| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
The FOXO, a subfamily of forkhead type transcrption factors, plays
important roles in many physiological functions. FOXO1 is a member to be most important in energy metabolism. Moreover, it is also essential in angiogenesis during embryo. However, the function of FOXO1 in angiogenesis is controversial in detail. We studied angiogenesis in the retina of endothelium-specific deficient FOXO1 mice. The deficiency resulted in an impaired recruitment of pericytes to endothelial cells leading to death due to hemorrhage in the brain. The defect was mainly derived from a reduction of PDGF-B in the retina. The results suggest that FOXO1 play an important role in a stabilization of newly developed vessels.
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