| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
We have tried to differentiate immune-regulatory cells that play an important role in maintaining the immune-balance in the body from the embryonic stem (ES) cell. From our previous study, it is known that the rearranged configuration of the TCR plays an important role in a selective differentiation of the immune-regulatory cells. We have introduced such a TCR by the lentiviral vector into ES cells and let them differentiate into T cells. However, few immune-regulatory cells developed under such conditions. Our data indicate that the conversion of immune-regulatory cells into iPS cells or the nuclear transfer of such cells will be required to induce immune-regulatory cells.
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