・薬学科, 准教授 (80204452)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 薬物依存 / アルコール / L型高電位開口性カルシウムチャネル / 熱ショック蛋白 / 神経細胞 / 鉄代謝 / physical dependence / psychological dependence / L-type high voltage-gated Ca^<2+>channel / stored operated Ca^<2+>channel / morphine / alcohol / Fe^<2+>content / L-type high voltage-gated Ca^<2+> channel / heme oxygenase-1 / heat shock protein / stress marker / calcium channel subunit / drug dependence / L-type calcium channels / neuronal calcium sensor-1 / cerebrocortical neurons / HEp2 cells / transfection / transformation |
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| Research Abstract |
We investigated the detailed and new common mechanisms underling the accentuation of L-type high voltage-gated calcium channels function in establishment of psychological and physical dependence. Phosphorylation of heat shock factor and following increase in heat shock proteins 70 (HSP70) were observed in sustained ethanol-treated neuronal cells. In addition, intracellular ferrous iron concentrations were also significant increased after long-term exposure of ethanol. These results suggest the possibility that increase in intracellular HSP70 expressions and ferrous iron concentrations are new target for mechanism of drug dependence.
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Report
(4 results)
Research Products
(25 results)
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[Presentation] Molecular mechanism of antihypertensive azelnidipine-induced augmention of insulin sensitivity : Evidence for antioxidative effect of insulin target 3T3-L1 cells.2010
Author(s)
Tatsumi F., Katsura M., Hashiramoto M., Tawaramoto K., Hamamoto S., Shimoda M., Kanda Y., Matsuda M., Kaku K.
Organizer
American Diabetes Association 70^<th> Scientific Sessions.
Place of Presentation
Orlando, FL, USA
Year and Date
2010-06-26
Related Report
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