Analysis of molecular mechanisms involving with the generation and the pathological condition of rhabdomyosarcoma induced by genetic recombination specifically in skeletal muscle
Project/Area Number |
20590276
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General medical chemistry
|
Research Institution | Mie University |
Principal Investigator |
SUZUKI Noboru Mie University, 生命科学研究支援センター, 准教授 (00202135)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 横紋筋肉腫 / ras / p53 / 自家癌モデル動物 / 遺伝子改変動物 / がん性悪液質 / カヘキシー / 癌モデル動物 / p53遺伝子 / 腫瘍幹細胞 |
Research Abstract |
An generated animal model for rhabdomyosarcomas(RMSs) expressing K-rasG12V gene specifically in skeletal muscle by Cre/LoxP system on p53-/- background developed pleomorphic RMSs and severe cachexia with incidence of 100%. Gene expression profiling of cachectic and non-cachectic cell lines derived primary tumors suggested various molecules involved with the RMS tumor development and disease state.
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Report
(4 results)
Research Products
(22 results)