Repair mechanism of liver injury in BMP receptor deficient mouse.
Project/Area Number |
20590282
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General medical chemistry
|
Research Institution | Tottori University |
Principal Investigator |
SATO Kenzo Tottori University, 医学部, 教授 (40113196)
|
Co-Investigator(Kenkyū-buntansha) |
HORI Naohiro 鳥取大学, 医学部, 准教授 (80263466)
NAKANISHI Tomoko 鳥取大学, 医学部, 助教 (10344863)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 遺伝子 / 再生医療 / 肝障害 / BMP受容体 / 損傷修復 / BMP遺伝子発現 / コンディショナルノックアウト / 細胞増殖マーカー / BMPプロモーター / 未分化肝細胞 |
Research Abstract |
We have found a transient expression of BMP-2/4 (bone morphogenetic protein) in early stage of CCl4-injured liver, and attempted to disclose the role of BMPs in repair process of injured liver in this study. As the results, we observed delay in recover of hepatic gene expression such as albumin, and decrease in expression of cell proliferation marker PCNA in liver injured by CCl4. These results suggested the important role of BMP signal in repair process.
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Report
(4 results)
Research Products
(24 results)
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[Presentation] ラット正常肝からの肝幹細胞株の樹立2008
Author(s)
平田みつひ, 吉野進, 天野久美子, 宮下肖美, 安永茉由, 佐藤建三
Organizer
第31回日本分子生物学会、第81回日本生化学会合同大会
Place of Presentation
神戸
Year and Date
2008-12-11
Related Report
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