| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
We studied the physiological function of Na^+/Ca^<2+> exchanger (NCX) in epithelial cells (renal tubular epithelium, vascular endothelium) and its pathological role, using genetically altered mice and NCX inhibitors. Suppression of NCX1 function (induced by heterozygous or isoform-specific inhibitor) mitigated the renal tubular injury after renal ischemic-reperfusion, whereas suppression of NCX2 function deteriorated the renal tubular injury. We also screened the protein associated with the intracellular domain of NCX1 (as a bait) by using yeast two-hybrid system, and then identified the new adapter protein (scaffold protein) bound to NCX1.
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