Regulation of dendritic cell functions by CD47-SIRPα system

• Project/Area Number: 20590274
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Gunma University
• Principal Investigator: KOBAYASHI Hisae Gunma University, 生体調節研究所, 技術専門職員 (80234839)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 樹状細胞 / SIRPα / 自然免疫 / T細胞 / CD47 / SHPS-1

Research Abstract

CD47 and SIRPα are transmembrane proteins and they constitute a cell-cell communication system by interacting their ectodomains. SIRPα predominatly expresses in dendritic cells and CD47-SIRPα system is important for regulation of immunity. In this research project, we have shown that CD47-SIRPα participates in regulation of induction of autoimmune diseases and homeostasis of dendritic cells. Furthermore, we found anti-SIRPα antibodies can regulate induction of autoimmune diseases.

Research Products

• [Journal Article] Regulation by SIRPα of dendritic cell homeostasis in lymphoid tissues. (2010)
  • Author(s): Saito Y., Iwamura H., Kaneko T., Ohnishi H., Murata Y., Okazawa H., Kanazawa Y., Sato-Hashimoto M., Kobayashi H., Oldenborg. P.-A., Naito M., Kaneko Y., Nojima Y., Matozaki T.
  • Journal Title: Blood Vol.116 Pages: 3517-3525
  • Peer Reviewed
• [Journal Article] Reeulation by SIRPα of dendritic cell homeostasis in lymphoid tissues (2010)
  • Author(s): Saito Y, 他
  • Journal Title: Blood Volume: 116 Pages: 3517-3525
  • Peer Reviewed
• [Journal Article] Expression of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 in pancreatic β-cells and its roles in promotion of insulin secretion and protection against diabetes. (2008)
  • Author(s): Kobayashi M., Ohnishi H., Okazawa H., Murata Y., Hayashi Y., Kobayashi H., Kitamura T., Matozaki T.
  • Journal Title: Endocrinology Vol.149 Pages: 5662-5669
  • Peer Reviewed
• [Journal Article] Essential roles of SHPS-1 in induction of contact hypersensitivity of skin. (2008)
  • Author(s): Motegi S., Okazawa H., Murata Y., Kanazawa Y., Saito Y., Kobayashi H., Ohnishi H., Oldenborg P.-A., Ishikawa O., Matozaki T.
  • Journal Title: Immunol.Lett. Vol.121 Pages: 52-60
  • Peer Reviewed
• [Journal Article] Expression of Src homology 2 domain-containing protein tyrosin phosphatase substrate-1 in pancreatic β-cells and its roles inpromotion of insulin secretion and protection against diabetes (2008)
  • Author(s): Kobayashi, M., 他
  • Journal Title: Endocrinology 149 Pages: 5662-5669
  • Peer Reviewed
• [Journal Article] Essential roles of SHPS-1 in induction of contact hypersensitivity of skin. (2008)
  • Author(s): Motegi, S., 他
  • Journal Title: Immunol. Lett. 121 Pages: 52-60
  • Peer Reviewed
• [Presentation] Expression of SHPS-1 in pancreatic β-cells and its role in promotion of insulin secretion and protection against diabetes. (2008)
  • Author(s): Kobayashi M., Ohnishi H., Murata Y., Hayashi Y., Kobayashi H., Kitamura T., Matozaki T.
  • Organizer: 第8回国際プロテインホスファターゼカンファレンス
  • Place of Presentation: 前橋テルサ(群馬)
• [Remarks]
  • URL: http://imcr.showa.gunma-u.ac.jp/lab/brc/index.html
• [Remarks]
  • URL: http://imcr.showa.gunma-u.ac.jp/lab/brc/index.html