Analysis of signal transduction in a novel mouse model.
| Project/Area Number |
20590299
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
WAKAO Hiroshi Hokkaido University, 大学院・医学研究科, 助教 (10280950)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 胚性幹(ES)細胞 / 免疫制御性T細胞 / TCR / 再生医学 / ES細胞 / 分化誘導 / レンチウイルスベクター / 免疫制御性細胞 / シグナル伝達 / サイトカイン / 胚性幹細胞 / T細胞分化 / 免疫制御能 / 能性幹細胞 |
|---|
| Research Abstract |
We have tried to differentiate immune-regulatory cells that play an important role in maintaining the immune-balance in the body from the embryonic stem (ES) cell. From our previous study, it is known that the rearranged configuration of the TCR plays an important role in a selective differentiation of the immune-regulatory cells. We have introduced such a TCR by the lentiviral vector into ES cells and let them differentiate into T cells. However, few immune-regulatory cells developed under such conditions. Our data indicate that the conversion of immune-regulatory cells into iPS cells or the nuclear transfer of such cells will be required to induce immune-regulatory cells.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Regulation of ghrelin signaling by a leptin-induced gene, negative regulatory element-binding protein, in the hypothalamic neurons.2010
Author(s)
Komori T, Doi A, Furuta H, Wakao H., Nakao N, Nakazato M, Nanjo K, Senba E, Morikawa Y.
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Journal Title
J Biol Chem. 285(48)
Pages: 37884-9
Related Report
Peer Reviewed
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[Journal Article] Regulation of ghrelin signaling by a leptin-induced gene, negative regulatory element-binding protein, in the hypothalamic neurons.2010
Author(s)
Komori, T., Doi, A., Furuta, H., Wakao, H., Nakao, N., Nakazato, M., Nanjo, K., Senba, E., Morikawa, Y.
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Journal Title
J.Biol.Chem.
Volume: 285
Pages: 37884-37894
Related Report
Peer Reviewed
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