| Project/Area Number |
20590284
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Kagawa University |
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Principal Investigator |
JIN Xinghua Kagawa University, 医学部, 外国人研究者 (50457339)
|
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| Research Collaborator |
UYAMA Toru 香川大学, 医学部, 助教 (30457337)
|
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | N-アシルエタノールアミン / アナンダミド / カンナビノイド / 酵素 / N-アシルトランスフェラーゼ / リン脂質 / エンドカンナビノイド / がん抑制遺伝子 / N-アシルトランスフェラーぜ |
|---|
| Research Abstract |
N-Acyltransferase is an enzyme involved in the biosynthesis of anandamide (an endogenous ligand of cannabinoid receptors) and related fatty acid amide compounds in animal tissues, and transfers a fatty acyl chain from a glycerophospholipid molecule to phosphatidylethanolamine (PE) to form N-acyl-PE. We found a novel enzyme catalyzing this reaction, cloned its cDNA from rat, mouse, and human, and characterized its recombinant proteins.
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