| Project/Area Number |
20590282
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Tottori University |
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Principal Investigator |
SATO Kenzo Tottori University, 医学部, 教授 (40113196)
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| Co-Investigator(Kenkyū-buntansha) |
HORI Naohiro 鳥取大学, 医学部, 准教授 (80263466)
NAKANISHI Tomoko 鳥取大学, 医学部, 助教 (10344863)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 遺伝子 / 再生医療 / 肝障害 / BMP受容体 / 損傷修復 / BMP遺伝子発現 / コンディショナルノックアウト / 細胞増殖マーカー / BMPプロモーター / 未分化肝細胞 |
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| Research Abstract |
We have found a transient expression of BMP-2/4 (bone morphogenetic protein) in early stage of CCl4-injured liver, and attempted to disclose the role of BMPs in repair process of injured liver in this study. As the results, we observed delay in recover of hepatic gene expression such as albumin, and decrease in expression of cell proliferation marker PCNA in liver injured by CCl4. These results suggested the important role of BMP signal in repair process.
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