Functional analyses of transcription factors of ATF-2 gene family members by using knockout mouse
| Project/Area Number |
20590294
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
MAEKAWA Toshio The Institute of Physical and Chemical Research, 石井分子遺伝学研究室, 副主任研究員 (90201764)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ATF-2 / ATF-7 / ストレス / 転写制御 / エピジェネティクス / 肥満 / 行動異常 / セロトニン / ATF-2遺伝子ファミリー / ヘテロクロマチン / トリメチル化ヒストンH3K9 / ATF-7複合体 / DNA修復酵素 / CRE-BPa / HTR5B / p38阻害剤 / PPARγ2 / 肥満予防 / 脂肪分化 / p38 / 阻害剤 |
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| Research Abstract |
By the analyses of knockout mice of the ATF-2 gene family members, I have analyzed the physiological functions of ATF-2 gene family members. I have found that ATF-2 contribute to the developments of central nervous systems and macrophages. ATF-2 and CRE-BPa also contribute to the differentiations to the adipose tissue. On the other hand, ATF-7 represses the transcription of serotonin receptor 5b in the dorsal raphe nucleus in the brain stem. By the depletion of ATF-7, serotonin concentration was reduced and mouse showed abnormal behaviors.
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Report
(4 results)
Research Products
(24 results)
