functions of FOXO1 in the angiogenesis

• Project/Area Number: 20590292
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Kagawa Prefectural College of Health Sciences
• Principal Investigator: FURUYAMA Tatsuo Kagawa Prefectural College of Health Sciences, 教養部, 教授 (20238702)
• Co-Investigator(Kenkyū-buntansha): INAGAKI Shinob 大阪大学, 大学院・医学研究科, 教授 (90151571)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 血管 / 網膜 / 内皮細胞 / 転写因子 / 血管新生 / 腫瘍

Research Abstract

The FOXO, a subfamily of forkhead type transcrption factors, plays
important roles in many physiological functions. FOXO1 is a member to be most important in energy metabolism. Moreover, it is also essential in angiogenesis during embryo. However, the function of FOXO1 in angiogenesis is controversial in detail. We studied angiogenesis in the retina of endothelium-specific deficient FOXO1 mice. The deficiency resulted in an impaired recruitment of pericytes to endothelial cells leading to death due to hemorrhage in the brain. The defect was mainly derived from a reduction of PDGF-B in the retina. The results suggest that FOXO1 play an important role in a stabilization of newly developed vessels.

Research Products

• [Journal Article] FoxO1 is involved in the antineoplastic effect of calorie restriction. (2010)
  • Author(s): Yamaza H, Komatsu T, Wakita S, Kijogi C, Park S, Hayashi H, Chiba T, Mori R, Furuyama T, Mori N, Shimokawa I.
  • Journal Title: Aging Cell. 9(3) Pages: 372-382
  • NAID: 120006984942
• [Journal Article] FoxO1 is involved in the antineoplastic effect of calorie restriction. (2010)
  • Author(s): Yamaza H
  • Journal Title: Aging Cell Volume: 9 Pages: 372-382
  • Peer Reviewed
• [Journal Article] Foxo1 is essential for in vitro vascular formation from embryonic stem cells (2009)
  • Author(s): Park SH, Sakamoto H, Tsuji-Tamura K, Furuyama T, Ogawa M.
  • Journal Title: Biochem Biophys Res Commun. 390 Pages: 861-866
• [Journal Article] Different roles of Foxo1 and Foxo3 in the control of endothelial cell morphology. (2009)
  • Author(s): Matsukawa M, Sakamoto H, Kawasuji M, Furuyama T, Ogawa M.
  • Journal Title: Genes Cells 14 Pages: 1167-1181
• [Journal Article] Foxo1 is essential for in vitro vascular formation from embryonic stem cells (2009)
  • Author(s): Park SH
  • Journal Title: Biochem Biophys Res Commun 390 Pages: 861-866
  • Peer Reviewed
• [Journal Article] Different roles of Foxo1 and Foxo3 in the control of endothelial cell morphology (2009)
  • Author(s): Matsukawa M
  • Journal Title: Genes Cells 14 Pages: 1167-1181
  • Peer Reviewed
• [Presentation] Involvement of FOXO1 in angiogenesis in the retina. (2011)
  • Author(s): 植田慎之助
  • Organizer: 第116回日本解剖学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-29
• [Presentation] 網膜血管形成におけるFOXO1の役割 (2011)
  • Author(s): 植田慎之介、林美記子、石黒智子、宇仁一弘、田代ふみ、宮崎純一、古山達雄、稲垣忍
  • Organizer: 第116回日本解剖学会
  • Place of Presentation: 横浜