| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
The DjA2 knockout mice showed lethal respiratory failure after birth. This was caused by insufficient alveolar expansion and the type 2 pneumocytes from the knockout mice had abnormal acidity in the lumen of lysosomal acidic organelle. To elucidate the molecular mechanism of maintaining homeostasis in the acidic organelle, I analyzed the pnumocytes by a physiological approach using ratiometry, the DjA2 by a molecular interaction study using Biacore, and the lung tissue by a proteomics approach.
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