| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Research Abstract |
The formation and accumulation of D-aspartate residue (D-Asp) in proteins caused by oxidative stress leads to denaturation of proteins, and is consequently responsible for aging-related misfolding diseases such as Alzheimer's disease. We sought to identify that an unknown protease selectively degrades the D-Asp-containing protein, namely D-aspartyl endopeptidase (DAEP), and finally purified it. DAEP therefore seems to physiologically serve as the quality control system against the noxious D-Asp-containing protein in the long life span of mammals.
|
